DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and ksr1b

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_021322127.1	Gene:	ksr1b / 556779	ZFINID:	ZDB-GENE-040724-45	Length:	982	Species:	Danio rerio

Alignment Length:	1035	Identity:	321/1035 - (31%)
Similarity:	472/1035 - (45%)	Gaps:	249/1035 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHT 99
            :||.:|::|.:.|:||||:||.|:.|||.|||.||.|||:|.|:.|..|..:.||.....|..:.
Zfish    46 LIQRLIEISISSLKGLRTKCAASNDLTQHEIRALEEKLVKYISKQLDWKRSVAERDRPLALDSYP 110

  Fly   100 TGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLS----DEEIRQLLADSPSQREEEELRRLTR 160
               .|..||..:.|....:.|...:| :|:..|::|    :|.:::|.:.|      ||..|:|.
Zfish   111 ---NLTDWLYTINLRPEIIEAVPVKL-SLDALLQMSSGQVEENMKRLGSSS------EECSRITA 165

  Fly   161 AMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVK 225
            |:    .|::|..........:...|..|    ||.....|...:.....:|:        :|:|
Zfish   166 AL----SCLKSATDTGVGLKKEGIPWIAD----PTEHDSTSADPLSCSMRATS--------YGLK 214

  Fly   226 GKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSPPN--------------SPFTPSSG 276
                        .:...||||...|.|      .::::..||:              .||:.|..
Zfish   215 ------------PTSWPSPSALPRLRS------CVSVSTLPPSDFPVVVYTRCDGLTDPFSSSPQ 261

  Fly   277 LSSSLNG---------TPQR------SRGTPPPARKHQTLL---------SQS------------ 305
            |:.:::|         .|:|      ||..|||:||...||         |||
Zfish   262 LNCNVSGLLSTPPVTPPPKRYGKLKPSRTPPPPSRKLLNLLPSITLTRSKSQSQLANRIDDLTPN 326

  Fly   306 ----------HVQVDG------EQLARNRLPTDPSPDSHSSTSSDIFVDP---NTNASSGGSSSN 351
                      :|||:|      :..:|:.|.:..||....:|.|.: .||   ..|.::.||
Zfish   327 KSGKKNKPLLNVQVNGGANGWEDSPSRSPLLSARSPCLPPNTPSHL-TDPAALRNNVTTHGS--- 387

  Fly   352 VLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPS 416
                  ||.|....:|..:.|||:.......||.:|:|.:.. .:||..||..||..|.... |.
Zfish   388 ------SPLVMRKDIGLDVTHRFSTKSWLSQTCQVCKKNMMF-GVKCKHCKVKCHNKCTKEA-PK 444

  Fly   417 C---------------GLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHG 466
            |               .:|....::.....|...|.:||        ..:.||.   .|....|.
Zfish   445 CRISFAQFPNKIRRTESVPSGINNQVERPAESQQYGTLP--------KAINKKD---HPPSLSHL 498

  Fly   467 DSSSPSSSCTSSTPSSPALFQQRE-------RELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVT 524
            ||||..||.|||||||||.|.|..       ......||:.|....|.....:|: .||.||:|:
Zfish   499 DSSSNPSSTTSSTPSSPAPFGQSNPLSATPPPNPSPKGSADSRFHFPAACYFQHR-QQFVFPDVS 562

  Fly   525 VTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVS-SSNGHMSSLIGSQTSNASTAATLTGS 588
             :||...||.:..|::                ||.:.| ||:||...
Zfish   563 -SSSHSEGGYTGESDQ----------------LDGVASQSSSGHRED------------------ 592

  Fly   589 LVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDS-DKTVSLSGSASTDSDRTPVRVD 652
                                  ||          |..:.:|: |:..|...|...:.|..|....
Zfish   593 ----------------------VD----------DDQQGDDAQDQEGSEEESEDDEVDDLPKYSG 625

  Fly   653 STEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHM 717
            ..:|..|.:..|.|:.|:|||:|:..|.|.|.||:||:|.|.|..|||:|||:||..|....||
Zfish   626 HFKDYISRKASQTSVDLREWDVPFEQLELGELIGKGRWGKVCRGRWHGEVAVRLLEIDGNNQEH- 689

  Fly   718 LETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQ 782
            |:.|:.||.|::.|||||:||||||||:||:|||:||.|||.|||:.:  |..|..:|:...|||
Zfish   690 LKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCKGRTLYSVV--RDSKLDINKIRQIAQ 752

  Fly   783 QIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDM---GLGVPHNWLCYLA 844
            :|.:|||||||:.|:||||::||:|.::.||:|||||||..:.::..|.   .|.:|..|:.|||
Zfish   753 EIVKGMGYLHAKGIVHKDLKSKNVFYDSNKVVITDFGLFGMSGVVQEDRRENELKLPRGWIYYLA 817

  Fly   845 PELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANL 909
            ||::|.:.|.. :.:||.|:..:|||:|||:||||....:...:||.:.:|:|:|.|  :.:.:|
Zfish   818 PEIVRKIGPGN-QEDCLPFSKAADVYAFGTIWYELQAKAWPIINQPTQVLIYQLGSG--EGIRSL 879

  Fly   910 QS------GRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNLSRSAE 963
            .:      |::|.::|..||.::.|.||.|.:|..|||.|||  |.|..|||.:..:|.:
Zfish   880 LTTKGTSLGKEVTEILSACWCFKAEDRPTFTQLSDLLEKLPK--LNRRLSHPGHFWKSED 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	47/134 (35%)
		C1_1	368..419	CDD:278556	16/65 (25%)
		PK_KSR	678..946	CDD:270965	129/276 (47%)
		Pkinase_Tyr	679..940	CDD:285015	124/269 (46%)
ksr1b	XP_021322127.1	KSR1-SAM	44..171	CDD:316101	48/138 (35%)
		C1	402..444	CDD:237996	14/43 (33%)
		STKc_KSR1	651..929	CDD:271054	133/285 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1542
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	O	PTHR23257
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980