DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NKCC and slc12a8

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_005167859.1	Gene:	slc12a8 / 100000006	ZFINID:	ZDB-GENE-030131-5654	Length:	708	Species:	Danio rerio

Alignment Length:	451	Identity:	130/451 - (28%)
Similarity:	222/451 - (49%)	Gaps:	65/451 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 PSIGELQGEAVDQSITIPEP---------EPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSW 161
            |.:.||..|....|....:|         ||      :..|...||...|::||:||:||||..|
Zfish     3 PQVQELFHEDAQGSQINAQPWWKVQLFVWEP------VLFGTWDGVFTTCMINIFGVVLFLRTGW 61

  Fly   162 VVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFA 226
            :|..:|:...::::::..:|.::|.:|...:|....|..||||.:||..||...|.:||:::.|.
Zfish    62 LVGNTGVFLGMLLVSLVVLVALVTVMSGVGVSECCSVGNGGVYSMISTVLGGRIGGTVGLLYVFG 126

  Fly   227 NAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLV-LILICCVGMEWETKAQNFL 290
            ..|:.:|...||.||:..:|......:| .||       |:.||: |:.|...|::|..:.|..|
Zfish   127 QCVAGAMYITGFAESIAQVLSLQSTWVV-RGI-------SVAVLLGLLGINLAGVKWIVRLQLVL 183

  Fly   291 IVTIVLAIFNFLIG--AAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIF 353
            :..:.::..:|:||  :.:.|:       .||||:|...|::|...||...|    .||:||.:|
Zfish   184 LGILAMSTLDFVIGTFSHLDPE-------HGFVGYSEKLLRKNTLPDYTAGE----TFFTVFGVF 237

  Fly   354 FPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGT 418
            ||:.||:.||.|:..||:.....||.||..::..|...|.:||...|....|:|
Zfish   238 FPAATGVMAGFNMSSDLQRPEHNIPVGTLAAVCTSWFLYLVFVFLLGAICTREA----------- 291

  Fly   419 IVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQ 483
                             |...:.:.:::||.|.|...|.:.::|::.:..|...||::|.:..::
Zfish   292 -----------------LRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQER 339

  Fly   484 IYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTF 544
            :.|.|.|..|..|.:..|.....||..||.||:.||::|::||:::..::.:|::|::|.|
Zfish   340 VIPVLAFLGKGRGPNKTPVAAICLTSLITMGFIFIGQVNVLAPIVTINFMLTYSVIDYCYF 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	130/451 (29%)
		DUF502	507..>643	CDD:294696	15/38 (39%)
		SLC12	651..1068	CDD:281515
slc12a8	XP_005167859.1	2a30	32..>400	CDD:273347	123/420 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910