Protein Alignment NKCC and B0303.11

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001299855.1
• Gene: B0303.11 / 176222
• WormBaseID: WBGene00015131
• Length: 927
• Species: Caenorhabditis elegans
• Alignment Length: 973
• Identity: 250/973 - (25%)
• Similarity: 440/973 - (45%)
• Gaps: 122/973 - (12%)

  Fly   142 VLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFI 206
            |.:.|:..:..|:|.||.|.:|.|:|...::|::..:.:|.::|..|...:.:....:.|.|..:
 Worm    24 VFLKCVQPMLAVVLLLRFSSIVDEAGFTTTIILVFFTFLVSLVTGWSACTVVSRKSSEVGFVKTM 88

  Fly   207 ISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLV 271
            ::.| ..||..|..:::.|...|:.|.......|::..:.....|:::|...:|:|:|.|:..|:
 Worm    89 LAYS-STEFAISFSIIYLFCLLVATSTFLTSAAEAVLHIFSTFSLELLDGATHDLRLVSSVLSLI 152

  Fly   272 LILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDY 336
            .:.:|.|........:.|:.....:||       |:       |:|.....:....|:.....:.
 Worm   153 TLALCMVRNRNARFVRTFIFALTCIAI-------AL-------QLSSVMFRYGEYQLRRVSDRNA 203

  Fly   337 RYAEGVNHDFFSVFAIFFPSVTGIQAGANICG-DLKDAGAAI----PKGTFWSLLISMSSYALFV 396
            ......|.:..::||..||        |.:|| .:.:.|:.:    |:|...::.:|       .
 Worm   204 MIPSPPNEEISTIFAQLFP--------AAMCGLTILNIGSKLQNTAPRGALIAIAVS-------A 253

  Fly   397 LFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAAT 461
            .|.|.||:.|.    .:....|..|:     :||:..:..|.||     :....|:......|..
 Worm   254 CFYGAAAMLDY----VEFFARTSTSN-----STGSAEYNEFLSY-----IYTTVPMAIVITLACV 304

  Fly   462 LSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAP 526
            || |::.|.....::|:||.......:::.:|.:|:...|.|..:|...:......||..:::..
 Worm   305 LS-AVSTLKYAAVILQSLGRSNQCRCILWLAKGFGERDIPIRCLLLLSTVQILVSAIGSYDILCI 368

  Fly   527 LISTFYLASYALINFCTFHAAFVKP-LGWRPTFKYYNAWLSLFGFAMC-VAIMF----LINYVAA 585
            ..:.|||.:|||.||..|......| :...||.      |||...|.| :|.::    |..::|:
 Worm   369 PTTVFYLFAYALFNFYVFLVKLSDPEIPSPPTL------LSLAISAACFIASLYTNRHLALFIAS 427

  Fly   586 IITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKT 650
            |........||::   |:.....|.......|.:.|..:|.||...|..:::|||:|:|||.|..
 Worm   428 IFAISYCSLLYII---RRERNEDGEECPKSMYSSVLEQMHELQQEPDSRRHFHPQILLLSGSPAA 489

  Fly   651 RPPLVDFGYLLTKNNSLMFVANIIPVRVGYK-----------------NRQHLV-----KDGQKY 693
            ||.||||.:.:|:..||:....||| ::..|                 :|.:|:     |....:
 Worm   490 RPGLVDFAHSITRGKSLLICGYIIP-KISNKVEQPMTWTEYLMQQSPCSRSYLLQLKIDKQINDW 553

  Fly   694 LDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNA 758
            |.||::.||...|......:|.|.|.::.|.|::.|||:::|||..|.:..||.:..|:.:|.||
 Worm   554 LRAREVNAFGAAICCTKQAEGANILLQTAGLGRLRPNILMLGYKTGWEKLSKESISEYYGMLSNA 618

  Fly   759 FSQRMGVALLR-LPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNL 822
            |.:::||.:.| ..:|.|.:....:...|.|.            ..:|....::|:..|   ::.
 Worm   619 FDKQVGVIIFRNEASGFDVTSSIRKNGAPIND------------DEDLAEYVDSATPKL---ADQ 668

  Fly   823 NLASMDSPN----SSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDA-MTI 882
            .....|.|.    ::|.....|...:::...|....:|:....:..|:....|  |.::.| |..
 Worm   669 GSQKKDVPRGKLLNTFRKMSMAVNKDLESGGRRSTSSSTRFQVIDKHSISEPD--QKIIMAQMFR 731

  Fly   883 FTRKQPKGTIDVFWLYDDGGLTILLPYIISMR-SHWQNSKLRVFAMCHGKDEE---QEEKSMASL 943
            |.::.|...||||||.:.||||:|.||:::.. |..:.:.:|||....|||.:   :|:|:||::
 Worm   732 FRKRIPNARIDVFWLREAGGLTMLAPYLLTQAGSFLEGAHIRVFTKTDGKDNKRINEEQKNMAAI 796

  Fly   944 LTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPFR-----RGARNEFGITDDELQSMSEKTNR 1003
            |.||.|..|:|.:|...|:.|...|..:.:..|:.::     .|...:....::::.::.|||..
 Worm   797 LRKFHIDSSDLHILPEFSKPPCKQTYDEFRAKIDKYKVETSSSGEPVDGSFDNNQIFNLREKTRS 861

  Fly  1004 QLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTL 1066
            .||..||:.:|||:|.|:|.:||..|.| |.:|:|:.|::|| |....|..|.||||..:..|
 Worm   862 FLRASELIREHSSDADLIVCTLPSARPE-IPSPIYLGWIDML-SRQTPPTCLVRGNQVSMSAL 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	250/973 (26%)
B0303.11	NP_001299855.1	AA_permease_2	2..916	CDD:459263	247/965 (26%)
		SLC12	490..919	CDD:460955	130/448 (29%)