DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and pck1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_593737.2	Gene:	pck1 / 2542293	PomBaseID:	SPAC17G8.14c	Length:	988	Species:	Schizosaccharomyces pombe

Alignment Length:	1066	Identity:	216/1066 - (20%)
Similarity:	377/1066 - (35%)	Gaps:	296/1066 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NNNAPASAPDTGSTNANDPISGSLSVDSNLVI-IQDMIDLSANHLEGLRTQCAISSTLTQQEIRC 67
            |:..|.| |:..||.... :...||::...|. |:.::.|.:...:. :|...|.....:|::..
pombe   107 NSEKPLS-PEKISTMLQH-LQMRLSIEQQCVSGIEKIMSLYSKEQKD-KTDVIIKLKEGKQKVNL 168

  Fly    68 LESKLVRYFSELLLAKMRLNE-RIPANGLVPHTTGNELRQWLRVVGLSQ---GTLTACLARLTTL 128
            |:..|.||           || .||.:...|.:...:....|...||::   |||...:..|..:
pombe   169 LKRSLKRY-----------NELHIPFDISTPSSEEKQQASGLNFRGLAKPISGTLKVTIHSLRNI 222

  Fly   129 EQSLRLSDEEIRQLLADSPSQR----EEEELRRLTRAMQNLRKCMESLESGTAASNNDPEQWHWD 189
            |.:..|.......     ||..    ::.::.: :|..|.                        |
pombe   223 EHTSFLQTHSFTM-----PSYAVLYVDDAQVAK-SRISQT------------------------D 257

  Fly   190 SWDRP--THIHRGSVGNIGLGNNS---------TASPRTHHRQHGVKGKNSALANSTNFK-SGRQ 242
            :||..  ..:||.....|.:....         ...|.|...:...:.:|....:.|::| |..:
pombe   258 TWDETFIFDVHRAKEFQIIIYEKKKDFDIPIALILIPTTIIAEELRRKRNIQEMSETSWKPSIAE 322

  Fly   243 SPSATEELNSTQGSQLTLTLTPSPPNSPFTPSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHV 307
            |.|.::|    :||:      ..|.|:|           |.:...|..:|.....:..|||:|.:
pombe   323 SASRSDE----KGSK------SDPINAP-----------NSSSSISTNSPLAPTAYYKLLSKSWL 366

  Fly   308 QVDGEQLARNRLPTDP---SPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHA 369
            .::         |...   |......|:...|  |.|.....|:.........:..|||    ..
pombe   367 SLE---------PVGQICISLSFSKRTTKRQF--PETGLGRQGAIRQKKEDVVASQVGH----QF 416

  Fly   370 IKHRFTKALGFMATCTLCQKQV-FHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQ 433
            ::.:|.:.:    .|.:|.:.. :...::|.:|.::|||.|...|..||      :.:....|..
pombe   417 VQRQFYQIM----RCAVCAELFSYSPGLQCENCSFVCHKKCVTKVLASC------IAQSNSEKSD 471

  Fly   434 -GGYA-SLPHVHGAAKGSPLVKKSTLGK----------PLHQQ------------HGDSSSPSSS 474
             ||.. .:||     :..|.   ::||.          ||.::            ||       .
pombe   472 FGGLRYRIPH-----RFEPF---NSLGAQWCAHCGFFLPLRRKDCFKCVECGITCHG-------Q 521

  Fly   475 CTSSTPSSPALFQQRERELDQAGSSSSA--NLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLI 537
            |....|             |..|.|:..  .||....:.| :|.:...||.
pombe   522 CAHLIP-------------DYCGMSNDLKHQLLTELEVSK-RPKKPELPNQ-------------- 558

  Fly   538 SNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFF 602
            .|:...|:....|.::....|:|.:.|.|.:             |||   ..|.|...||.....
pombe   559 ENKTTNEKVYRKPLSSQNTFDTLPTISQGLL-------------AAT---QPVTSVLNTSPLPKT 607

  Fly   603 PRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSI 667
            |.|..:..|   ||.:|  |.|..|..:..: |.|.|:|.|::|:.......|       ::|.:
pombe   608 PEKDRSLNV---TPSSS--TPTPASVLAPPS-SASLSSSKDANRSVPESPRRE-------KKNRV 659

  Fly   668 SLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGD---VAVKLLNEDYLQDEHMLETFRS-----E 724
            :|       .|...|..:|:|.||.|..|.:..:   .|:|:|.::.:.....||:.::     |
pombe   660 TL-------DDFTFLAVLGKGNFGKVMLAEYKVNKKFYAIKVLKKEAILKNEELESLKTEKHVFE 717

  Fly   725 VANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMG 789
            |||  ..:|..|:....:......:..|.....|..|  .:|.:|::|::.|......::...:.
pombe   718 VAN--KEKHPFLLNLFASFQTSTRVYFVMEYILGGDL--MVHIQRQQFSVKRARFYGAEVCLALK 778

  Fly   790 YLHAREIIHKDLRTKNIFI-ENGKVIITDFGLFSSTKLL------YCDMGLGVPHNWLCYLAPEL 847
            |.|...|.::||:..||.: .:|.:.|.|:||.....||      :|    |.|.    ::|||:
pombe   779 YFHENGIAYRDLKLDNILLCPDGHIRIADYGLCKENMLLGNTTSTFC----GTPE----FMAPEI 835

  Fly   848 IRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFK--------------------DQPAE 892
            :...|..|.          .|.::||.:.|:::.|:..||                    :.||:
pombe   836 LLEQQYSKD----------VDWWAFGVLMYQMLLGQSPFKGEDEEEIFDAILSDEPLFPINMPAD 890

  Fly   893 SIIWQVGRGMKQSLANLQSGRDVKD---------LLMLCW--TYEKEHRPQFARLLS---LLEHL 943
            ::  .:.||:.....|.:.|...||         ...:.|  .|.|.:.|.:..|::   .|.:.
pombe   891 AV--SLLRGLLTRDPNQRLGSGPKDANEVMAHPFFASIVWDDLYNKLYEPSYKPLINDPRDLNNF 953

  Fly   944 PKKRLARSPS-HPVN--LSRSAESVF 966
            .::..:..|: .|||  |:|..:..|
pombe   954 DEEFTSACPTLTPVNTVLTRQQQECF 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	28/141 (20%)
		C1_1	368..419	CDD:278556	12/51 (24%)
		PK_KSR	678..946	CDD:270965	69/316 (22%)
		Pkinase_Tyr	679..940	CDD:285015	67/309 (22%)
pck1	NP_593737.2	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1	111..180	CDD:294066	19/82 (23%)
		C2	212..316	CDD:301316	18/133 (14%)
		C1_1	414..462	CDD:278556	13/61 (21%)
		C1_1	481..533	CDD:278556	12/79 (15%)
		S_TKc	664..923	CDD:214567	62/282 (22%)
		STKc_PKC	668..983	CDD:270722	74/336 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000