DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NKCC and slc12a3

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_002937217.2	Gene:	slc12a3 / 100494755	XenbaseID:	XB-GENE-866805	Length:	1030	Species:	Xenopus tropicalis

Alignment Length:	1116	Identity:	438/1116 - (39%)
Similarity:	626/1116 - (56%)	Gaps:	157/1116 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RFQISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFG 68
            ||.|..:..|.      ::..|:..|.::|:   .|.|.|:|           .::|.|..|.||
Frog    18 RFTIRSLISTE------DSIKAQYGQQESAY---DTFNPNNL-----------TQTSTLYMRTFG 62

  Fly    69 NFLRKSDAERKFSLAQLTKESLPRLDNY---RISMRNLK-RPSIGELQG----------EAVDQS 119
                           ..|.:::|..|:|   .||.:..| ||::.:|..          :..|..
Frog    63 ---------------YNTVDAIPNYDHYANTEISGQIKKVRPTLEDLHSILKQDSSHHLDPPDYD 112

  Fly   120 ITIPEPEPEA-------TGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITI 177
            .|:..|:.||       .|..::.|||.||:|.|:||||||:|:|||.|:.|::||..:.:||.:
Frog   113 NTVEPPDGEAENTEQKPAGEPVRFGWIKGVMIRCMLNIWGVILYLRLPWITAQAGIALTWLIIFM 177

  Fly   178 SAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESL 242
            |..|..||.||:|||||||:||.||.||:||||||||.|.|:|::|||||||:.:|:|:||.|::
Frog   178 SVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETV 242

  Fly   243 NVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAI 307
            ..||::.|..||| .||||||:|.|||:||:.|...|||||.|||....:.|:::..|:|:|..|
Frog   243 RDLLRDYDSTIVD-PINDIRIIGIITVIVLLGISLAGMEWEAKAQILFFIVIMISFANYLVGTVI 306

  Fly   308 GPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKD 372
              ...||:.::||..:......|||...:|..:|   .||.:|:|||||.|||.|||||.|||||
Frog   307 --PATEEKQAKGFFSYRADIFAENFVPKWRGQDG---SFFGMFSIFFPSATGILAGANISGDLKD 366

  Fly   373 AGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPC--MATG----- 430
            ...||||||..|:..:..||.:.....|...||||||    .:|.||....|.|  :|.|
Frog   367 PTVAIPKGTLMSIFWTTVSYLVISATIGSCVVRDASG----SLNDTITDGGLNCVGLACGYGWNF 427

  Fly   431 -------NCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGL 488
                   ||.:||.|.|:.|..:|.:.||:.||.|.||||:||..|:|.|::.|.|..|.:||.:
Frog   428 TDCATKQNCKYGLINQYQSMSMVSGFAPLVTAGIFGATLSSALACLVSAPKVFQCLCKDNLYPLI 492

  Fly   489 IFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLG 553
            .||.|.|||:.||.|||:|||.|.:.|:||||||.|||:||.|:|.|||||||..|||:.....|
Frog   493 GFFGKGYGKNNEPIRGYLLTFLIASAFILIGELNTIAPIISNFFLCSYALINFSCFHASITNSPG 557

  Fly   554 WRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYK 618
            |||:||||:.|.||||....|.||||:.:.:|:|..||:..|...|:|:||||||||:.||..|.
Frog   558 WRPSFKYYSKWASLFGAVASVVIMFLLAWESALIAIGIVIFLLGYVLYKKPEANWGSSVQAGSYN 622

  Fly   619 AALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNR 683
            .||.....|..|.:|:||:.||.|||:|.|..||.||||....||..|||...|:|   :|.:.:
Frog   623 MALSYCVGLNQVEEHIKNFRPQCLVLTGPPNFRPALVDFVGTFTKKQSLMICGNVI---IGPRKQ 684

  Fly   684 --QHLVKDGQ-KYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRK 745
              |.:..:|. |:|:.|||||||..:....|..|...|.::.|.|.|.||::::|:|.:|:....
Frog   685 KLQEISPEGHIKWLNKRKIKAFYTGLIADDLRSGTQMLIQAAGLGHMRPNVLVMGFKKNWSTSHP 749

  Fly   746 EEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAAN 810
            ...|:|..||::|...:.|:.|||:..|::.|                          .:|.|
Frog   750 RSTENYVGILHDALDFKCGLCLLRMKEGINIS--------------------------RVMQA-- 786

  Fly   811 AASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEP-AVTYHTKGGSDIPQ 874
                  ||            |..:...:...:.:...|..|....|:.:| |||...:
Frog   787 ------HI------------NPVYEQTEEPKLKDGGENGASCSAQSTLDPEAVTVEQQ------- 826

  Fly   875 NLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEEQEEKS 939
                |.|||..||.|.|||::||:||||||:|:||::|.:..||.:|:|||........::|.|:
Frog   827 ----ASTIFQIKQDKKTIDIYWLFDDGGLTLLIPYLLSRKKRWQKAKIRVFVGGQINRMDEECKA 887

  Fly   940 MASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPF--RRGARNE-----------FGITD 991
            |.|||:||||.:.|:.:|..::::||.:.:.:.:.||.|:  ..|.::|           :.|:|
Frog   888 MISLLSKFRIGFHEVHVLPDINQKPRPEHIKRFEDLIAPYMLNDGFKDELTVNEMRRDCPWKISD 952

  Fly   992 DELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALA 1056
            :|::....|:.||:|::|:::.:|.:|.|:|:::|:.||....:.|||:|||.|:.|::.||.|.
Frog   953 EEIKKNRAKSLRQIRLNEVLLDYSRDAGLIVITMPIARKGKCPSTLYMAWLETLSQDLRPPVLLT 1017

  Fly  1057 RGNQTPVLTLY 1067
            ||||..|||:|
Frog  1018 RGNQQNVLTMY 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	422/1035 (41%)
		DUF502	507..>643	CDD:294696	73/135 (54%)
		SLC12	651..1068	CDD:281515	140/434 (32%)
slc12a3	XP_002937217.2	2a30	64..1029	CDD:273347	422/1035 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm9379
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030