DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and Limk1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_113915.2	Gene:	Limk1 / 65172	RGDID:	62055	Length:	647	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	149/686 - (21%)
Similarity:	228/686 - (33%)	Gaps:	208/686 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 CTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKG 448
            |..|...:.|::.: .|.:..|.|........||....|::.:           .|..|.|..|.
  Rat    52 CCECSTSLSHQYYE-KDGQLFCKKDYWARYGESCHGCSEHITK-----------GLVMVAGELKY 104

  Fly   449 SP-----LVKKSTLGKPLHQQHGD-------SSSPSSSCTSSTPSSPALFQQRERELDQAGSSSS 501
            .|     |...:.:|      .||       |......|...|..:|.:.|
  Rat   105 HPECFICLACGNFIG------DGDTYTLVEHSKLYCGQCYYQTVVTPVIEQ-------------- 149

  Fly   502 ANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANG------GLDSL 560
              :|| .|.|.|.|......::..::.|..|    :|....|...|....|.:.      |:|..
  Rat   150 --ILP-DSPGSHLPHTVTLVSIPASAHGKRG----LSVSIDPPHGPPGCGTEHSHTVRVQGVDPG 207

  Fly   561 VSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTS---EYT 622
            ..|.:...|..||.:...           :|.|..        |.:....:|.....||   :.|
  Rat   208 CMSPDVKNSIHIGDRILE-----------INGTPI--------RNVPLDEIDLLIQETSRLLQLT 253

  Fly   623 DTHKSNDS-------------DKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDI 674
            ..|..:||             ....:.||.|.:.:.:.||....:.|...|.....|.:.:..|:
  Rat   254 LEHDPHDSLGHGPVSDPSPLASPVHTPSGQAGSSARQKPVLRSCSIDTSPGAGSLVSPASQRKDL 318

  Fly   675 -----------PY-----GDLLLLERIGQGRFG----TVHRALWHGDVAVKLLNEDYLQDEHMLE 719
                       |:     .||:..|.:|:|.||    ..||..  |:|.|  :.|....||....
  Rat   319 GRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRET--GEVMV--MKELIRFDEETQR 379

  Fly   720 TFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQI 784
            ||..||...:...|.|::.|:|.......|..:|...||.||...|.....::..::.:..|:.|
  Rat   380 TFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDI 444

  Fly   785 AQGMGYLHAREIIHKDLRTKNIFI-ENGKVIITDFGLFSSTKLLYCDMG---------------- 832
            |.||.|||:..|||:||.:.|..: ||..|::.||||   .:|:..:.|
  Rat   445 ASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGL---ARLMIDEKGQSEDLRSLKKPDRKKR 506

  Fly   833 ---LGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESI 894
               :|.|:    ::|||:|..          ..:....||:|||.|    :|           .|
  Rat   507 YTVVGNPY----WMAPEMING----------RSYDEKVDVFSFGIV----LC-----------EI 542

  Fly   895 IWQVGRGMKQSLANLQSGRDVKDLL----------------MLCWTYEKEHRPQFARLLSLLE-- 941
            |.:|..........:..|.:|:..|                :.|...:.|.||.|.:|...||
  Rat   543 IGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETL 607

  Fly   942 ------HLP----KKRLARS------------PSHP 955
                  |||    .::|.|.            |:||
  Rat   608 RMHLAGHLPLGPQLEQLERGFWETYRRGESSLPAHP 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556	8/34 (24%)
		PK_KSR	678..946	CDD:270965	83/319 (26%)
		Pkinase_Tyr	679..940	CDD:285015	77/300 (26%)
Limk1	NP_113915.2	LIM1_LIMK1	5..77	CDD:188846	6/25 (24%)
		LIM2_LIMK1	84..138	CDD:188848	12/70 (17%)
		PDZ	165..255	CDD:278991	19/112 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..316		11/59 (19%)
		TyrKc	342..604	CDD:197581	76/297 (26%)
		STKc_LIMK1	345..611	CDD:271123	77/301 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000