Protein Alignment NKCC and slc12a2

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_002931755.1
• Gene: slc12a2 / 100038244
• XenbaseID: XB-GENE-489652
• Length: 1161
• Species: Xenopus tropicalis
• Alignment Length: 1141
• Identity: 468/1141 - (41%)
• Similarity: 663/1141 - (58%)
• Gaps: 152/1141 - (13%)

  Fly     4 RFQISKVNGTA-------NAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGE----NR 57
            ||:::.|:..:       |||.||..........|.      ..:|..||   ||.||.    :.
 Frog    97 RFRVNFVDPASPGGSSPENAGVDGGGGGVSFQNGDT------VLSEGSLH---SGGTGHHYHYDT 152

  Fly    58 RSSRLSFRGFGNFLRKSDAERKFSLAQLTKESLPRLDNYRISM----RNLKRPSIGELQGEAVDQ 118
            .::....|.||:               .|.:::||:|:||.:.    ..|.|||:.||..| :|:
 Frog   153 HTNTYYLRTFGH---------------NTIDAVPRIDHYRHTAADLGEKLLRPSLAELHDE-LDK 201

  Fly   119 SITIPEP---------EPEATG----------GHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVA 164
                 ||         |...||          |.:|.|||.|||:.|:|||||||||:||||:|.
 Frog   202 -----EPFEDGFANGEEGTPTGDAATTVADSKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVG 261

  Fly   165 ESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAV 229
            ::||..::::|:::.||..||.||.|||:|||.|:|||.|::||||||||||.::|::|||||||
 Frog   262 QAGIGLTVVVISMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAV 326

  Fly   230 SASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTI 294
            :.:|..:||.|::..|||.|...:||: ||||||:|:|||::|:.|...|||||.|||..|:|.:
 Frog   327 AVAMYVVGFAETVVELLKENGALMVDD-INDIRIIGAITVVLLLGISVAGMEWEAKAQIVLLVIL 390

  Fly   295 VLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTG 359
            :|||.:|.||..|   .:|::..:||.|:......||||.|:|..|    .||||||||||:.||
 Frog   391 LLAIVDFFIGTVI---PSEDKKPKGFFGYKADIFSENFGPDFREGE----TFFSVFAIFFPAATG 448

  Fly   360 IQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSEL 424
            |.|||||.|||.|...|||:||..::||:...|....:..|...||||||.    ||.|:.::..
 Frog   449 ILAGANISGDLADPQHAIPRGTLLAILITTVVYMGVAVSVGSCVVRDASGD----VNSTLSAAMT 509

  Fly   425 PCMATG------------NCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQ 477
            .|....            .|.:||.||:::|..:|.:.|||.||.|:||||:||.:|:|.|::.|
 Frog   510 NCTTAACNLNYDFSSCGHECKYGLMNSFQVMSMVSGFAPLITAGIFSATLSSALASLVSAPKVFQ 574

  Fly   478 ALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFC 542
            ||..|.|||||..|:|.|||:.||.|||:|||.|..||:||.|||||||:||.|:|||||||||.
 Frog   575 ALCKDNIYPGLQMFAKGYGKNNEPLRGYLLTFIIALGFILIAELNLIAPIISNFFLASYALINFS 639

  Fly   543 TFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEAN 607
            .|||:..|..||||.|:|||.|:||.|..:|..:||:||:.||::|:.|:..||:.|.|:||:.|
 Frog   640 VFHASLAKSPGWRPAFRYYNMWVSLIGALLCCGVMFVINWWAALLTYVIVIGLYIYVTYKKPDVN 704

  Fly   608 WGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVAN 672
            |||:|||..|..||....||..|.|||||:.||.|||.|.|.:||.|:...:..|||..||...:
 Frog   705 WGSSTQALTYLNALQHTIRLAGVEDHVKNFRPQCLVLIGAPNSRPALLHLVHAFTKNVGLMICGH 769

  Fly   673 IIPVRVGYKNR--QHLVKDG---QKYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIV 732
               |.:|.:.:  :.|:.|.   |::|...|.||||:.:....|.||...|.::.|.|:|.||.:
 Frog   770 ---VHMGPRRQAMKELLTDQARYQRWLIKNKTKAFYSPVHAEDLRDGAQYLMQAAGLGRMRPNTL 831

  Fly   733 LVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTAN 797
            :||:|.:|::|...|||:|.::.::||..:.||.::||..|||.|.|..:..|.:
 Frog   832 VVGFKKNWSQCDMREVETYINLFHDAFDFQYGVVVIRLKEGLDISHLQGQEELLS---------- 886

  Fly   798 AHGFTNELMPAANAA------SELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTS 856
                :.|..|.....      |:....:|:...||..||              |.|........:
 Frog   887 ----SQEKSPGTKDVVVNVDYSKKAEAESSRPFASDSSP--------------MMRKDEEDDGKT 933

  Fly   857 SDEPAVTYHTKG-GSDI---PQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHW 917
            ..:|.:...:|| |..:   .|.||||...|.:||.|.||||:||:||||||:|:||:|:.:..|
 Frog   934 PTQPLLKKDSKGQGISLDTADQRLLDASLQFQKKQGKSTIDVWWLFDDGGLTLLIPYLITSKKKW 998

  Fly   918 QNSKLRVFAMCHGKDE--EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPFR 980
            ::.|:|||  ..||..  :.:.::||:||:||||.:|::::|..::.:|:.:.|...:.:|||||
 Frog   999 RDCKIRVF--IGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENVAAFEEMIEPFR 1061

  Fly   981 -------------RGARNEFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEA 1032
                         ......:.|||:||:....||:||:|::||:.:|||.|:.:|||||:.||.|
 Frog  1062 LHEDEKDQEVAEKMKEEEPWRITDNELELYKTKTHRQIRLNELLKEHSSTANAIVMSLPVARKSA 1126

  Fly  1033 ISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            :|:.|||:|:|.|:.|:. |:.|.|||...|||.||
 Frog  1127 VSSALYMAWIEALSKDLP-PILLVRGNHQSVLTFYS 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	447/1047 (43%)
		DUF502	507..>643	CDD:294696	78/135 (58%)
		SLC12	651..1068	CDD:281515	152/446 (34%)
slc12a2	XP_002931755.1	2a30	165..1161	CDD:273347	447/1047 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm9379
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010