Protein Alignment NKCC and kcc-3

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001338828.1
• Gene: kcc-3 / 174212
• WormBaseID: WBGene00019289
• Length: 1081
• Species: Caenorhabditis elegans
• Alignment Length: 1234
• Identity: 285/1234 - (23%)
• Similarity: 485/1234 - (39%)
• Gaps: 386/1234 - (31%)

  Fly    66 GFGNFLR--KSDAERKFS-LAQLTKESLPRL------------DNYRISMRNLKR--PSIGELQG 113
            ||.:..|  .|:|.|:|| :.|:..|.|..:            |......:..::  .|:|.|..
 Worm     3 GFQDLRRTVMSNARRRFSTVTQINTEGLQAMGKGGGRMETVGEDGIPADYKGNRKFTTSLGHLAL 67

  Fly   114 EAVDQSI----------TIPEPEPEATGGHIK--LGWIVGVLIPCLLNIWGVMLFLRLSWVVAES 166
            ...|:.|          |.|.|:..||..|:|  ||.::||.:|.:.:|.||.:|:||.|||..|
 Worm    68 YKEDEGIGTQASFISGYTTPGPKERATSEHVKANLGVMLGVYLPTIQHILGVTMFIRLFWVVGMS 132

  Fly   167 GILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSA 231
            |:..::.::.|..:..::|::||||::|||.|:.||.||||||:||.|||::||::|..||.|:|
 Worm   133 GVAWTMALLAICCLSTLLTSISLSAVATNGVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAA 197

  Fly   232 SMNTIGFCESLNVLL----------KNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKA 286
            ||..:|..|.:.:.|          ..:|.::..:..|::|:.|::.:|:..||..:|:::....
 Worm   198 SMYIVGGVEVILMYLWPEMAIGGADALHDTEMFGSLYNNLRLYGTVFLLIQALIVAMGVKFVQLL 262

  Fly   287 QNFLIVTIVLAIFNFLIGAAIGPQGNEEQISR--------------------------------- 318
            ....::.::||     |.|.|| .|.|:||:.
 Worm   263 APVSLMCVILA-----IAACIG-GGIEKQITMEGMKVCAIDNHLLQSSIVTHPIHKNQTSWFNET 321

  Fly   319 ----------------------------------------------GFVGFSWATLKENFGSDY- 336
                                                          .|.||:..||.:|...:|
 Worm   322 VDFCNLCDKSLYLESVFCANVNNDEASAEDDVFCTHYTSKKMTCQLAFPGFNMKTLNDNMWPEYM 386

  Fly   337 ------------RYAEGVNHD---FFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLL 386
                        ..||.|..:   ||.:.||:||:||||..|.|:.|||:|...:||.||..:.|
 Worm   387 EKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIFTGTNMSGDLRDPQRSIPVGTIAATL 451

  Fly   387 ISMSSYALFVLFAGG----AAVRDASGIPADLVNGTIVSSEL----PCMATGNCTWGLFNSYEMM 443
            .:.:.|.:..:..||    :.:||..|   ..:..|:|.:.|    |.:.|
 Worm   452 TTSAIYYILAILFGGSITRSVLRDKFG---RSIGNTMVVAALSWPHPAVVT-------------- 499

  Fly   444 QEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLT 508
                       .|.|.:|...||..|.|.|||:|::..|.:.|.|..|:: ..|:.||:.|.|||
 Worm   500 -----------VGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFAR-VTKNNEPFLGLVLT 552

  Fly   509 FFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMC 573
            ..|....:|:|.::.||.::..|:|..||.:|......:.:|...|||.|||::..|||.|.|:|
 Worm   553 VIIAECGILLGAVDKIAEVLDFFFLMCYAFVNLIAVLHSVLKSPNWRPRFKYFHWTLSLLGAALC 617

  Fly   574 VAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYH 638
            ..|||..:...|.|.......:|..|.::..:..||...:......|..::.::::...|.||:.
 Worm   618 FFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQYSLLKVEDKDPHPKNWR 682

  Fly   639 PQVLVLSGDPKTRP-------PLVDFGYLLTKNNSLMFVANIIPVRVGY---KNRQH-----LVK 688
            ||||:|.....::.       .:::.|..|.....|......:...|..   |||..     |||
 Worm   683 PQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLKGSVDSQKDKNRARDVKTTLVK 747

  Fly   689 DGQKYLDARKIKA-----FYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEV 748
            |    :.:.:::.     |||   ...:...|:.|.:|.|.|.:.||.:|:    :|
 Worm   748 D----MSSVRLRGFAKTMFYN---NHQINGTISGLYQSIGIGGLRPNTILL----NW-------- 793

  Fly   749 ESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAAS 813
                                  ||..:..||                             ...|.
 Worm   794 ----------------------PNEKNPDEL-----------------------------VLFAE 807

  Fly   814 ELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLD 878
            |::|..:|.|...:                                      |||.:|.|: ..:
 Worm   808 EIIHGAANDNCLIV--------------------------------------TKGITDFPE-YSE 833

  Fly   879 AMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAM---------------- 927
            .:|        |.||::|:..|||:.:|:.|::.....|:...||:||:
 Worm   834 RLT--------GFIDIWWIVQDGGILMLIAYLLRQHKVWKGCTLRIFAVSEQDSTKSEDMKAGLQ 890

  Fly   928 --------------------------------CHGKDEEQEE--KSMASLLT-----------KF 947
                                            ...|.:|:||  :|.:..|.           :.
 Worm   891 KYIYMLRIDAELFIVDLLDMEVSDEVVEKAAEVERKQKEREEMRRSKSGYLNDGFMEDNGKPRQV 955

  Fly   948 RIKYSELIMLKGVSEQPRADTVLKHKRLIEPFRRGARNEF---GITDDELQSMSE----KTNRQL 1005
            .:::|:  ..:..|.||.|.|.:........|.....::|   |..:::|:...:    |.|..:
 Worm   956 MMRHSD--SARSFSPQPGAHTSINLDETETSFTESLFDDFYRSGTPNEDLEGAMKLNIHKMNTSV 1018

  Fly  1006 RIHELVVKHSSNASLVVMSLPMPRKEAIS-APLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            |::.::.::|.::.|::::||.|.:..:: ...||::|::||.|:. .|....|:...|:|:.|
 Worm  1019 RLNRVIRENSPDSQLILLNLPSPPRNRLAFNNSYMTYLDVLTEDLP-RVLFIGGSGREVITIDS 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	275/1210 (23%)
kcc-3	NP_001338828.1	AA_permease_2	61..1081	CDD:459263	272/1174 (23%)