DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcs and HCS2

DIOPT Version :9

Sequence 1:	NP_001287175.1	Gene:	Hcs / 40659	FlyBaseID:	FBgn0037332	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001320617.1	Gene:	HCS2 / 840632	AraportID:	AT1G37150	Length:	344	Species:	Arabidopsis thaliana

Alignment Length:	303	Identity:	89/303 - (29%)
Similarity:	154/303 - (50%)	Gaps:	45/303 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 DDKPPVANNNVLPI----------------LIHSCPDDFSTVDYFDNLKTEHIGRLVIYAPVVSS 799
            |....:.|||||.:                |:......|:...:.:::.|...||.:|::|.:||
plant    20 DTATRLKNNNVLKLPDNSKVSIFLQSEIKNLVRDDDSSFNLSLFMNSISTHRFGRFLIWSPYLSS 84

  Fly   800 SMHLINNLELIHGLAVLPVQ-------QTSGVGRRNNQWLSPPGCAMFSLQLHLTMDSALSSRLP 857
            :..:::     |..:.:||.       |..|.||..|.|.||.||.|:|..|.:. |..:   :|
plant    85 THDVVS-----HNFSEIPVGSVCVSDIQLKGRGRTKNVWESPKGCLMYSFTLEME-DGRV---VP 140

  Fly   858 LLQHLVGTAIVNSLRS-HEEYGVL--DISIKWPNDIYANGNQKIGGLVINTTLQGSQAIVNIGSG 919
            |:|::|..|:..:::. .::.|:.  |:.||||||:|.|| .||||::..:|.:..:.:|::|.|
plant   141 LIQYVVSLAVTEAVKDVCDKKGLSYNDVKIKWPNDLYLNG-LKIGGILCTSTYRSRKFLVSVGVG 204

  Fly   920 INLNNSRPTVCINDLIREYNTRVPNNKLPILKYELLIAMIFNEIERLLGEVQNGDFDSFYALYYS 984
            :|::|.:||.|:|.::::  ...|:|   :||.|.::...|.:.|..........|.|...|||.
plant   205 LNVDNEQPTTCLNAVLKD--VCPPSN---LLKREEILGAFFKKFENFFDLFMEQGFKSLEELYYR 264

  Fly   985 LWLHSGQSVKICLQKDQEKEAE-IVGIDDFGFLEVKLPTGTIE 1026
            .||||||.| |..:|::::..: :|.|.  |:.|......|:|
plant   265 TWLHSGQRV-IAEEKNEDQVVQNVVTIQ--GWSEENYEPETLE 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	293..437	CDD:284736
		GAT_1	456..>509	CDD:294025
		BPL_LplA_LipB	793..921	CDD:301309	44/137 (32%)
		BirA2	812..1037	CDD:223417	73/226 (32%)
		BPL_C	988..1037	CDD:280411	13/40 (33%)
HCS2	NP_001320617.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I3357
eggNOG	1	0.900	-	-		E1_COG0340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392751at2759
OrthoFinder	1	1.000	-	-		FOG0003219
OrthoInspector	1	1.000	-	-		otm2925
orthoMCL	1	0.900	-	-		OOG6_100546
Panther	1	1.100	-	-	O	PTHR12835
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.820