DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ksr and Raf1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001343262.1	Gene:	Raf1 / 110157	MGIID:	97847	Length:	668	Species:	Mus musculus

Alignment Length:	664	Identity:	204/664 - (30%)
Similarity:	295/664 - (44%)	Gaps:	160/664 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 VDPNTNASS-GGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTD 400
            :|.||:|:| .|....|..:...|...|    :..:..|.|    :|.|.:|||.:.:.: :|..
Mouse   112 LDWNTDAASLIGEELQVDFLDHVPLTTH----NFARKTFLK----LAFCDICQKFLLNGF-RCQT 167

  Fly   401 CKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQH 465
            |.|..|:.|:..||..|      || :.:|::                ..|...||:|
Mouse   168 CGYKFHEHCSTKVPTMC------VD-WSNIRQ----------------LLLFPNSTVG------- 202

  Fly   466 GDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQ-PSQFNFPNVTVTSSG 529
                      .|..|:.|:...:|.||        |.:.:|..|..::. |..|.| |.:..||.
Mouse   203 ----------DSGVPAPPSFPMRRMRE--------SVSRMPASSQHRYSTPHAFTF-NTSSPSSE 248

  Fly   530 GSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHM--------SSLIGSQTSNASTAATLT 586
            ||     :|..                 ....|:.|.||        |.:|.|.:.|||..|
Mouse   249 GS-----LSQR-----------------QRSTSTPNVHMVSTTLHVDSRMIESNSLNASPRA--- 288

  Fly   587 GSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLS----GSASTDSDRT 647
                        ||   |:....|.|.        ..:|..:.|...:|.|    ........:|
Mouse   289 ------------CS---RRFCLRGRDA--------IRSHSESASPSALSSSPNNLSPTGWSQPKT 330

  Fly   648 PVRVDSTEDGDSGQWRQNSI-------SLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVK 705
            ||.........||...:|.|       |...|:|...:::|..|||.|.||||::..||||||||
Mouse   331 PVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVK 395

  Fly   706 LLNEDYLQD--EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQR 768
            :|.   :.|  ...|:.||:|||..:.|||.|::|||| .|....|||||..|:|::||.::|.:
Mouse   396 ILK---VVDPTPEQLQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQ 456

  Fly   769 REKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVI-ITDFGLFSSTKLLYCDMG 832
            ..||.|.:.:.||:|.||||.||||:.|||:|:::.|||:..|..: |.||||.:..........
Mouse   457 ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ 521

  Fly   833 LGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTF-----KDQPAE 892
            :..|...:.::|||:|| :|.:.|      |:..|||||:|.|.|||:.||..:     :||
Mouse   522 VEQPTGSVLWMAPEVIR-MQDDNP------FSFQSDVYSYGIVLYELMAGELPYAHINNRDQ--- 576

  Fly   893 SIIWQVGRG-MKQSLANLQSG--RDVKDLLMLCWTYEKEHRPQFARLLS---LLEH-LPKKRLAR 950
             ||:.|||| ....|:.|...  :.:|.|:..|....||.||.|.::||   ||:| |||  :.|
Mouse   577 -IIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK--INR 638

  Fly   951 SPSHPVNLSRSAES 964
            |.|.| :|.|:|.:
Mouse   639 SASEP-SLHRAAHT 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556	15/50 (30%)
		PK_KSR	678..946	CDD:270965	117/282 (41%)
		Pkinase_Tyr	679..940	CDD:285015	112/274 (41%)
Raf1	NP_001343262.1	RBD_CRAF	55..131	CDD:340655	7/18 (39%)
		C1_1	139..184	CDD:365894	15/53 (28%)
		STKc_C-Raf	356..638	CDD:271051	121/298 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810