DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and Tak1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	65/280 - (23%)
Similarity:	132/280 - (47%)	Gaps:	29/280 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   674 IPYGDLLLLERIGQGRFGTVHRALWHGD-VAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLV 737
            :.:.::.|.|::|.|.:|.|.:|:|... ||||   |.:...|.  :....||......:|.|::
  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVK---EFFASAEQ--KDIEKEVKQLSRVKHPNII 73

  Fly   738 LFMGACMNPPYLAIVTSLCKGNTLYTYIHQR-REKFAMNRTLLIAQQIAQGMGYLHA---REIIH 798
            ...|.........::....:|.:|:.::|.: :..:::...:..|:|.|:|:.||||   :.:||
  Fly    74 ALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIH 138

  Fly   799 KDLRTKNIFIEN-GKVI-ITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECL 861
            :|::..|:.:.| |:.: |.|||..:....:..:     ......::|||:.          |..
  Fly   139 RDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTN-----NRGSAAWMAPEVF----------EGS 188

  Fly   862 EFTPYSDVYSFGTVWYELICGEFTFKD-QPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTY 925
            ::|...|::|:..|.:|::..:..||. ..|.:|.|::.:|.:..|......| ::||:..||..
  Fly   189 KYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKR-IEDLMTACWKT 252

  Fly   926 EKEHRPQFARLLSLLEHLPK 945
            ..|.||....::.::..:.|
  Fly   253 VPEDRPSMQYIVGVMHEIVK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	65/276 (24%)
		Pkinase_Tyr	679..940	CDD:285015	64/268 (24%)
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	64/265 (24%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	63/269 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23257
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030