Protein Alignment NKCC and Ncc69

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_061499156.1
• Gene: Ncc69 / 1281611
• VectorBaseID: AGAMI1_005952
• Length: 1141
• Species: Anopheles gambiae
• Alignment Length: 1150
• Identity: 516/1150 - (44%)
• Similarity: 720/1150 - (62%)
• Gaps: 122/1150 - (10%)

  Fly     3 DRFQISKVNGTANAGY---DGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRL-S 63
            :|||::.||....||:   :|.|            |.|.|  |:.|.|    |....||:||| |
Mosquito    30 NRFQVNLVNHDDPAGHGTGNGTA------------PEPVT--EDDLFP----EEMVKRRTSRLQS 76

  Fly    64 FRGFGNFLRKSDAER--------KF-------------------------SLAQLTKESLPRLDN 95
            .|......|..|.|:        :|                         |....|:|:|||:||
Mosquito    77 LRSSFRTDRDRDPEQPRQRKPSTRFNVEGGESDSNDDEEDNLIDENRYARSFRHFTREALPRMDN 141

  Fly    96 YR--ISMRNLKRPSIGELQGEAVDQSITIPEP-------EPEATGGHIKLGWIVGVLIPCLLNIW 151
            ||  :|.:..:||::.||.    |.|||..|.       ||....|.||.|||.|||:.||||||
Mosquito   142 YRNILSFQGNQRPTLDELH----DASITNKETMRRGTVHEPAELDGSIKFGWIKGVLMRCLLNIW 202

  Fly   152 GVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFG 216
            ||||||||||||.::||:|.:::|.::.||..||.||:|||||||.:||||.|::||||||||||
Mosquito   203 GVMLFLRLSWVVGQAGIVQGVVLICMTTVVTTITALSMSAISTNGVIKGGGTYYMISRSLGPEFG 267

  Fly   217 ASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGME 281
            .|:|::|:.||||:.:|..:|||||:..||.:..:.|||..:||:||:|.||:::|:.|..||||
Mosquito   268 GSIGLIFSLANAVACAMYVVGFCESMIDLLASFGVAIVDGAVNDVRIIGCITIVLLLCIVVVGME 332

  Fly   282 WETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDF 346
            ||.|||..|::.:::||.:|.:|:..||: :|..::|||||::...|.||..|.||.::|..|||
Mosquito   333 WEAKAQIVLLIILLVAIVDFCVGSLWGPK-SELDVARGFVGYNATVLMENMQSAYRVSKGTQHDF 396

  Fly   347 FSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIP 411
            ||||:||||:.|||.|||||.|||||..::|||||..::.|:.:||....:.||...:|||:|..
Mosquito   397 FSVFSIFFPAATGILAGANISGDLKDPSSSIPKGTILAIAITSASYIGMAVMAGATVLRDATGNV 461

  Fly   412 ADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLV 476
            .|:||||...|  .|..| :|.:||.||:::|:.:|::||||||||||||||:||.:|:|.|::.
Mosquito   462 TDVVNGTWDFS--ACEET-SCAYGLHNSFQVMELVSVFGPLIYAGCFAATLSSALASLVSAPKVF 523

  Fly   477 QALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINF 541
            |||..|::||.:.:|.|.:||:.||.|||:|||.|:...:|:|:||:||||||.|:||:|.|:||
Mosquito   524 QALCKDKLYPKISWFGKGFGKNNEPVRGYILTFVISVAVILVGDLNMIAPLISNFFLAAYCLVNF 588

  Fly   542 CTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEA 606
            .||||:..||:||||||||||.||||.|...|:|:||||::..|:|||..:.:|||:|.||||:.
Mosquito   589 STFHASLAKPVGWRPTFKYYNMWLSLLGAIFCIAVMFLISWPTALITFAAVLSLYLIVSYRKPDV 653

  Fly   607 NWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVA 671
            |||||||||.||.||::|.:|.||.:|||||.||:|||.|.|.:||.||:|.|||||..||:...
Mosquito   654 NWGSTTQAQTYKNALLSVQQLNNVEEHVKNYRPQILVLCGHPSSRPLLVNFAYLLTKKLSLLVCG 718

  Fly   672 NIIPVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGY 736
            ::....|..|.|.||.|...::....|:|.||::||....|.|..|:.:::|.||:.||::|:|:
Mosquito   719 HVTKTHVSQKYRNHLQKKAAEWFRRHKVKGFYSLIDDNDFETGSRAIMQASGIGKLRPNVLLMGF 783

  Fly   737 KPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSE----------VTLPANG-- 789
            |.||:||...|:|.||::::.|....:.||:||:..|.|:|::..|          .||.||.
Mosquito   784 KSDWDRCEPAELEQYFNVVHKALDMYLSVAILRVGKGFDYSQVLGEDTVKFISEYPRTLVANDST 848

  Fly   790 ---MGHMHTANAHGFTNELMPAANAASELLHIDSN----LNLASMDSPNSSFTM---PQPAPMPN 844
               :.|...::.||..:.|  :.|.:.:..: |.|    .||.:..:.:.|.|:   |.|..:..
Mosquito   849 NDLLSHNKVSSLHGSCDSL--SRNVSQDQTN-DVNEKNAKNLKASSTSDLSKTISVAPDPIDINA 910

  Fly   845 MQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPY 909
            ........:.....:|::.|...||:::|..:||.:|.||.|:..|.|||:|||||||||:||||
Mosquito   911 KLITETGQRSLKRGDPSLLYRGPGGAELPTEVLDELTQFTSKKKTGIIDVYWLYDDGGLTLLLPY 975

  Fly   910 IISMRSHWQNSKLRVFAMCHGKDE-EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHK 973
            |||.|.:|.:.||||||:.:.|.| |.|:::|||||.||||.||:|.:|..|:::|..:
Mosquito   976 IISTRRNWASCKLRVFALANRKTELEFEQRNMASLLAKFRIDYSDLQLLPDVTKKPNQE------ 1034

  Fly   974 RLIEPFRRGARNEFGITDD---------------ELQSMSEKTNRQLRIHELVVKHSSNASLVVM 1023
              :..|.:|...||...||               ||.::.:||||.|.:.|.:::|||.:.||||
Mosquito  1035 --MADFFKGLIKEFTAKDDAADASTAGTSTISKAELLAVQDKTNRHLNLREYLLQHSSKSDLVVM 1097

  Fly  1024 SLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            :||||||..:||||||:|||.|:.|:. |....|||||.|||.||
Mosquito  1098 TLPMPRKGVVSAPLYMAWLEALSRDLP-PFLFVRGNQTSVLTFYS 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	486/1029 (47%)
Ncc69	XP_061499156.1	None