DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and KSR1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001381512.1	Gene:	KSR1 / 8844	HGNCID:	6465	Length:	928	Species:	Homo sapiens

Alignment Length:	989	Identity:	317/989 - (32%)
Similarity:	452/989 - (45%)	Gaps:	217/989 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRL--NERIPANGLVPH 98
            :|.:||:|...|.||||:||:|:.|||||||.||:|||||..:....|:.:  .||.|.....|
Human    44 LQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYP- 107

  Fly    99 TTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQ 163
                ....||....:....:.. :.|..||:..|.:::.::::.|....:  ..:|..||..|:.
Human   108 ----RFSDWLYTFNVRPEVVQE-IPRDLTLDALLEMNEAKVKETLRRCGA--SGDECGRLQYALT 165

  Fly   164 NLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRG---------------SVGNIGLGNNSTA 213
            .|||.       |.......|...|.|.|.......|               ....:|...||..
Human   166 CLRKV-------TGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQ 223

  Fly   214 SPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNST------QGSQLTLTLTPSPPNSPFT 272
            .||             :::.|....|...:||.:|.|:.|      .|     .|||...:|..|
Human   224 GPR-------------SISVSALPASDSPTPSFSEGLSDTCIPLHASG-----RLTPRALHSFIT 270

  Fly   273 PSSGLSSSLNGTPQRSRGT--------PPPARKHQTLL--------SQSHVQVDGEQLARNRLPT 321
            |.:        |||..|.|        |||:||...||        |:||     |....||:
Human   271 PPT--------TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSH-----ESQLGNRI-- 320

  Fly   322 DPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTL 386
                |..||...|:        |.|           ||.:....:|.::.|||:........|.:
Human   321 ----DDVSSMRFDL--------SHG-----------SPQMVRRDIGLSVTHRFSTKSWLSQVCHV 362

  Fly   387 CQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRH-------IKEQGGYASLPHVHG 444
            |||.:.. .:||..|:..||..|.... |:|.:....:...|.       |......|:.||...
Human   363 CQKSMIF-GVKCKHCRLKCHNKCTKEA-PACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGT 425

  Fly   445 AAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPS 509
            ..|.  |.||.   .|....|.||||..||.|||||||||.|       ..:.:.|||...|.||
Human   426 LPKA--LTKKE---HPPAMNHLDSSSNPSSTTSSTPSSPAPF-------PTSSNPSSATTPPNPS 478

  Fly   510 LGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGS 574
            .|: :.|:||||......                                       |....|..
Human   479 PGQ-RDSRFNFPAAYFIH---------------------------------------HRQQFIFP 503

  Fly   575 QTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGS 639
            ..|..:.||.|                 |.......:|.:..     .|..::::::.....:|.
Human   504 DISAFAHAAPL-----------------PEAADGTRLDDQPK-----ADVLEAHEAEAEEPEAGK 546

  Fly   640 ASTDSDRTPVRVDSTEDGDSGQ--WR--------QNSISLKEWDIPYGDLLLLERIGQGRFGTVH 694
            :..:.|.     |..:|..|.:  ||        |.|:.|:|||||:..:.|.|.|||||:|.||
Human   547 SEAEDDE-----DEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVH 606

  Fly   695 RALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGN 759
            |..|||:||::||..|....:| |:.|:.||.|::.|||||:|||||||||||:|||:||.|||.
Human   607 RGRWHGEVAIRLLEMDGHNQDH-LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGR 670

  Fly   760 TLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSST 824
            ||::::...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:||||:|||||||..:
Human   671 TLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGIS 735

  Fly   825 KLL---YCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTF 886
            .::   ..:..|.:.|:||||||||::|.:.|.|...: |.|:..:|||:||||||||...::..
Human   736 GVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQ-LPFSKAADVYAFGTVWYELQARDWPL 799

  Fly   887 KDQPAESIIWQV--GRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLA 949
            |:|.||:.|||:  |.|||:.|.::..|::|.::|..||.::.:.||.|:.|:.:||.|||  |.
Human   800 KNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPK--LN 862

  Fly   950 RSPSHPVNLSRSAE 963
            |..|||.:..:||:
Human   863 RRLSHPGHFWKSAD 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	42/131 (32%)
		C1_1	368..419	CDD:278556	15/50 (30%)
		PK_KSR	678..946	CDD:270965	134/272 (49%)
		Pkinase_Tyr	679..940	CDD:285015	130/265 (49%)
KSR1	NP_001381512.1	C1	348..390	CDD:197519	13/43 (30%)
KSR1	NP_001381512.1	STKc_KSR1	590..868	CDD:271054	138/281 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	283	1.000	Domainoid score	I1649
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1655
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm41675
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880