DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and MAP3K10

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens

Alignment Length:	400	Identity:	115/400 - (28%)
Similarity:	167/400 - (41%)	Gaps:	92/400 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 GVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPV-RVDSTEDGDSGQWRQN-------- 665
            |.....|..:...|...:.|.:.|:       ...||..| ..|....||.|.|...
Human    13 GTTPAGPVWTAVFDYEAAGDEELTL-------RRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGV 70

  Fly   666 ---------------SISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHG-DVAVKLLNEDYLQD 714
                           .:.|.: :||:.:|.|.|.||.|.||.|:||||.| :||||....|..:|
Human    71 FPSNYVAPGAPAAPAGLQLPQ-EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKD 134

  Fly   715 EHM-LETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTL 778
            ..: .|....|...|...:|.|::...|||:|||:|.:|....:|..|...:..||    :...:
Human   135 PAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR----VPPHV 195

  Fly   779 LI--AQQIAQGMGYLH---AREIIHKDLRTKNIF----IENGKVI-----ITDFGL----FSSTK 825
            |:  |.|:|:||.|||   ...|||:||::.||.    |||..:.     ||||||    ..:||
Human   196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTK 260

  Fly   826 LLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQP 890
                 |.....:.|   :|||:||...          |:..|||:|||.:.:||:.||..:::..
Human   261 -----MSAAGTYAW---MAPEVIRLSL----------FSKSSDVWSFGVLLWELLTGEVPYREID 307

  Fly   891 AESIIWQVGRG---------MKQSLANLQSG----RDVKDLLMLCWTYEKEHRPQFARLLSLLEH 942
            |.::.:.|...         ..:..|.|..|    ||.:     ||..:...||.|..:|..||.
Human   308 ALAVAYGVAMNKLTLPIPSTCPEPFARLLEGEPGPRDEE-----CWDPDPHGRPDFGSILKRLEV 367

  Fly   943 LPKKRLARSP 952
            :.:..|.:.|
Human   368 IEQSALFQMP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	97/300 (32%)
		Pkinase_Tyr	679..940	CDD:285015	95/293 (32%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	11/62 (18%)
		TyrKc	98..365	CDD:197581	95/293 (32%)
		PKc_like	103..368	CDD:304357	94/291 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910