Protein Alignment NKCC and T04B8.5

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001022305.1
• Gene: T04B8.5 / 173453
• WormBaseID: WBGene00020207
• Length: 952
• Species: Caenorhabditis elegans
• Alignment Length: 1107
• Identity: 277/1107 - (25%)
• Similarity: 468/1107 - (42%)
• Gaps: 218/1107 - (19%)

  Fly     7 ISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFGNFL 71
            ::...|..|..|||....||         :|                |||.:|.:
 Worm    14 MTSYGGIVNEMYDGGGGDAE---------IP----------------GENGKSPK---------- 43

  Fly    72 RKSDAERKFSLAQLTKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGHIKL 136
                           |.::|.:|..  |....:..:.|:..|.:.....:...|     ||   |
 Worm    44 ---------------KGAVPLIDEE--SQSTPRGSTSGDGGGGSPSMEFSSSRP-----GG---L 83

  Fly   137 GWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGG 201
            ..|.||..|..|:::.::||||:.:||.:.|.|.:::.:.::..:.::|.|||.|||:||.|:||
 Worm    84 STISGVFAPVALSMFSILLFLRMGFVVGQLGFLMTILQLAMAYAIVMLTVLSLCAISSNGAVEGG 148

  Fly   202 GVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNG-INDI---R 262
            |||::||||||||||.::||:|..||..|.::...||.|:    |.||    :.|| ..|.   |
 Worm   149 GVYYMISRSLGPEFGGAIGVLFFVANVFSCALYISGFTEA----LMNN----IGNGQFPDSPAWR 205

  Fly   263 IVGSITV-LVLILICCVG--MEWETKAQNFLIVT------IVLAIFN----------------FL 302
            .|..:.| |||:::..:|  :..:|....|::::      ||..|||                .|
 Worm   206 FVYCVLVSLVLLVLSLLGSALFAKTALITFVLISVCYGTWIVSVIFNGRMEVLIPKVNTPAYRVL 270

  Fly   303 IGAAIGPQGNEEQ----ISRGFVGFSWATLKENFGSDYR--YAEGVNHDFFSVFAIFFPSVTGIQ 361
            :.|:...||..|.    ::..:.|:|:.||.||...:|.  |......||..:|||.|..|||:.
 Worm   271 VNASDPSQGTVEDFNQTLTANYTGWSFHTLGENMFPEYTMDYTTEKPTDFALMFAIIFSGVTGLM 335

  Fly   362 AGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPC 426
            ||||:.|:|.....:||:||..::.:::..|.:....
 Worm   336 AGANMSGELARPSVSIPRGTVQAVFMTLFVYVMTAFL---------------------------- 372

  Fly   427 MATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFF 491
            |||.:..:.|.|.|.:|.:.:.....|..|.|:.||.::::||:...|::..|..|:::..|:..
 Worm   373 MATTSSRYLLQNDYTVMMDTNFHRVFILIGIFSTTLFSSMSNLIGSSRVLNRLSHDKLFGCLLRP 437

  Fly   492 SKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRP 556
            :|.......|....|:|:.......|:|.:|.||.|.|.|:|.||..:|..|..........:||
 Worm   438 AKIEIGDRNPVVSVVITWMCVVLVFLVGAMNKIAKLTSIFFLLSYMGVNVATLALELTSAPNFRP 502

  Fly   557 TFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAAL 621
            ||||::......|......:|.:::...:.:...::.:|.:|:.|:.|..:.||.:||..|....
 Worm   503 TFKYFSWQTCALGVVATATMMLVVDASMSALGVVVLMSLIMVLHYQAPSVSSGSISQALIYHQVR 567

  Fly   622 MAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHL 686
            ..:..|....:|||.:.||:|:|...|.:...|:||...| |.:.|..|.:   ||.|..:...:
 Worm   568 KYLLLLDVRKEHVKYWRPQILLLVSRPASACSLLDFVNDL-KKSGLYLVGH---VRKGEMDSSQV 628

  Fly   687 VKDGQK-------YLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCR 744
            |...|:       .:|..|:|||..:....::..||..|.:.:|.|.|.||.|::|:
 Worm   629 VDPLQQVFPYWLSLIDYLKLKAFVELTMSNNIRHGIQQLMRLSGLGAMKPNTVVIGF-------- 685

  Fly   745 KEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPA- 808
                       :.....::.:...:|...|.||::.....:.....|........|....|.|.
 Worm   686 -----------HELAPSQVTLQESQLLKDLRFSKIDRAAVVEYFTAGDYMPKELDGNLERLTPVD 739

  Fly   809 -ANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDI 872
             .|...::||:..||.:|                        |.:  :..|:.|:.....|
 Worm   740 YVNVLKDVLHMTKNLCVA------------------------RHF--SKLDKEALARGWNG---- 774

  Fly   873 PQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTIL-LPYIISMRSHWQN-SKLRVFAMCHG-KDEE 934
            .:..:|...:..:| |:.| .:.|  |:..|.:| |..|:||.|.|:: :|||||...:. :|..
 Worm   775 QKRYIDVWPVDLQK-PQET-GLGW--DNSSLFLLQLSCILSMSSRWRSYTKLRVFICVNSLQDMH 835

  Fly   935 QEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPFRRGARNEFGITDDELQSMSE 999
            :.|:.:.::|...||        :|.|.....|.|:.|   .:|     .|.....:....|:..
 Worm   836 RRERQLKNMLQTLRI--------EGESSVVPWDHVVCH---YQP-----PNATASANTATPSVDL 884

  Fly  1000 KTNRQLRIHELVVKHSSNASLVVMSLPMPRKEA-ISAPLYMSWLEMLTSDMKCPVALARGNQTPV 1063
            ........:::|.::|.:|::.:::||:|...| |.|..|:..:..|| |...|..|..|..:.:
 Worm   885 PPAYVSAFNDMVKRYSEDAAITLLNLPVPPDNADIDADRYLEMVRNLT-DALPPTLLVHGVSSVI 948

  Fly  1064 LT 1065
            .|
 Worm   949 ST 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	265/1029 (26%)
		DUF502	507..>643	CDD:294696	37/135 (27%)
		SLC12	651..1068	CDD:281515	94/428 (22%)
T04B8.5	NP_001022305.1	2a30	85..943	CDD:273347	253/967 (26%)
		SLC12	593..943	CDD:281515	93/423 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910