Protein Alignment ksr and Ripk3

DIOPT Version :10

• Sequence 1: NP_524236.2
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_647558.2
• Gene: Ripk3 / 246240
• RGDID: 628899
• Length: 478
• Species: Rattus norvegicus
• Alignment Length: 296
• Identity: 82/296 - (27%)
• Similarity: 127/296 - (42%)
• Gaps: 56/296 - (18%)

  Fly   665 NSISLKEWDIPYGDLLLLERIGQGRFGTVHRA---LWHGDVAVKLLNEDYLQDEHMLETFRSEVA 726
            :||||    :...:|..|..:|:|.||.|.||   .|:.|||||::|.         :....||.
  Rat    12 SSISL----VGSEELENLGFVGKGGFGAVFRARHTAWNLDVAVKIVNS---------KKISREVK 63

  Fly   727 NFKNTRHENLVLFMGACMNPPY-----LAIVTSLCKGNTLYTYIHQR--REKFAMNRTLLIAQQI 784
            ...|.||||::|.:|...|..:     .|:||...:..:|...:...  |....:.|.|   :::
  Rat    64 AMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSGLLQPSCPRPWPLLCRLL---EEV 125

  Fly   785 AQGMGYLHA--REIIHKDLRTKNIFIE---NGKVIITDFGL--FSSTKLLYCDMGLGVPHNWLCY 842
            ..||.|||:  ..::|:||:..|:.::   :.|  :.||||  |..........|.......|.|
  Rat   126 VLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAK--LADFGLSTFQGGSQSGSGSGSRDSGGTLAY 188

  Fly   843 LAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICG---EFTFKDQPAESIIWQVGRGMKQ 904
            |||||:      ...|:.   :..|||||||.:.:.::.|   |...|.......:  ..|..:.
  Rat   189 LAPELL------DNDGKA---SKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAV--CNRQRRP 242

  Fly   905 SLANLQSG-------RDVKDLLMLCWTYEKEHRPQF 933
            .|..|...       ..:|:|:..||:.|.:.||.|
  Rat   243 PLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSF 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_524236.2	SAM_KSR1_N	33..86	CDD:466555
		SAM_KSR1	92..166	CDD:463916
		C1_KSR	370..418	CDD:410362
		PK_KSR	678..946	CDD:270965	78/283 (28%)
Ripk3	NP_647558.2	Protein Kinases, catalytic domain	28..285	CDD:473864	76/276 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..330
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..429
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250|UniProtKB:Q9Y572	437..461
		RHIM	438..458	CDD:463679