DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and Ripk1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001100820.1	Gene:	Ripk1 / 306886	RGDID:	1310158	Length:	658	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	77/321 - (23%)
Similarity:	125/321 - (38%)	Gaps:	95/321 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 QNSISLKEWDIPYGDLLLLERIGQGRFGTV----HRALWHGDVAVKLL---------NEDYLQDE 715
            |..:||....:...|||..:.:..|.||.|    ||.  ||.|.:|.:         ||..|::.
  Rat     2 QPDMSLDNIKMASDDLLERKDLDSGGFGKVSLCFHRT--HGFVILKKVYTGPNRAEYNEALLEEG 64

  Fly   716 HMLETFRSEVANFKNTRHENLVLFMGACMNP-PYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLL 779
            .|:.          ..||:.:|..:|..:.. .|..::..:.:||.:  ::.:.:|...::....
  Rat    65 KMMH----------RLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNLM--HVLKTKESVPLSVKGR 117

  Fly   780 IAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNW----- 839
            |..:|.:||.|||...:|||||:.:||.::.      ||      .:...|:|:.....|
  Rat   118 IIVEIIEGMHYLHDEGVIHKDLKPENILVDR------DF------HIKIADLGVASFKTWSKLTK 170

  Fly   840 -------------------LCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFT 885
                               |.|:|||.:..:. .||       |..||||||..|.:.:...:
  Rat   171 EEHNKQREASSVTKKNGGTLYYMAPEHLTDIN-TKP-------TEKSDVYSFAIVLWAIFANK-- 225

  Fly   886 FKDQPAESIIWQVGRGMKQSLANLQSG-------------RDVKDLLMLCWTYEKEHRPQF 933
               :|.|::|.     .:|.|..:.||             |::..|:..||....|.||.|
  Rat   226 ---EPYENVIC-----TEQFLVCINSGNRPNVEDILEFCPREIISLMERCWQTNPEDRPTF 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	74/307 (24%)
		Pkinase_Tyr	679..940	CDD:285015	73/306 (24%)
Ripk1	NP_001100820.1	PKc_like	23..290	CDD:419665	71/300 (24%)
Ripk1	NP_001100820.1	Death_RIP1	570..655	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910