DRSC/TRiP Functional Genomics Resources

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Protein Alignment ksr and MAP3K21

DIOPT Version :9

Sequence 1:NP_001287177.1 Gene:ksr / 40660 FlyBaseID:FBgn0015402 Length:966 Species:Drosophila melanogaster
Sequence 2:NP_115811.2 Gene:MAP3K21 / 84451 HGNCID:29798 Length:1036 Species:Homo sapiens


Alignment Length:420 Identity:107/420 - (25%)
Similarity:153/420 - (36%) Gaps:132/420 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   622 TDTHKS--------NDSDKTVSLSGSASTDS--------------DRTPVR---------VDSTE 655
            |||..|        :.|..:.|..||||..:              |...:|         .|:..
Human    10 TDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAV 74

  Fly   656 DGDSGQW-----RQNSISLKEWDIP---------------------YGDLLLLERIGQGRFGTVH 694
            .||.|.|     |:..|....:..|                     :..|.|.|.||.|.||.|:
Human    75 SGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVY 139

  Fly   695 RALWHG-DVAVKLLNEDYLQD-EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCK 757
            ||.|.| :||||...:|..|| ....|:.|.|...|...||.|::...|.|:..|:|.:|....:
Human   140 RATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFAR 204

  Fly   758 GNTLYTYIHQRREKFAMNRTLLIAQ--------------------------QIAQGMGYLHAR-- 794
            |.             |:||.|..|.                          |||:||.|||..  
Human   205 GG-------------ALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAF 256

  Fly   795 -EIIHKDLRTKNIF---------IENGKVIITDFGL----FSSTKLLYCDMGLGVPHNWLCYLAP 845
             .|:|:||::.||.         |.|..:.||||||    ..:||     |.....:.|   :||
Human   257 VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK-----MSTAGTYAW---MAP 313

  Fly   846 ELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQ 910
            |:|::..          |:..||::|:|.:.:||:.||..::.....::.:.|............
Human   314 EVIKSSL----------FSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST 368

  Fly   911 SGRDVKDLLMLCWTYEKEHRPQFARLLSLL 940
            .......|:..||..:...||.||.:|..|
Human   369 CPEPFAKLMKECWQQDPHIRPSFALILEQL 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ksrNP_001287177.1 KSR1-SAM 33..166 CDD:290277
C1_1 368..419 CDD:278556
PK_KSR 678..946 CDD:270965 87/307 (28%)
Pkinase_Tyr 679..940 CDD:285015 86/304 (28%)
MAP3K21NP_115811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 7/25 (28%)
SH3_MLK4 42..97 CDD:212991 9/54 (17%)
PKc_like 129..401 CDD:328722 84/301 (28%)
Leucine-zipper 1 425..446
Leucine-zipper 2 460..481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 923..954
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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