Protein Alignment NKCC and slc12a3l

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_002934326.2
• Gene: slc12a3l / 100038063
• XenbaseID: XB-GENE-479312
• Length: 1115
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 418/1150 - (36%)
• Similarity: 617/1150 - (53%)
• Gaps: 176/1150 - (15%)

  Fly     3 DRFQISKVNGTANAGY----DGEARSAESDQTDAA-----HPLPPTSNENHLHPKASGETGENRR 58
            :..:.|..:..|::||    ||:......:....|     ..:...|:..|:.|.::    :|::
 Frog    55 ESLECSSGSDVASSGYTSTTDGQVLEIPEENVQEALQHLNQSIEAFSHGLHMFPCST----DNKK 115

  Fly    59 SSRLSFRGFGNFLRKSDAERKFS---------------------LAQLTKESLPRLDNY--RISM 100
            ..        :.|.|.:.|...|                     ||..|.::.||.:.|  .::.
 Frog   116 PE--------DCLDKIEVESSLSSGIALNPSALPYCQNLITKRQLAYNTLDATPRHEFYINSVAP 172

  Fly   101 RNLK--RPSIGELQGEAVDQSITIP-------------EPE-PEAT-----------GGHIKLGW 138
            ..||  |||:..|:...:|::.|:|             ||| ||..           .|.::.||
 Frog   173 GRLKRSRPSLDILRNAILDENETVPVSLDQDLETGNKNEPENPEMVNTKNNKKKKKESGPVRFGW 237

  Fly   139 IVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGV 203
            :.||:|.|:||||||:|:|||.|:.|::||..:.:||.:|.:|..||.||:|||||||:||.||.
 Frog   238 VKGVMIRCMLNIWGVILYLRLPWITAQAGIGLTWVIILMSVLVTSITGLSISAISTNGKVKSGGT 302

  Fly   204 YFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESL-NVLLKNNDLKIVDNGINDIRIVGSI 267
            ||:||||||||.|.|:|::|||||||:.:|:|:||.|:: ::|::.|  .::.:.:|||||:|.|
 Frog   303 YFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVRDLLIEYN--AVISDPVNDIRIIGVI 365

  Fly   268 TVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENF 332
            ||.||:.:...|||||.|||......|:::..::.:|..:.|  :||:.::||..:..:...||.
 Frog   366 TVTVLLGVSLAGMEWEAKAQIVFFFVIMVSFASYFVGTLMPP--SEEKQAKGFFSYQGSIFAENI 428

  Fly   333 GSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVL 397
            ..|:|   |....||::|:|||||.|||.|||||.|||||...||||||..|:..:..||.....
 Frog   429 VPDWR---GETSSFFAMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLLSIFWTTISYLAISA 490

  Fly   398 FAGGAAVRDASGIPADLVNGTIVSSE---------------LPCMATGNCTWGLFNSYEMMQEMS 447
            ..|...:||||||    :|.||..:|               ..|..|.:|.:||.|.|:.|..:|
 Frog   491 TIGSCVLRDASGI----LNDTIPINETTDCEGLSCQFGWNFTSCRETESCYYGLANHYQAMSMVS 551

  Fly   448 LWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFIT 512
            .:.|||.||.||||||:||..|:|.|::.|.|..|::||.:.||.|.|||:.||.|||:|:|.|.
 Frog   552 AFSPLITAGIFAATLSSALACLVSAPKVFQCLCKDKLYPFIGFFGKGYGKNNEPIRGYILSFAIA 616

  Fly   513 TGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIM 577
            ..|:||.|||.|||:||.|:|.|||||||..|||:.....||||:|:||:.|.||||..:.|.||
 Frog   617 IAFILIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWTSLFGAVVSVVIM 681

  Fly   578 FLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVL 642
            ||:.:.||||...||..|...|.|:|||.||||:.||..|..||.....|..|.:|||||.||.|
 Frog   682 FLLTWWAAIIAVAIIIILLGYVTYKKPEVNWGSSVQAGAYNMALTYSVNLSGVQEHVKNYRPQCL 746

  Fly   643 VLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQ-KYLDARKIKAFYNVI 706
            ||:|.|..||.||||...:|||.|||...|     |...:.:....:|| ::|:.||:.:||::|
 Frog   747 VLTGPPNFRPALVDFVSSVTKNTSLMICGN-----VAIDSDKITDSEGQLRWLNTRKVISFYSMI 806

  Fly   707 DGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLP 771
            ...:|..|...|.:.:|.|::.||.:::|||.:|.....:.:|.|..|:::||..:..|.:||:.
 Frog   807 YEKTLRAGAKNLMQVSGLGRLKPNTLVLGYKSNWQSDSVQNLEEYVGIIHDAFDCQFAVCILRIN 871

  Fly   772 NGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTM 836
            :|||.|:                                      .:...:|||..||.|.:|:.
 Frog   872 DGLDVSQ--------------------------------------KVQGQVNLAFQDSDNEAFSD 898

  Fly   837 PQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDG 901
            .:....|:                         |.:|:.|....|.|..:|.|.:|.|:||.|||
 Frog   899 KEDEKEPH-------------------------SPVPEILSQTNTEFQGRQGKKSIHVYWLSDDG 938

  Fly   902 GLTILLPYIISMRSHWQNSKLRVFAMCHGKDEEQEEKSMASLLTKFRIKYSELIMLKGVSEQPRA 966
            |||:|:||::..|..|...|::||..|..:..|:|:|.|.|||.|||:.:.|:::|....::|..
 Frog   939 GLTLLIPYLLKRRRRWSQCKVKVFIRCRTEKAEEEKKEMQSLLEKFRLGFQEVVVLTNADQKPHC 1003

  Fly   967 DTVLKHKRLIEPFRRGARN---------EFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVV 1022
            ..:...:.||.|:....|.         ..|||:.:|.....|:.|.:|::|::.::|.:|:|:.
 Frog  1004 RNMKVFEDLIAPYNVSTRQRTSEEAEIPSCGITEKDLVHYMAKSERYVRMNEILKENSQDAALIA 1068

  Fly  1023 MSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLY 1067
            :|||:..::...:.|||:||..|:.|:..|:...||||...||:|
 Frog  1069 ISLPIVSRDTCPSSLYMAWLASLSRDLNPPIVFIRGNQQDALTVY 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	400/1037 (39%)
		DUF502	507..>643	CDD:294696	73/135 (54%)
		SLC12	651..1068	CDD:281515	124/426 (29%)
slc12a3l	XP_002934326.2	2a30	155..1114	CDD:273347	400/1037 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030