DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and slpr

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	98/369 - (26%)
Similarity:	154/369 - (41%)	Gaps:	83/369 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 TDTHKSND--------SDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGD 678
            ||:..|.|        .||.........||.|...:.| |:..||          ::..:|.|.:
  Fly    75 TDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLNV-SSAIGD----------IQPHEIEYNE 128

  Fly   679 LLLLERIGQGRFGTVHRALWHG-DVAVKLLN---EDYLQDEHMLETFRSEVANFKNTRHENLVLF 739
            |.:.|.||.|.|..|||..:.| :||:|:.:   ||.:|  .|.:....|...|...:|||:...
  Fly   129 LDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQ--RMRDNVLQEAKLFWALKHENIAAL 191

  Fly   740 MGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTL--------LI--AQQIAQGMGYLH-- 792
            .|.|:|.. |.:|....:|.:|             ||.|        |:  |.|||:||.|||
  Fly   192 RGVCLNTK-LCLVMEYARGGSL-------------NRILAGKIPPDVLVNWAIQIARGMNYLHNE 242

  Fly   793 -AREIIHKDLRTKNIFI---------ENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPEL 847
             ...|||:||::.|:.|         :...:.||||||   .:.:|....:.....: .::.||:
  Fly   243 APMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGL---AREMYNTQRMSAAGTY-AWMPPEV 303

  Fly   848 IRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSG 912
            |          ....::.:|||:|:|.:.:|||.||..:|.....|:.:    |:..:...|...
  Fly   304 I----------SVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAY----GVAVNTLTLPIP 354

  Fly   913 RDVKD----LLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSP 952
            :...:    |:..||..:...||.|..:|..||.:...:...:|
  Fly   355 KTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	82/297 (28%)
		Pkinase_Tyr	679..940	CDD:285015	80/290 (28%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	6/28 (21%)
		TyrKc	129..386	CDD:197581	80/290 (28%)
		STKc_MLK	134..389	CDD:270963	80/288 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840