DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and Ksr2

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001299843.1	Gene:	Ksr2 / 333050	MGIID:	3610315	Length:	951	Species:	Mus musculus

Alignment Length:	1063	Identity:	340/1063 - (31%)
Similarity:	492/1063 - (46%)	Gaps:	272/1063 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMR--LNERIPANGLVP 97
            ::|:|||||.::||||||:||.|:.|||:|||.||||||:|||..|..|.:  |.||.......|
Mouse    26 LVQNMIDLSISNLEGLRTKCAASNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFP 90

  Fly    98 HTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAM 162
                 :||.|.|:|.:.:..|........:||..|.::||::.:.:....:  .:||..||..::
Mouse    91 -----QLRHWFRIVDVRKEVLEEISPDQLSLEDLLEMTDEQVCETVEKYGA--NQEECARLNASL 148

  Fly   163 QNLRKCMESLESGTAASNNDPEQW--HWDS-----------------WDRPTHIHRGSVGNIGLG 208
            ..||...:|      ..|...:.|  .|.:                 |.| ||:
Mouse   149 SCLRNVHKS------GGNLSKQDWIIQWPTTEPGQESNPVCPPEPSPWIR-THL----------- 195

  Fly   209 NNSTASPRTHHR--QHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTL----TLTPSPP 267
               :.|||...:  ||              |.....:|....   .||..:||:    .|.|.||
Mouse   196 ---SQSPRVQTKCPQH--------------FCPTSPTPGTPV---YTQVDRLTVDAYPNLCPPPP 240

  Fly   268 --------------------NSPFTPSSGLSSSLNGTPQRSR-------GTPPP-ARKHQTLL-- 302
                                ..|.||:...:.:..|||...|       ||||| :||...|:
Mouse   241 PLESGHRSLPPSPRQRHVVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPG 305

  Fly   303 ------SQSHVQVDGEQLARNRLPTDPSPDS-----------HSSTSS----------------- 333
                  |:||     |....||:....:|.:           ||...|
Mouse   306 FTALHRSKSH-----EFQLGNRVDEANTPKAKKKSKPLNLKIHSGVGSCENIPAQQRSPLLSERS 365

  Fly   334 --DIFVD-----PNTNA--SSGGSSSNVLMVP-CSPGVGHVGMGHAIKHRFTKALGFMATCTLCQ 388
              ..||.     |:|..  :....|:|.|.|| .||.:....:|::|||||:.......|||:|.
Mouse   366 LRSFFVGHGPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCG 430

  Fly   389 KQVFHRWMKCTDCKYICHKSCAPHVPPSC-------GLPREYV-------DEFRHIKEQGGYASL 439
            |.:.. .:||.:||..||..|....|| |       |.|...|       |....:::...|:.|
Mouse   431 KGMLF-GLKCKNCKLKCHNKCTKEAPP-CHLLIIHRGDPARLVRTESVPCDINNPVRKPARYSDL 493

  Fly   440 PHVHGAAKGSPLVKKSTLGK---PLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSS 501
             |:     ...|.|.:.:.|   |:..|...||:|||: |||||||||      ..|..:.:..|
Mouse   494 -HI-----SQTLPKTNKINKDHIPVPYQPDSSSNPSST-TSSTPSSPA------PPLPPSATPPS 545

  Fly   502 ANLLPTPSLGKHQPS-------------QFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATA 553
            . |.|:|...:.:.:             ||.||:|.                ||||....||..
Mouse   546 P-LHPSPQCPRQKKNFNLPASHYYKYKQQFIFPDVV----------------PVPETPTRAPQV- 592

  Fly   554 NGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFT 618
                             ::...|||    ..|.|:                .|....|:..:...
Mouse   593 -----------------ILHPVTSN----TILEGN----------------PLLQIEVEPTSENE 620

  Fly   619 SEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLE 683
            ..:.:..:|.|..:.::||..::....|              :..|.||.|:|||||:..|.:.|
Mouse   621 ESHNEAEESEDEFEEMNLSLLSARSFPR--------------KASQTSIFLQEWDIPFEQLEIGE 671

  Fly   684 RIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPY 748
            .||:||||.|:...|||:||::|::.: ..:|..|:.|:.||..::.|||||:||||||||:||:
Mouse   672 LIGKGRFGQVYHGRWHGEVAIRLIDIE-RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPH 735

  Fly   749 LAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKV 813
            |||:||||||.|||:.:...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:||||
Mouse   736 LAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKV 800

  Fly   814 IITDFGLFSSTKLLYC---DMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTV 875
            :||||||||.:.:|..   |..|.:.:.|||:||||:||.|.|:....: |.|:.:|||::.||:
Mouse   801 VITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDK-LPFSKHSDVFALGTI 864

  Fly   876 WYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL 940
            ||||...|:.||.||||:||||:|.|||.:|:.:..|:::.|:|:.||.:|:|.||.|.:|:.:|
Mouse   865 WYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDML 929

  Fly   941 EHLPKKRLARSPSHPVNLSRSAE 963
            |.|||:.  |..|||.:..:|||
Mouse   930 EKLPKRN--RRLSHPGHFWKSAE 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	51/132 (39%)
		C1_1	368..419	CDD:278556	20/57 (35%)
		PK_KSR	678..946	CDD:270965	136/270 (50%)
		Pkinase_Tyr	679..940	CDD:285015	132/263 (50%)
Ksr2	NP_001299843.1	KSR1-SAM	24..152	CDD:290277	51/132 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..298		15/60 (25%)
		C1	414..456	CDD:237996	15/42 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..558		27/82 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..634		2/19 (11%)
		PK_KSR2	666..935	CDD:271055	136/270 (50%)
		Pkinase_Tyr	667..929	CDD:285015	132/263 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1919
Isobase	1	0.950	-	0	Normalized mean entropy	S4491
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm43722
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	O	PTHR23257
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3270
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.950