Protein Alignment ksr and BRAF

DIOPT Version :9

• Sequence 1: NP_001287177.1
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_001361187.1
• Gene: BRAF / 673
• HGNCID: 1097
• Length: 807
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 243/916 - (26%)
• Similarity: 374/916 - (40%)
• Gaps: 271/916 - (29%)

  Fly   128 LEQSLRLSDEEIRQLL------ADSPS---QREEEELRRLTRAMQNLRKCMESLESGTAASNNDP 183
            ::|.::|:.|.|..||      .:.||   :..||...:|....|..::.:|||.:||..|
Human    50 IKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFS---- 110

  Fly   184 EQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATE 248
                                     .:|:||..|     .....:|:|:...:..|..|:|:...
Human   111 -------------------------VSSSASMDT-----VTSSSSSSLSVLPSSLSVFQNPTDVA 145

  Fly   249 ELNSTQGSQLTLTLTPSPPNSP----FTPSSGLSSSLNGTPQRSRGTPPPARKHQTL---LSQS- 305
            ..|            |..|..|    |.|:.          ||   |..|||...|:   |.::
Human   146 RSN------------PKSPQKPIVRVFLPNK----------QR---TVVPARCGVTVRDSLKKAL 185

  Fly   306 -------------HVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPC 357
                         .:| |||     :.|.....|....|..::.|:...|            ||.
Human   186 MMRGLIPECCAVYRIQ-DGE-----KKPIGWDTDISWLTGEELHVEVLEN------------VPL 232

  Fly   358 SPGVGHVGMGHAIKHRFTKALGF-MATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSC---- 417
            :            .|.|.:...| :|.|..|:|.:| :..:|..|.|..|:.|:..||..|
Human   233 T------------THNFVRKTFFTLAFCDFCRKLLF-QGFRCQTCGYKFHQRCSTEVPLMCVNYD 284

  Fly   418 GLPREYVDEF--RH--IKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSS 478
            .|...:|.:|  .|  .:|:...|......|::..:|  ...::|    .|...|.|||.|....
Human   285 QLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAP--ASDSIG----PQILTSPSPSKSIPIP 343

  Fly   479 TPSSPA------LFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLI 537
            .|..||      .|.||:|       ||||                  |||.:.:.
Human   344 QPFRPADEDHRNQFGQRDR-------SSSA------------------PNVHINTI--------- 374

  Fly   538 SNEPVPEQFPTAPATANGGLDSLVSSS---------NGHMSSLIGSQTSNASTAATLTGSLVNST 593
              |||             .:|.|:...         |..|..|...|:...|       .|::|.
Human   375 --EPV-------------NIDDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPS-------PLLHSV 417

  Fly   594 TTTSTCSFFPRKL---STAGVDKRTPFTSEYTDTH----KSNDSDKTVSLSGSASTDSDR--TPV 649
            .:.....|.|..:   ||.|:....|.:...:.|:    :.:...:....|.|:|.|.:|  |..
Human   418 PSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLG 482

  Fly   650 RVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQD 714
            |.||::|               |:||.|.:.:.:|||.|.||||::..||||||||:||.. ...
Human   483 RRDSSDD---------------WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVT-APT 531

  Fly   715 EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLL 779
            ...|:.|::||...:.|||.|::|||| ....|.|||||..|:|::||.::|....||.|.:.:.
Human   532 PQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLID 595

  Fly   780 IAQQIAQGMGYLHAREIIHKDLRTKNIFI-ENGKVIITDFGLFSSTKLLYCDMGLGVPHNW---- 839
            ||:|.||||.||||:.|||:||::.|||: |:..|.|.||||.:            |...|
Human   596 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT------------VKSRWSGSH 648

  Fly   840 --------LCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKD-QPAESII 895
                    :.::|||:|| :|.:.|      ::..||||:||.|.|||:.|:..:.: ...:.||
Human   649 QFEQLSGSILWMAPEVIR-MQDKNP------YSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII 706

  Fly   896 WQVGRG-MKQSLANLQSG--RDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKK--RLARSPSHP 955
            :.|||| :...|:.::|.  :.:|.|:..|...:::.||.|.::|:.:|.|.:.  ::.||.|.|
Human   707 FMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEP 771

  Fly   956 VNLSRS 961
             :|:|:
Human   772 -SLNRA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	12/46 (26%)
		C1_1	368..419	CDD:278556	16/55 (29%)
		PK_KSR	678..946	CDD:270965	107/284 (38%)
		Pkinase_Tyr	679..940	CDD:285015	105/277 (38%)
BRAF	NP_001361187.1	RBD_BRAF	154..232	CDD:340654	21/108 (19%)
		C1_B-Raf	230..289	CDD:410421	19/71 (27%)
		STKc_Raf	503..755	CDD:270964	104/272 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810