DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and Ksr1

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_006246986.1	Gene:	Ksr1 / 108348076	RGDID:	1308105	Length:	915	Species:	Rattus norvegicus

Alignment Length:	988	Identity:	316/988 - (31%)
Similarity:	447/988 - (45%)	Gaps:	228/988 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHTT 100
            :|.:||:|...|.||||:|::|:.|||||||.||:|||||..:...:|:.:.   |::......:
  Rat    44 LQKLIDISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQSKLSVT---PSDRTAELNS 105

  Fly   101 GNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQR---EEEELRRLTRAM 162
            ......||.:..:....:......| ||:..|.:.:.:.:::|     :|   ..||..||.:|:
  Rat   106 YPRFSDWLYIFNVRPEVVQEIPQEL-TLDALLEMDEAKAKEML-----RRWGASAEECSRLQQAL 164

  Fly   163 QNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSV---GNIGLGNNSTASPRTHHRQHGV 224
            ..|||.       |.......|...|.|.:........||   .::|....||..||
  Rat   165 TCLRKV-------TGLGGEHKEDSGWSSAEARESSSGPSVDMLSSLGRAGASTQGPR-------- 214

  Fly   225 KGKNSALANSTNFKSGRQSPSATEELNS------TQGSQLTLTLTPSPPNSPFTPSSGLSSSLNG 283
                 :::.|....|....|..:|.|:.      |.|     .|||...:|..||.:
  Rat   215 -----SISVSALPASDSPVPGLSEGLSDTCIPLHTSG-----RLTPRALHSFITPPT-------- 261

  Fly   284 TPQRSRGT--------PPPARKHQTLL--------SQSHVQVDGEQL-----ARNRLPTDPSPDS 327
            |||..|..        |||:||...||        |:||....|.::     .|..||
  Rat   262 TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVAPMRFELP------- 319

  Fly   328 HSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVF 392
            |.                            ||.:....:|..:.|||:........|.:|||.:.
  Rat   320 HG----------------------------SPQLVRRDIGLPVTHRFSTKSWLSQVCNVCQKSMM 356

  Fly   393 HRWMKCTDCKYICHKSCAPHVP-------PSCGLPR-EYVDEFRHIKEQGGYASLPHVHGAAKGS 449
            . .:||..|:..||..|....|       |...|.| |.|..  .|......|:.||.
  Rat   357 F-GVKCKHCRLKCHNKCTKEAPACRISFLPLARLRRTESVPS--DINNPVDRAAEPHF------- 411

  Fly   450 PLVKKSTLGKPL-HQQHG-----DSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTP 508
                 .||.|.| .::|.     ||||..||.|||||||||.|.       .:.:.|||...|.|
  Rat   412 -----GTLPKALTKKEHPPAMNLDSSSNPSSTTSSTPSSPAPFL-------TSSNPSSATTPPNP 464

  Fly   509 SLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIG 573
            |.|: :.|:||||......                                       |....|.
  Rat   465 SPGQ-RDSRFNFPAAYFIH---------------------------------------HRQQFIF 489

  Fly   574 SQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSG 638
            ...|....||.|      |:|..||......|....||.:......|...:...:|.|:...|..
  Rat   490 PDISACPQAAPL------SSTADSTRLDDQPKTDVLGVPEAEAEEPEAGKSEAEDDEDEIDDLPS 548

  Fly   639 SASTDSDRTPVRVDSTEDGDSGQWR--------QNSISLKEWDIPYGDLLLLERIGQGRFGTVHR 695
            |..                   .||        |.|:.|:|||||:..:.|.|.|||||:|.|||
  Rat   549 SRR-------------------HWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHR 594

  Fly   696 ALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNT 760
            ..|||:||::||..|....:| |:.|:.||.|::.|||||:|||||||||||:|||:||.|||.|
  Rat   595 GRWHGEVAIRLLEMDGHNQDH-LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRT 658

  Fly   761 LYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTK 825
            |::::...:....:|:|..|||:|.:|||||||:.|:||||::||:|.:||||:|||||||..:.
  Rat   659 LHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISG 723

  Fly   826 LL---YCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFK 887
            ::   ..:..|.:.|:||||||||::|.:.|.:...: |.|:..:|||:||||||||...::.||
  Rat   724 VVREERRENQLKLSHDWLCYLAPEIVREMIPGRDEDQ-LPFSKAADVYAFGTVWYELQARDWPFK 787

  Fly   888 DQPAESIIWQV--GRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLAR 950
            .||||::|||:  |.|:|:.||::..|::|.::|..||.::.:.||.|:.|:.:||.|||  |.|
  Rat   788 HQPAEALIWQIGSGEGVKRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDMLEKLPK--LNR 850

  Fly   951 SPSHPVNLSRSAE 963
            ..|||.:..:||:
  Rat   851 RLSHPGHFWKSAD 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	40/132 (30%)
		C1_1	368..419	CDD:278556	15/57 (26%)
		PK_KSR	678..946	CDD:270965	135/272 (50%)
		Pkinase_Tyr	679..940	CDD:285015	131/265 (49%)
Ksr1	XP_006246986.1	KSR1-SAM	41..168	CDD:290277	40/132 (30%)
		C1	336..378	CDD:237996	13/42 (31%)
		STKc_KSR1	577..855	CDD:271054	139/281 (49%)
		Pkinase_Tyr	578..842	CDD:285015	131/265 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1547
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1607
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146946at33208
OrthoFinder	1	1.000	-	-		FOG0002339
OrthoInspector	1	1.000	-	-		otm45798
orthoMCL	1	0.900	-	-		OOG6_105530
Panther	1	1.100	-	-	LDO	PTHR23257
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1770
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970