DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NKCC and Slc12a8

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001357928.1	Gene:	Slc12a8 / 171286	MGIID:	2443672	Length:	705	Species:	Mus musculus

Alignment Length:	450	Identity:	128/450 - (28%)
Similarity:	230/450 - (51%)	Gaps:	70/450 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ELQGEAVDQSITI-PEP---------EPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVA 164
            ||..||..|.|.. |:|         ||      :..|...||...|::||:||:||||..|:|.
Mouse     8 ELFHEAAQQGILAQPQPWWKIQLFMWEP------VLFGTWDGVFTSCMINIFGVVLFLRTGWLVG 66

  Fly   165 ESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAV 229
            .:|:|..|::::...:|.:||.||...::.:|.:..||||.:||..||.:.|.:||:::.|...|
Mouse    67 NTGVLLGLLLVSFVVLVALITVLSGIGVAEHGGISSGGVYSMISSVLGGQMGGTVGLLYVFGQCV 131

  Fly   230 SASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCV---GMEWETKAQNFLI 291
            :.:|...||.||::.||          |:.||..|..|:|.||:.:..:   |::|..:.|..|:
Mouse   132 AGAMYITGFAESISDLL----------GLGDIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLL 186

  Fly   292 VTIVLAIFNFLIGA--AIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFF 354
            :.:.::..:|::|:  .:.|:       .||:|:|...|:.|...:|...|    .||:||.:||
Mouse   187 LLLAVSTLDFVVGSFTHLDPE-------HGFIGYSPELLQSNILPEYSPGE----SFFTVFGVFF 240

  Fly   355 PSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTI 419
            |:.||:.||.|:.|||:|...::|.|:..::.:|...|.:|....|....|:|
Mouse   241 PAATGVMAGFNMGGDLRDPADSVPLGSLAAVGVSWFLYIIFAFLLGAVCTREA------------ 293

  Fly   420 VSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQI 484
                            |.:.:.:.:::||.|.|...|.:.::|::.:..|...||::|.:..|::
Mouse   294 ----------------LRSDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQDKV 342

  Fly   485 YPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTF 544
            .|.|.|.:...|.:..|.....||..:|..|:|:|::|::||:::..::.:|.::::..|
Mouse   343 IPALAFLANGKGPNKTPVAAICLTSLVTMAFVLVGQVNVLAPVVTINFMLTYIMVDYSYF 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	127/449 (28%)
		DUF502	507..>643	CDD:294696	10/37 (27%)
		SLC12	651..1068	CDD:281515
Slc12a8	NP_001357928.1	2a30	34..>420	CDD:273347	119/423 (28%)
Slc12a8	NP_001357928.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..512
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810