DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NKCC and LOC100537771

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_003201788.4	Gene:	LOC100537771 / 100537771	-ID:	-	Length:	1091	Species:	Danio rerio

Alignment Length:	1124	Identity:	455/1124 - (40%)
Similarity:	661/1124 - (58%)	Gaps:	122/1124 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RFQISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFG 68
            |||:..| ..:.|....|...:.|...:..:|     ::....|..:|:|..:..|...|..|..
Zfish    31 RFQVDPV-ADSGAPKSSEEPKSRSRVVNFWNP-----SDGAADPGLNGDTVRSEASLHSSTGGLS 89

  Fly    69 NFLRKSDAE------RKFSLAQLTKESLPRLDNYRISM----RNLKRPSIGELQGEAVDQ----- 118
            :|   ||..      |.|  ...|.:::|.::.||.:.    ..|.|||:.||..| :|:
Zfish    90 HF---SDTHSSTYYLRTF--GHNTIDAVPNIEFYRQTEAPLGEKLLRPSLAELHDE-LDKEPFEE 148

  Fly   119 -----------SITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSL 172
                       .|..|:...::.||.:|.||:.||||.|:|||||||||:|:||:|.::||..|.
Zfish   149 GFPTAEELTAAEILTPKDLSDSKGGTVKFGWVKGVLIRCMLNIWGVMLFIRMSWIVGQAGIALSC 213

  Fly   173 IIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIG 237
            .||.::.||..||.||.|||:|||.|:|||.|::||||||||||.|:|::|||||||:.:|..:|
Zfish   214 GIILMAIVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVG 278

  Fly   238 FCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFL 302
            |.|::..||.:.|..:.|. ||||||||::||::|:.|...|||||.|||..|:|.::.||.|:.
Zfish   279 FAETVVELLDSIDALMTDE-INDIRIVGTLTVILLLGISVAGMEWEAKAQIVLLVILLAAIVNYF 342

  Fly   303 IGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANIC 367
            ||:.| |..::|  ||||.|:|.|.:.||.|.|:|..|    .||||||||||:.|||.|||||.
Zfish   343 IGSII-PMKSKE--SRGFFGYSAAIMMENMGPDFREEE----TFFSVFAIFFPAATGILAGANIS 400

  Fly   368 GDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVS-SELPC----- 426
            |||.|..:||||||..::||:...|....:..|...||||:|...|.|.|::.: ::..|
Zfish   401 GDLADPQSAIPKGTLLAILITGVVYIAVAISNGSCIVRDATGDDNDTVLGSLENCTDAACSLGYD 465

  Fly   427 ---MATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGL 488
               ...|.|.:||.|.:::|..:|.:||||.||.|:||||:||.:|:|.|::.|||..|:||||:
Zfish   466 FSICREGGCKYGLLNDFQVMSLVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDKIYPGI 530

  Fly   489 IFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLG 553
            ..|:|.|||:.||.|.|||||.|...|:||.|||:|||:||.|:|||||||||..|||:.....|
Zfish   531 HVFAKGYGKNKEPLRAYVLTFIIGLAFILIAELNIIAPIISNFFLASYALINFSVFHASLANSPG 595

  Fly   554 WRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYK 618
            |||:|||||.|:||.|..:|.|:||:||:.||::|.||:.|||:.|.|:||:.||||:|||..|.
Zfish   596 WRPSFKYYNKWVSLAGAVLCCAVMFVINWWAALMTNGIVLALYIYVSYKKPDVNWGSSTQALMYN 660

  Fly   619 AALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYK-- 681
            .||.....|..|.||:||:.||.|::.|.|.:||.|:...:..||:..||...:   ||.||:
Zfish   661 QALTHSLHLTGVEDHIKNFRPQCLLMCGYPNSRPALLYLTHTFTKDMGLMICGH---VRTGYRRP 722

  Fly   682 NRQHLVKDG---QKYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRC 743
            |.:.::.:.   |::|...:|||||:.:.......|...|.::.|.|::.||.:::|:|.:|...
Zfish   723 NYKEMLNEQARYQRWLLKMRIKAFYSPVFADDHRQGAQYLLQAAGLGRLKPNTLVLGFKNNWRDG 787

  Fly   744 RKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPA 808
            ...:||:|.:|:::||..:.||.||||..|||.|.:..|..                .:.|..||
Zfish   788 DMRDVETYINIIHDAFDLQYGVVLLRLKEGLDISHIQDEFL----------------SSQEKTPA 836

  Fly   809 ANAASELLHIDSNLNLASMDS----PNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGG 869
            ..  ..|:    ::|:...||    |:|..|..|.:|:..........|::::||
Zfish   837 MK--DPLV----SINIKDFDSDSSKPSSKSTSCQSSPLIFRDSKKPQLKLSAADE---------- 885

  Fly   870 SDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDE- 933
                 .||.|...|.:||.||||||:||:||||||:|:||:::.:..|::.|:|||  ..||..
Zfish   886 -----KLLSASQQFQKKQSKGTIDVWWLFDDGGLTLLIPYLLTNKKKWRDCKIRVF--IGGKINR 943

  Fly   934 -EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPFR-------------RGAR 984
             :.:.::||:||:||||.:|::.:|..::.:|:.......:.:.||:|             ..|.
Zfish   944 IDHDRRAMAALLSKFRIDFSDITVLGDINIKPKKHNKQVFQEMTEPYRLREDDMEQEAAEKLKAD 1008

  Fly   985 NEFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDM 1049
            ..:.|||:||:....|:|||:|::||:.:|||.|:|:|:::|:.||..:|:.||||||:.|:.|:
Zfish  1009 EPWRITDNELELYRSKSNRQIRLNELLQEHSSTANLIVITMPLARKGTVSSALYMSWLDTLSKDL 1073

  Fly  1050 KCPVALARGNQTPVLTLYS 1068
            . |:.|.|||...|||.||
Zfish  1074 P-PILLVRGNHQSVLTFYS 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	434/1035 (42%)
		DUF502	507..>643	CDD:294696	77/135 (57%)
		SLC12	651..1068	CDD:281515	143/440 (33%)
LOC100537771	XP_003201788.4	2a30	107..1091	CDD:273347	434/1035 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920