DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ksr and araf

DIOPT Version :9

Sequence 1:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_031746913.1	Gene:	araf / 100495479	XenbaseID:	XB-GENE-5755831	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	797	Identity:	223/797 - (27%)
Similarity:	324/797 - (40%)	Gaps:	223/797 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLT----PSP----PNSPFTPSSG 276
            |.|...|   ||||..       ..|.:.||.  :||.:.|:..    |:|    |....:||.|
Frog     3 RSHTPPG---ALANGA-------LHSLSRELG--KGSAVMLSAAVLELPNPGTRVPAQQESPSRG 55

  Fly   277 LSSS--------LNGT-----PQRSR---GTPPPARKHQTL--------LSQSHVQVDGEQLARN 317
            .|.|        ..||     |.:.|   ...|....:.:|        |||....|......|.
Frog    56 ASVSEYPHAEGKSGGTVKVYLPNQQRTVVNVRPGMTVYDSLDKALKVRGLSQECCAVYRLIQGRK 120

  Fly   318 RLPTDPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLM-VPCSPGVGHVGMGHAIKHRFTKALGF- 380
            .| ||...|.......::.|:             ||. ||.|            .|.|.:...|
Frog   121 AL-TDWETDITPLVGEELMVE-------------VLADVPLS------------MHNFVRKTHFT 159

  Fly   381 MATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGA 445
            :|.|..|.|.:||.: :|..|.|..|:.|:..||.:|      ||          .|.||
Frog   160 LAFCDFCLKFLFHGF-RCQTCGYKFHQHCSSKVPTAC------VD----------MAKLP----- 202

  Fly   446 AKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSL 510
               .||.       ||..|  |..|.....|...|.||   |.........||:|.:  .|
Frog   203 ---KPLT-------PLSYQ--DFQSYYEHPTVHLPLSP---QPPSPRTQHPGSASFS--FP---- 246

  Fly   511 GKHQPSQ----FNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSL 571
            |:.||.|    .:.|||.:.|:.|.     :.|..:.|...:|..|...|
Frog   247 GEGQPLQRHRSTSTPNVHIDSTTGP-----VDNSIIEEALRSAAVTPVDG--------------- 291

  Fly   572 IGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFT---SEYTDTHKSNDSDKT 633
                                           |.| |...:..::|.|   ||.|...|::.||:.
Frog   292 -------------------------------PPK-SAQPLGSKSPQTKSPSETTRERKTSASDEK 324

  Fly   634 VSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALW 698
            ..:......||              |..|..||          .::::|:|||.|.||||:|..|
Frog   325 KKVKQLGYRDS--------------SYYWEVNS----------SEVIILKRIGTGSFGTVYRGKW 365

  Fly   699 HGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYT 763
            |||||||:|.......| .::.|::|:...:.|||.|::|||| .|..|..||:|..|:|::||.
Frog   366 HGDVAVKILKVTNPTSE-QIQAFKNEMQVLRKTRHVNILLFMG-FMTRPQFAIITQWCEGSSLYR 428

  Fly   764 YIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVI-ITDFGLFSSTKLL 827
            ::|....:|.:.:.:.||:|.||||.||||:.|||:||::.|||:..|..: |.||||.:.....
Frog   429 HLHVIETRFDIFQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRW 493

  Fly   828 YCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTF-----K 887
            .....:..|...:.::|||:|| :|...|      ::..||||::|.|.|||:.|...:     :
Frog   494 SGSQQVEQPSGSILWMAPEVIR-MQESSP------YSSQSDVYAYGVVLYELMAGLLPYANINNR 551

  Fly   888 DQPAESIIWQVGRG-MKQSLANLQSG--RDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPK--KR 947
            ||    ||:.|||| :...|:.:.:.  :.:|.||:.|..:::|.||.|.::||.:|.|.:  .:
Frog   552 DQ----IIFMVGRGYLTPDLSKVSNNCPKAMKRLLVNCLKFKREERPLFPQILSSIELLQRALPK 612

  Fly   948 LARSPSHPVNLSRSAES 964
            :.||.|.| :|.|:..|
Frog   613 IERSASEP-SLHRAVNS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556	17/51 (33%)
		PK_KSR	678..946	CDD:270965	105/278 (38%)
		Pkinase_Tyr	679..940	CDD:285015	103/269 (38%)
araf	XP_031746913.1	RBD_ARAF	70..142	CDD:340653	16/85 (19%)
		C1_A_C-Raf	147..198	CDD:410420	20/79 (25%)
		PKc_like	345..609	CDD:419665	105/276 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000