Protein Alignment ksr and Limk1

DIOPT Version :10

• Sequence 1: NP_524236.2
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_113915.2
• Gene: Limk1 / 65172
• RGDID: 62055
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 686
• Identity: 149/686 - (21%)
• Similarity: 228/686 - (33%)
• Gaps: 208/686 - (30%)

  Fly   384 CTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKG 448
            |..|...:.|::.: .|.:..|.|........||....|::.:           .|..|.|..|.
  Rat    52 CCECSTSLSHQYYE-KDGQLFCKKDYWARYGESCHGCSEHITK-----------GLVMVAGELKY 104

  Fly   449 SP-----LVKKSTLGKPLHQQHGD-------SSSPSSSCTSSTPSSPALFQQRERELDQAGSSSS 501
            .|     |...:.:|      .||       |......|...|..:|.:.|
  Rat   105 HPECFICLACGNFIG------DGDTYTLVEHSKLYCGQCYYQTVVTPVIEQ-------------- 149

  Fly   502 ANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANG------GLDSL 560
              :|| .|.|.|.|......::..::.|..|    :|....|...|....|.:.      |:|..
  Rat   150 --ILP-DSPGSHLPHTVTLVSIPASAHGKRG----LSVSIDPPHGPPGCGTEHSHTVRVQGVDPG 207

  Fly   561 VSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTS---EYT 622
            ..|.:...|..||.:...           :|.|..        |.:....:|.....||   :.|
  Rat   208 CMSPDVKNSIHIGDRILE-----------INGTPI--------RNVPLDEIDLLIQETSRLLQLT 253

  Fly   623 DTHKSNDS-------------DKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDI 674
            ..|..:||             ....:.||.|.:.:.:.||....:.|...|.....|.:.:..|:
  Rat   254 LEHDPHDSLGHGPVSDPSPLASPVHTPSGQAGSSARQKPVLRSCSIDTSPGAGSLVSPASQRKDL 318

  Fly   675 -----------PY-----GDLLLLERIGQGRFG----TVHRALWHGDVAVKLLNEDYLQDEHMLE 719
                       |:     .||:..|.:|:|.||    ..||..  |:|.|  :.|....||....
  Rat   319 GRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRET--GEVMV--MKELIRFDEETQR 379

  Fly   720 TFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQI 784
            ||..||...:...|.|::.|:|.......|..:|...||.||...|.....::..::.:..|:.|
  Rat   380 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDI 444

  Fly   785 AQGMGYLHAREIIHKDLRTKNIFI-ENGKVIITDFGLFSSTKLLYCDMG---------------- 832
            |.||.|||:..|||:||.:.|..: ||..|::.||||   .:|:..:.|
  Rat   445 ASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGL---ARLMIDEKGQSEDLRSLKKPDRKKR 506

  Fly   833 ---LGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESI 894
               :|.|:    ::|||:|..          ..:....||:|||.|    :|           .|
  Rat   507 YTVVGNPY----WMAPEMING----------RSYDEKVDVFSFGIV----LC-----------EI 542

  Fly   895 IWQVGRGMKQSLANLQSGRDVKDLL----------------MLCWTYEKEHRPQFARLLSLLE-- 941
            |.:|..........:..|.:|:..|                :.|...:.|.||.|.:|...||
  Rat   543 IGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETL 607

  Fly   942 ------HLP----KKRLARS------------PSHP 955
                  |||    .::|.|.            |:||
  Rat   608 RMHLAGHLPLGPQLEQLERGFWETYRRGESSLPAHP 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_524236.2	SAM_KSR1_N	33..86	CDD:466555
		SAM_KSR1	92..166	CDD:463916
		C1_KSR	370..418	CDD:410362	7/33 (21%)
		PK_KSR	678..946	CDD:270965	83/319 (26%)
Limk1	NP_113915.2	LIM1_LIMK1	5..77	CDD:188846	6/25 (24%)
		LIM2_LIMK1	84..138	CDD:188848	12/70 (17%)
		PDZ_LIMK-like	160..258	CDD:467236	21/120 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..316		11/59 (19%)
		STKc_LIMK1	345..611	CDD:271123	77/301 (26%)