DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and MAP3K9

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_011535090.1	Gene:	MAP3K9 / 4293	HGNCID:	6861	Length:	1166	Species:	Homo sapiens

Alignment Length:	397	Identity:	109/397 - (27%)
Similarity:	164/397 - (41%)	Gaps:	84/397 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 GVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWR----------- 663
            |.|...|:.:...:...:.:.:.|:.|.......|.      ||...||.|.|.
Human    49 GCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSK------DSQVSGDEGWWTGQLNQRVGIFP 107

  Fly   664 QNSIS---------------------LKEWDIPYGDLLLLERIGQGRFGTVHRALWHGD-VAVKL 706
            .|.::                     ::..:|.:.:|.|.|.||.|.||.|:||.|.|| ||||.
Human   108 SNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKA 172

  Fly   707 LNEDYLQD-EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRRE 770
            ...|..:| ...:|..|.|...|...:|.|::...|.|:..|.|.:|....:|..|...:..:|
Human   173 ARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR- 236

  Fly   771 KFAMNRTLLI--AQQIAQGMGYLHAR---EIIHKDLRTKNIFI----ENG----KVI-ITDFGL- 820
               :...:|:  |.|||:||.|||..   .|||:||::.||.|    |||    |:: ||||||
Human   237 ---IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA 298

  Fly   821 ---FSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICG 882
               ..:||     |.....:.|   :|||:|||..          |:..|||:|:|.:.:||:.|
Human   299 REWHRTTK-----MSAAGTYAW---MAPEVIRASM----------FSKGSDVWSYGVLLWELLTG 345

  Fly   883 EFTFKDQPAESIIWQVGRGMKQSLANLQS--GRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPK 945
            |..|:.....::.:  |..|.:....:.|  ......|:..||..:...||.|..:|..|..:.:
Human   346 EVPFRGIDGLAVAY--GVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408

  Fly   946 KRLARSP 952
            ......|
Human   409 SGFFEMP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	94/289 (33%)
		Pkinase_Tyr	679..940	CDD:285015	93/282 (33%)
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	10/62 (16%)
		STKc_MLK1	137..406	CDD:271047	95/292 (33%)
		TyrKc	144..403	CDD:197581	93/282 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910