Protein Alignment ksr and araf

DIOPT Version :9

• Sequence 1: NP_001287177.1
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_991306.1
• Gene: araf / 403063
• ZFINID: ZDB-GENE-050102-2
• Length: 608
• Species: Danio rerio
• Alignment Length: 621
• Identity: 174/621 - (28%)
• Similarity: 269/621 - (43%)
• Gaps: 157/621 - (25%)

  Fly   372 HRFTKALGF-MATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGG 435
            |.|.:...| :|.|..|.|.:|:.: :|..|.|..|:.|:..||..|
Zfish   103 HNFVRKTFFKLAYCDFCHKFLFNGF-RCQTCGYKFHQHCSSKVPTVC------------------ 148

  Fly   436 YASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSS 500
                            |...|:.|              .|.::|...||:.      :..|.:|.
Zfish   149 ----------------VDMDTMTK--------------RCVNNTEDCPAIL------IYPATNSI 177

  Fly   501 SANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPAT------ANGGLDS 559
            |.:.||                :|..|.||              :.|::|:.      ...| .|
Zfish   178 SQSDLP----------------LTSDSPGG--------------ELPSSPSNFCLFIRGEDG-QS 211

  Fly   560 L-----VSSSNGHMSSLIG-------SQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVD 612
            |     .|:.|.||.|.:.       .:....||.|:.||...:...:||     |..|.:.|
Zfish   212 LQRHRSTSTPNVHMVSTLEPGAAGLLEEPFKISTVASYTGYESSPKPSTS-----PPHLGSPG-- 269

  Fly   613 KRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYG 677
            ::.|.:.......|.:.||             |:..|.        .|.:|.:|.   .|::...
Zfish   270 RKPPKSPSEPKERKQSSSD-------------DKKKVH--------RGGYRDSSY---YWEVHPR 310

  Fly   678 DLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGA 742
            ::.:|:|||.|.||||.:..||||||:|:|.......| .|:.|::|:...:.|||.|::||||
Zfish   311 EVSMLKRIGAGSFGTVFKGKWHGDVAIKILKVTEPTPE-QLQAFKNEMQVLRKTRHVNILLFMG- 373

  Fly   743 CMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIF 807
            .|..|..||:|..|:|::||.::|....||...|.:.:|:|.||||.||||:.|||:||::.|||
Zfish   374 FMTRPNFAIITQWCEGSSLYRHLHVTETKFDTMRRIDVARQTAQGMDYLHAKNIIHRDLKSNNIF 438

  Fly   808 IENG-KVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYS 871
            :..| .|.|.||||.:..........:..|...:.::|||:|| :|...|      :|..||||.
Zfish   439 LHEGWTVKIGDFGLATVKSRWSGSQQVEQPSGSILWMAPEVIR-MQDTNP------YTFQSDVYG 496

  Fly   872 FGTVWYELICGEFTFKD-QPAESIIWQVGRG-MKQSLANLQSG--RDVKDLLMLCWTYEKEHRPQ 932
            :|.|.|||:.|...:.: ...:.||:.|||| :...|:.|.|.  :.:|.|::.|..::::.||.
Zfish   497 YGVVLYELMSGTLPYSNINNRDQIIFMVGRGYLSPDLSKLYSNCPKSMKRLIIDCLKFKRDERPL 561

  Fly   933 FARLLSLLEH----LPKKRLARSPSHPVNLSRSAES 964
            |.::|..:|.    |||  :.||.|.| :|.|:..:
Zfish   562 FPQILVSIEQVQELLPK--IERSASEP-SLHRAVHA 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556	16/47 (34%)
		PK_KSR	678..946	CDD:270965	105/276 (38%)
		Pkinase_Tyr	679..940	CDD:285015	102/265 (38%)
araf	NP_991306.1	Raf_RBD	24..95	CDD:176411
		C1	103..148	CDD:237996	15/45 (33%)
		STKc_A-Raf	311..575	CDD:271052	103/272 (38%)
		Pkinase	315..566	CDD:278497	101/259 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810