Protein Alignment ksr and Ksr2

DIOPT Version :9

• Sequence 1: NP_001287177.1
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: XP_017454023.1
• Gene: Ksr2 / 288691
• RGDID: 1562674
• Length: 950
• Species: Rattus norvegicus
• Alignment Length: 1056
• Identity: 339/1056 - (32%)
• Similarity: 494/1056 - (46%)
• Gaps: 259/1056 - (24%)

  Fly    35 IIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMR--LNERIPANGLVP 97
            ::|:|||||.::||||||:||.|:.|||:|||.||||||:|||..|..|.:  |.||.......|
  Rat    26 LVQNMIDLSISNLEGLRTKCAASNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFP 90

  Fly    98 HTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAM 162
                 :||.|.|:|.:.:..|........:||..|.::||::.:.:....:.|  ||..||..::
  Rat    91 -----QLRHWFRIVDVRKEVLEEISPDQLSLEDLLEMTDEQVCETVEKYGANR--EECARLNASL 148

  Fly   163 QNLRKCMESLESGTAASNNDPEQW--HWDSWDRPTHIHRGSVGNIGLGNNSTASP------RTHH 219
            ..||...:|      ..|...:.|  .|.:.:.            |..:|....|      ||.
  Rat   149 SCLRNVHKS------GGNLSKQDWIIQWPTTEP------------GQESNPVCPPEPSPWIRTR- 194

  Fly   220 RQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGS-------QLTL----TLTPSPP------ 267
                       |:.|...:|  :.|......:.|.|:       :||:    :|.|.||
  Rat   195 -----------LSQSPRVQS--KCPQHFCHTSPTPGAPVYTHVDRLTVDAYQSLCPPPPLESGHR 246

  Fly   268 -------------NSPFTPSSGLSSSLNGTPQRSR-------GTPPP-ARKHQTLL--------S 303
                         ..|.||:...:.:..|||...|       ||||| :||...|:        |
  Rat   247 SLPPSPRQRHVVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRS 311

  Fly   304 QSHVQVDGEQLARNRLPTDPSPDS-----------HSSTSS-------------------DIFVD 338
            :||     |....||:....:|.:           ||...|                   ..||.
  Rat   312 KSH-----EFQLGNRVDEANTPKAKKKSKPLNLKIHSGVGSCENIPAQQRSPLLSERSLRSFFVG 371

  Fly   339 -----PNTNA--SSGGSSSNVLMVP-CSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRW 395
                 |:|..  :....|:|.|.|| .||.:....:|::|||||:.......|||:|.|.:.. .
  Rat   372 HGPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLF-G 435

  Fly   396 MKCTDCKYICHKSCAPHVPPSC-------GLPREYV-------DEFRHIKEQGGYASLPHVHGAA 446
            :||.:||..||..|....|| |       |.|...|       |....:::...|:.| |:
  Rat   436 LKCKNCKLKCHNKCTKEAPP-CHLLIIHRGDPARLVRTESVPCDINNPVRKPARYSDL-HI---- 494

  Fly   447 KGSPLVKKSTLGK---PLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTP 508
             ...|.|.:.:.|   |:..|...||:|||: |||||||||      ..|..:.:..|. |.|:|
  Rat   495 -SQTLPKTNKINKDHIPVPYQPDSSSNPSST-TSSTPSSPA------PPLPPSATPPSP-LHPSP 550

  Fly   509 SLGKHQPS-------------QFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSL 560
            ...:.:.:             ||.||:|.                ||||....||..
  Rat   551 QCPRQKKNFNLPASHYYKYKQQFIFPDVV----------------PVPETPTRAPQV-------- 591

  Fly   561 VSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTH 625
                      ::...|||    ..|.|:                .|....|:..:.....:.:..
  Rat   592 ----------ILHPVTSN----TILEGN----------------PLLQIEVEPTSENEEGHDEAE 626

  Fly   626 KSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRF 690
            :|.|..:.::||..::....|              :..|.||.|:|||||:..|.:.|.||:|||
  Rat   627 ESEDEFEEMNLSLLSARSFPR--------------KASQTSIFLQEWDIPFEQLEIGELIGKGRF 677

  Fly   691 GTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSL 755
            |.|:...|||:||::|::.: ..:|..|:.|:.||..::.|||||:||||||||:||:|||:|||
  Rat   678 GQVYHGRWHGEVAIRLIDIE-RDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSL 741

  Fly   756 CKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGL 820
            |||.|||:.:...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:||||:||||||
  Rat   742 CKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGL 806

  Fly   821 FSSTKLLYC---DMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICG 882
            ||.:.:|..   |..|.:.:.|||:||||:||.|.|:....: |.|:.:|||::.||:||||...
  Rat   807 FSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDK-LPFSKHSDVFALGTIWYELHAR 870

  Fly   883 EFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKR 947
            |:.||.||||:||||:|.|||.:|:.:..|:::.|:|:.||.:|:|.||.|.:|:.:||.|||:.
  Rat   871 EWPFKTQPAEAIIWQMGAGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRN 935

  Fly   948 LARSPSHPVNLSRSAE 963
              |..|||.:..:|||
  Rat   936 --RRLSHPGHFWKSAE 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	52/132 (39%)
		C1_1	368..419	CDD:278556	20/57 (35%)
		PK_KSR	678..946	CDD:270965	136/270 (50%)
		Pkinase_Tyr	679..940	CDD:285015	132/263 (50%)
Ksr2	XP_017454023.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1547
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1607
OMA	1	1.010	-	-		QHG45551
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm45798
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	O	PTHR23257
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970