DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and Limk1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_036020724.1	Gene:	Limk1 / 16885	MGIID:	104572	Length:	702	Species:	Mus musculus

Alignment Length:	726	Identity:	146/726 - (20%)
Similarity:	230/726 - (31%)	Gaps:	233/726 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 CTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKG 448
            |..|...:.|::.: .|.:..|.|........||....|::.:           .|..|.|..|.
Mouse    52 CCECSVSLSHQYYE-KDGQLFCKKDYWARYGESCHGCSEHITK-----------GLVMVAGELKY 104

  Fly   449 SP-----LVKKSTLGKPLHQQHGD-------SSSPSSSCTSSTPSSPALFQQRERELDQAGSSSS 501
            .|     |...:.:|      .||       |......|...|..:|.:.|
Mouse   105 HPECFICLACGNFIG------DGDTYTLVEHSKLYCGQCYYQTVVTPVIEQ-------------- 149

  Fly   502 ANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNG 566
              :|| .|.|.|.|......::..::.|..|    :|....|...|....|.:.....:.....|
Mouse   150 --ILP-DSPGSHLPHTVTLVSIPASAHGKRG----LSVSIDPPHGPPGCGTEHSHTVRVQGVDPG 207

  Fly   567 HMSSLIGSQTSNASTAATLTGS------------LVNSTT--TTSTCSFFPR-KLSTAGVDKRTP 616
            .||..:.:..........:.|:            |:..|:  ...|....|. .|....|...:|
Mouse   208 CMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSP 272

  Fly   617 FTSE-YTDTHKSNDS--DKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPY-- 676
            .:|. :|.:.::..|  .|.|..|.|..|....:.:...:::..|.|:    |.||:....|:
Mouse   273 LSSPVHTPSGQAASSARQKPVLRSCSIDTSPGTSSLASPASQRKDLGR----SESLRVVCRPHRI 333

  Fly   677 ---GDLLLLERIGQGRFG----TVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHE 734
               .||:..|.:|:|.||    ..||..  |:|.|  :.|....||....||..||...:...|.
Mouse   334 FRPSDLIHGEVLGKGCFGQAIKVTHRET--GEVMV--MKELIRFDEETQRTFLKEVKVMRCLEHP 394

  Fly   735 NLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHK 799
            |::.|:|.......|..:|...||.||...|.....::..::.:..|:.||.||.|||:..|||:
Mouse   395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 459

  Fly   800 DLRTKNIFI-------------------------------------------------------- 808
            ||.:.|..:
Mouse   460 DLNSHNCLVREPSQTPPEVAQATQAAATTATVCGQGHLGRLLELETWQRHVRGGQEDKRQSAPSL 524

  Fly   809 ENGKVIITDFGLFSSTKLLYCDMG-------------------LGVPHNWLCYLAPELIRALQPE 854
            :|..|::.||||   .:|:..:..                   :|.|:    ::|||:|..
Mouse   525 QNRNVVVADFGL---ARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPY----WMAPEMING---- 578

  Fly   855 KPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLL 919
                  ..:....||:|||.|    :|           .||.:|..........:..|.:|:..|
Mouse   579 ------RSYDEKVDVFSFGIV----LC-----------EIIGRVNADPDYLPRTMDFGLNVRGFL 622

  Fly   920 ----------------MLCWTYEKEHRPQFARLLSLLE--------HLP----KKRLARS----- 951
                            :.|...:.|.||.|.:|...||        |||    .::|.|.
Mouse   623 DRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLSGHLPLGPQLEQLERGFWETY 687

  Fly   952 -------PSHP 955
                   |:||
Mouse   688 RRGESSLPAHP 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556	8/34 (24%)
		PK_KSR	678..946	CDD:270965	81/374 (22%)
		Pkinase_Tyr	679..940	CDD:285015	75/355 (21%)
Limk1	XP_036020724.1	LIM1_LIMK1	5..77	CDD:188846	6/25 (24%)
		LIM2_LIMK1	84..138	CDD:188848	12/70 (17%)
		PDZ	165..255	CDD:395476	13/93 (14%)
		STKc_LIMK1	345..666	CDD:271123	75/356 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000