DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcs and HLCS

DIOPT Version :9

Sequence 1:	NP_001287175.1	Gene:	Hcs / 40659	FlyBaseID:	FBgn0037332	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001339443.1	Gene:	HLCS / 3141	HGNCID:	4976	Length:	873	Species:	Homo sapiens

Alignment Length:	1012	Identity:	270/1012 - (26%)
Similarity:	431/1012 - (42%)	Gaps:	245/1012 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CLRPLQTLH-ITPWISFPPAPSLLPFSYAADTLTPASTPTEADVPRQQRVSLSAQGEERMQLLLE 142
            |:...|::. :..|..|..:|.:|...:.|..       ||         |:..|.|.
Human    60 CVSDSQSIEDLNKWALFLVSPFILEAEHIAFV-------TE---------SIWVQSEN------- 101

  Fly   143 ADIEPLQRPSSEDTSAVRLEDYGKLIAWKIDSHLAVLIETDVEHFTKLLITTFLRNNLCINDQLP 207
                 |||.||.:| .|:..|....:|.:......::.|..|::|:||.: .|:.:.|.:::.|
Human   102 -----LQRSSSSET-IVKWSDCCLPLACRPGDPYRLIAEASVDNFSKLGV-AFMEDRLHMDNGL- 158

  Fly   208 LLRIESVQREGDPQPFELLAKHLKRQSRISVGLDKDGWKKHMEDLRAVGVLAHQATEFEYQRNRS 272
                         .|.::::.||           :|...|.::|    .|...||...|.:...|
Human   159 -------------VPQKIVSVHL-----------QDSTLKEVKD----QVSNKQAQILEPKPEPS 195

  Fly   273 -EGRTKSDPTTHDQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKAEAKGTSTKPFPTKSDAK 336
             |.:.:.|...|..|...:.|.:     ||..:                 :|::       |.::
Human   196 LEIKPEQDGMEHVGRDDPKALGE-----EPKQR-----------------RGSA-------SGSE 231

  Fly   337 PATLAKSEGTPATSKEDSKLTPTKGALKTSELEKLAAVQAAQQQKKEAVQVSPVKAAFLAKPPML 401
            ||..:...|.|.                  |...|......:..:.|...:..||.|
Human   232 PAGDSDRGGGPV------------------EHYHLHLSSCHECLELENSTIESVKFA-------- 270

  Fly   402 SKHDEPDKASDQPTKPRKSFEAVKPLNSPPSSRAAPSRPVLQRNKDSLQDAKPLNVLVY--SDSA 464
            |..:.||...|..:    |.|:|       :...:|.|   :..:.:|....| |:|:|  |||.
Human   271 SAENIPDLPYDYSS----SLESV-------ADETSPER---EGRRVNLTGKAP-NILLYVGSDSQ 320

  Fly   465 SAR---ESTLATLQQLLERNVYTIYPLMPQQAAQKYWTEQTALLVVC--GSVAHGIGQILVDYFL 524
            .|.   ....:.|...::.:.|.:|.|:...|.:..||:...|||:.  .|:...:.|..:.|..
Human   321 EALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLS 385

  Fly   525 QGGKVLSLCSDILHFVLPNYR-TAEVREHELVQ---FSYDKWQRVKM-MHHIFC-YQPSPVKKHF 583
            ||||||.|.|.   |....:: |::...|:.||   ||......||: :....| ||..||:
Human   386 QGGKVLGLSSS---FTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVR--- 444

  Fly   584 STDSEESTKSHSRKPALVCPRSMELKDLAGHSHNLD-----VHV-LGTEETWNTPSLMLAKSLQS 642
                    .|..|              |.||..|.|     ||| .||.
Human   445 --------LSPGR--------------LQGHLENEDKDRMIVHVPFGTR---------------- 471

  Fly   643 GGKAVFSQVHLEMNPSE--FESDETKYSILKQNERTRLEIFADL---LGKYLDVQ---------- 692
            ||:||..|||||:.||.  .::.| .:::||.:...|.|:..::   ||...|::
Human   472 GGEAVLCQVHLELPPSSNIVQTPE-DFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYL 535

  Fly   693 VRGGDGVDQPQPGVVYKHAYFLGRHEAKFELLEKLRLRCSGSDNVIATPNLTMKFCGKDDKPPVA 757
            :...:.:..|.       ..:||:|              ..|:..|.:..|:::|..........
Human   536 LSAAEEIRDPL-------MQWLGKH--------------VDSEGEIKSGQLSLRFVSSYVSEVEI 579

  Fly   758 NNNVLPILIHS---CPDDFSTVDYFDNLKTEHIGRLVIYAPVVSSSMHLINNL------ELIHGL 813
            ..:.:|::.:.   ..:.|:...|..||:|:.:|:::::|.|..::|.|::.|      |:  ||
Human   580 TPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEM--GL 642

  Fly   814 AVLPVQQTSGVGRRNNQWLSPPGCAMFSLQLHLTMDSALSSRLPLLQHLVGTAIVNSLRSHEEYG 878
            .|:..:||.|.||..|.||||.|||:.:|.:.:.:.|.|..|:|.:|||:..|:|.::||..||.
Human   643 IVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQ 707

  Fly   879 VLDISIKWPNDIYANGNQKIGGLVINTTLQGSQAIVNIGSGINLNNSRPTVCINDLIREYNTRVP 943
            .:::.:|||||||.:...||||:::|:||.|....:.||.|.|:.||.||:||||||.||| :..
Human   708 DINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYN-KQH 771

  Fly   944 NNKLPILKYELLIAMIFNEIERLLGEVQNGDFDSFYALYYSLWLHSGQSVKICLQKDQEKEAEIV 1008
            ..:|..|:.:.|||.:...:|:|:.|.|:...:|...|||..|:||||.|.  |...:..:..||
Human   772 KAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVH--LGSAEGPKVSIV 834

  Fly  1009 GIDDFGFLEVKLPTGTIEIVQPDGNSFDMLKGLIIPK 1045
            |:||.|||:|....|.:..|.|||||||||:.||:||
Human   835 GLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPK 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	293..437	CDD:284736	21/143 (15%)
		GAT_1	456..>509	CDD:294025	17/59 (29%)
		BPL_LplA_LipB	793..921	CDD:301309	54/133 (41%)
		BirA2	812..1037	CDD:223417	99/224 (44%)
		BPL_C	988..1037	CDD:280411	23/48 (48%)
HLCS	NP_001339443.1	GAT_1	349..607	CDD:320716	73/323 (23%)
		BPL	614..794	CDD:319741	74/182 (41%)
		BPL_C	816..863	CDD:280411	23/48 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154897
Domainoid	1	1.000	108	1.000	Domainoid score	I6454
eggNOG	1	0.900	-	-		E1_COG0340
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3133
Isobase	1	0.950	-	0	Normalized mean entropy	S3947
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392751at2759
OrthoFinder	1	1.000	-	-		FOG0003219
OrthoInspector	1	1.000	-	-		oto91302
orthoMCL	1	0.900	-	-		OOG6_100546
Panther	1	1.100	-	-	LDO	PTHR12835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R144
SonicParanoid	1	1.000	-	-		X2178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740