Protein Alignment ksr and KSR1

DIOPT Version :10

• Sequence 1: NP_524236.2
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: XP_047292941.1
• Gene: KSR1 / 8844
• HGNCID: 6465
• Length: 950
• Species: Homo sapiens
• Alignment Length: 1003
• Identity: 323/1003 - (32%)
• Similarity: 461/1003 - (45%)
• Gaps: 223/1003 - (22%)

  Fly    36 IQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRL--NERIPANGLVPH 98
            :|.:||:|...|.||||:||:|:.|||||||.||:|||||..:....|:.:  .||.|.....|
Human    44 LQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYP- 107

  Fly    99 TTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQ 163
                ....||....:....:.. :.|..||:..|.:::.::::.|....:  ..:|..||..|:.
Human   108 ----RFSDWLYTFNVRPEVVQE-IPRDLTLDALLEMNEAKVKETLRRCGA--SGDECGRLQYALT 165

  Fly   164 NLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRG---------------SVGNIGLGNNSTA 213
            .|||.       |.......|...|.|.|.......|               ....:|...||..
Human   166 CLRKV-------TGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQ 223

  Fly   214 SPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNST------QGSQLTLTLTPSPPNSPFT 272
            .||             :::.|....|...:||.:|.|:.|      .|     .|||...:|..|
Human   224 GPR-------------SISVSALPASDSPTPSFSEGLSDTCIPLHASG-----RLTPRALHSFIT 270

  Fly   273 PSSGLSSSLNGTPQRSRGT--------PPPARKHQTLL--------SQSHVQVDGEQLARNRLPT 321
            |.:        |||..|.|        |||:||...||        |:||     |....||:
Human   271 PPT--------TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSH-----ESQLGNRI-- 320

  Fly   322 DPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTL 386
                |..||...|:        |.|           ||.:....:|.::.|||:........|.:
Human   321 ----DDVSSMRFDL--------SHG-----------SPQMVRRDIGLSVTHRFSTKSWLSQVCHV 362

  Fly   387 CQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRH-------IKEQGGYASLPHVHG 444
            |||.:.. .:||..|:..||..|.... |:|.:....:...|.       |......|:.||...
Human   363 CQKSMIF-GVKCKHCRLKCHNKCTKEA-PACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGT 425

  Fly   445 AAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPS 509
            ..|.  |.||.   .|....|.||||..||.|||||||||.|       ..:.:.|||...|.||
Human   426 LPKA--LTKKE---HPPAMNHLDSSSNPSSTTSSTPSSPAPF-------PTSSNPSSATTPPNPS 478

  Fly   510 LGKHQPSQFNFPNVTVTSSGGSGGVSLISNE-----PVPEQFPTAPATANGGLDSLVSSSNGH-- 567
            .|: :.|:||||           ....|.:.     |||                    |.||
Human   479 PGQ-RDSRFNFP-----------AAYFIHHRQQFIFPVP--------------------SAGHCW 511

  Fly   568 ----MSSLIGSQTSNAST---AATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTH 625
                ::..:.....|.|.   ||.|                 |.......:|.:..     .|..
Human   512 KCLLIAESLKENAFNISAFAHAAPL-----------------PEAADGTRLDDQPK-----ADVL 554

  Fly   626 KSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQ--WR--------QNSISLKEWDIPYGDLL 680
            ::::::.....:|.:..:.|.     |..:|..|.:  ||        |.|:.|:|||||:..:.
Human   555 EAHEAEAEEPEAGKSEAEDDE-----DEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVE 614

  Fly   681 LLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMN 745
            |.|.|||||:|.|||..|||:||::||..|....:| |:.|:.||.|::.|||||:|||||||||
Human   615 LGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDH-LKLFKKEVMNYRQTRHENVVLFMGACMN 678

  Fly   746 PPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIEN 810
            ||:|||:||.|||.||::::...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:|
Human   679 PPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDN 743

  Fly   811 GKVIITDFGLFSSTKLL---YCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSF 872
            |||:|||||||..:.::   ..:..|.:.|:||||||||::|.:.|.|...: |.|:..:|||:|
Human   744 GKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQ-LPFSKAADVYAF 807

  Fly   873 GTVWYELICGEFTFKDQPAESIIWQV--GRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFAR 935
            |||||||...::..|:|.||:.|||:  |.|||:.|.::..|::|.::|..||.::.:.||.|:.
Human   808 GTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSL 872

  Fly   936 LLSLLEHLPKKRLARSPSHPVNLSRSAE 963
            |:.:||.|||  |.|..|||.:..:||:
Human   873 LMDMLEKLPK--LNRRLSHPGHFWKSAD 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_524236.2	SAM_KSR1_N	33..86	CDD:466555	27/49 (55%)
		SAM_KSR1	92..166	CDD:463916	12/73 (16%)
		C1_KSR	370..418	CDD:410362	14/47 (30%)
		PK_KSR	678..946	CDD:270965	134/272 (49%)
KSR1	XP_047292941.1	SAM_KSR1_N	41..94	CDD:466555	27/49 (55%)
		SAM_KSR1	102..168	CDD:463916	12/73 (16%)
		C1_KSR1	346..392	CDD:410422	14/47 (30%)
		STKc_KSR1	612..890	CDD:271054	138/281 (49%)