DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and ksr-1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_509396.1	Gene:	ksr-1 / 181082	WormBaseID:	WBGene00002239	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	991	Identity:	260/991 - (26%)
Similarity:	399/991 - (40%)	Gaps:	300/991 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IIQDMIDLSANHLEGLRTQCAISSTLT---QQEIRCLESKLVRYFSELL-LAKMRLNERIPANGL 95
            |.||:...:.|:|:.......|:..||   :::.:.:|.|:   ||.:. :.|:.|.:|
Worm    22 IAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKI---FSAVYQMTKIGLIDR------ 77

  Fly    96 VPHTTGNELRQ----WLRVVGLS-QGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEEL 155
                   |.|:    |...|||| |......:..:|.......::::|:|. |||. .:.:.|..
Worm    78 -------EKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRS-LADR-GRLDVETK 133

  Fly   156 RRLTRAMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHR 220
            |:|             |:|.....|      ||:::                          |.|
Worm   134 RKL-------------LQSTVILQN------HWNAY--------------------------HSR 153

  Fly   221 QHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSP----PNSPFTPSSGLSSSL 281
                     ..:.||:..||:.:|:               .:||||    |:...|.:..:.||.
Worm   154 ---------TSSGSTDEPSGQSTPA---------------IVTPSPKFNVPSLSVTSAKMIQSSS 194

  Fly   282 NGTPQRSRGTPPPARKHQTLLSQSHVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPNTNASSG 346
            .|.     .|.|.:.|                                 |||.:.
Worm   195 MGF-----ATTPKSPK---------------------------------TSSRLV---------- 211

  Fly   347 GSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFM----ATCTLCQKQV----FHRWMKCTDCKY 403
                                 |||.|::.::..|.    |.|..||:.:    .:.|.||..||:
Worm   212 ---------------------HAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKW 255

  Fly   404 ICHKSCAPHVPPSCGLPREYV----DEFRHIKEQGGYASLPHVHGAAKGSPLVKKS-TLGKPLHQ 463
            ..|..|...|..||||..:::    |:.  |:|..|        |..|....|..| ::.:|..|
Worm   256 KVHTQCKGRVGDSCGLTPDHLRFLFDKL--IQENNG--------GMWKDPQSVPGSRSMNEPAFQ 310

  Fly   464 QHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSS 528
            ....:...|||..||.||:|||         .||.|.:.:.|..|...:.   :|.||:.
Worm   311 FPDTAIDSSSSTNSSAPSTPAL---------PAGISGNVSSLTAPYRSER---KFLFPDT----- 358

  Fly   529 GGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSL-IGSQTS--NASTAATLTGSLV 590
                     .|..|..:.|.           ||.|...|.::. |..:|.  |.|.||:::|::
Worm   359 ---------ENYSVHNRLPI-----------LVISEGDHPTTTEIQQETENHNKSAAASMSGNI- 402

  Fly   591 NSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTP------- 648
                                         |...|..:|..|.|    ||...||:..|
Worm   403 -----------------------------ESEGTIVANHEDST----GSQEVDSEAAPSQEAVDK 434

  Fly   649 --VRVD------------STEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWH 699
              .|.|            ||..|.:.|...|.::::...|.:.....:  ||:||||.|.|...:
Worm   435 FNKRADGGFTWERHAWNMSTIRGPNAQASWNEVTIQFETIEFDKQAPI--IGRGRFGKVLRGFHY 497

  Fly   700 GDVAVKLLNEDYLQD-EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGN-TLY 762
            ||||||:...:::.| ....|.|:.||:.:|||||:|:.||:|..|:.....:|.||.||: :||
Worm   498 GDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLY 562

  Fly   763 TYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIEN-GKVIITDFGLFSSTKL 826
            |.:|..|||..:..|..|||||.|.:.|||.::|:|||||:|||.:|: .||:|||||:.|..:|
Worm   563 TLLHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRL 627

  Fly   827 LYCDMGLG--VPHNWLCYLAPELIRALQPEKPRGECLEFTPY---SDVYSFGTVWYELICGEFTF 886
            .:.....|  ....|..|:||||..|::.|....||.:| |:   ||||:||.||:|::.|...:
Worm   628 AHPKQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDF-PFSENSDVYAFGCVWFEMLTGALPY 691

  Fly   887 KDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKK-RLAR 950
            ..:....|::...:|::..|.|::..:::|:||:.||....:.||....:...|..|||| |:.|
Worm   692 AGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKLTALPKKPRVNR 756

  Fly   951 SPSHPVNLSRSAESVF 966
            |||.|| :.:|.||.|
Worm   757 SPSFPV-MMKSYESTF 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	32/139 (23%)
		C1_1	368..419	CDD:278556	19/58 (33%)
		PK_KSR	678..946	CDD:270965	107/275 (39%)
		Pkinase_Tyr	679..940	CDD:285015	104/268 (39%)
ksr-1	NP_509396.1	C1	216..269	CDD:237996	14/52 (27%)
		Pkinase_Tyr	474..741	CDD:285015	105/269 (39%)
		PKc_like	482..751	CDD:304357	107/271 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164747
Domainoid	1	1.000	189	1.000	Domainoid score	I1950
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I2099
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm14357
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3270
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.830