DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcs and Hlcs

DIOPT Version :9

Sequence 1:	NP_001287175.1	Gene:	Hcs / 40659	FlyBaseID:	FBgn0037332	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_038944721.1	Gene:	Hlcs / 288240	RGDID:	1565360	Length:	870	Species:	Rattus norvegicus

Alignment Length:	1108	Identity:	284/1108 - (25%)
Similarity:	444/1108 - (40%)	Gaps:	304/1108 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTLYYV----------SATVLQSWRIQKA--CS-KIAEHLAQPSSIAFYTLQSGSDDGFDPALA 52
            ::||.|:          :|.||.:.|..:|  || ......|||                    .
  Rat     2 LITLCYLYLWARWGRRPAALVLSTVRRLRASRCSFTFCRAAAQP--------------------G 46

  Fly    53 SSELCCNRNAAKVTDILWLHANQRGCCLRPLQTL-HITPWISFPPAPSLLPFSYAADTLTPASTP 116
            .:.:|.:|..             |..|:...|:: .:..|..|..:|.:|...:.|..
  Rat    47 GARVCLSRGG-------------RVFCVGESQSVDDLNKWALFLVSPFILEAEHIAFV------- 91

  Fly   117 TEADVPRQQRVSLSAQGEERMQLLLEADIEPLQRPSSEDTSAVRLEDYGKLIAWKIDSHLAVLIE 181
            ||         |:..||..            .|.|||.:|          ::.|
  Rat    92 TE---------SIWVQGTS------------FQEPSSSET----------VVKW----------- 114

  Fly   182 TDVEHFTKLLITTFLRNNLCINDQLPLLRIESVQREGDPQPFELLAK-HLKRQSRISVGLDKDGW 245
                            ::.|    |||     ..|.||  |::|:|| .:...|::.|...:|
  Rat   115 ----------------SDCC----LPL-----ACRPGD--PYQLIAKASVDNFSKLGVAFMED-- 150

  Fly   246 KKHMEDLRAVGVLAHQATEFEYQRNRSEGRTKSDPTTHDQRPTSELLAKAVAVVEPTNKAYLSPA 310
            :..|::    |::|.:..                 :.|.:.|..:.|:||      :||...:|.
  Rat   151 RLQMDN----GLIAQKIV-----------------SVHLKDPALKELSKA------SNKQVQAPL 188

  Fly   311 RTTEASLKAEA-------------KGTSTKPFPTKSDAKPATLAKSEGTPATSKEDSKLTPTKGA 362
            .:.||||:|:.             |.....|.|.:....|.:.:.::|.|...
  Rat   189 PSPEASLEAQPAQGVMEQAGQGDWKAAGEGPSPQRRGCAPVSESAADGDPGQG------------ 241

  Fly   363 LKTSELEKLAAVQAAQQQKKEAVQVSPVKAAFLAKPPMLSKHDEPDKASDQPTKPRKSFEAVKPL 427
              ::||.:|......:..:.|...:..|:.|               .|.:.|..|.....:|:
  Rat   242 --STELCQLHLSSCHECLELENSTIESVRCA---------------SAENIPDLPHDCSSSVE-- 287

  Fly   428 NSPPSSRAAPSRPVLQRNKDSLQDAKPLNVLVYSDSASARESTLATLQQL-------LERNVYTI 485
              ..:....|.|    :.|......|..|:|:|..|.|  |..|..|||:       ::.:.||:
  Rat   288 --GTAGELCPER----KGKRVNISGKAPNILLYVGSGS--EEALGQLQQVRSVLTDCVDTDSYTL 344

  Fly   486 YPLMPQQAAQKYWTEQTALLVVCG--SVAHGIGQILVDYFLQGGKVLSLCSDILHFVLPNYRTA- 547
            |.|:...|.:..|.:...|||:..  .:..||....:.|..||||||.|.|.   |...:.|.|
  Rat   345 YHLLEDSALRDPWPDNCLLLVIASRDPIPKGIHHRFMAYLSQGGKVLGLSSS---FTFGDLRVAR 406

  Fly   548 -EVREHELVQFSYDKWQ----RVKMMHHIFCYQPSPVKKHFSTDSEESTKSHSRKPALVCPRSME 607
             :|..:......:.|..    |:.::...:.|:..|                            .
  Rat   407 RDVLRNTAQNLVFSKADGSEVRLSVLSSGYVYEEGP----------------------------S 443

  Fly   608 LKDLAGHSHNLD-----VHV-LGTEETWNTPSLMLAKSLQSGGKAVFSQVHLEMNPS-EFESDET 665
            |..|.||..|.|     ||| .||.                ||:|:..|||||:.|| .......
  Rat   444 LGRLQGHLENEDKDKMIVHVPFGTH----------------GGEAILCQVHLELPPSAPLVQTTD 492

  Fly   666 KYSILKQNERTRLEIFADLLGKYLDVQVRGGDGVDQPQPGVVYKHAYFLGRHEAKFELLEKLRLR 730
            .:::||.:...|||:..::|...       |...|.||...:......|...|.:...::.| .|
  Rat   493 DFNVLKSSNTRRLEVLKEILTAL-------GLSCDAPQAPALTPLYLLLAAEEIQGPFMQWL-AR 549

  Fly   731 CSGSDNVIATPNLTMKFCGKDDKPPVANNNVLPILIHSCPDDFST-----VDYFDNLKTEHIGRL 790
            ....:.||.:..|::||............:.:|::  :.|:.||:     ..|..||::..:||:
  Rat   550 HVDPEGVIKSSKLSLKFVSSYTSEAEITPSSIPVV--TDPEGFSSEHFNLETYRQNLQSTRLGRV 612

  Fly   791 VIYAPVVSSSMHLINNL------ELIHGLAVLPVQQTSGVGRRNNQWLSPPGCAMFSLQLHLTMD 849
            :::|.|.|::|.|::.|      |:  ||..:.|:||.|.||..|.||||.|||:.:|.:.:.:.
  Rat   613 ILFAEVTSTTMSLLDGLMFEMPQEM--GLIAIAVRQTQGKGRGPNAWLSPVGCALSTLLVSIPLR 675

  Fly   850 SALSSRLPLLQHLVGTAIVNSLRSHEEYGVLDISIKWPNDIYANGNQKIGGLVINTTLQGSQAIV 914
            |.|..|:|.:|||:..|:|.::||..||..:::.:|||||||.:...||||:::|:||.|....:
  Rat   676 SQLGQRIPFVQHLMSLAVVEAVRSIPEYEDINLRVKWPNDIYYSDLMKIGGVLVNSTLVGETFYI 740

  Fly   915 NIGSGINLNNSRPTVCINDLIREYNTRVPNNK--LPILKYELLIAMIFNEIERLLGEVQNGDFDS 977
            .||.|.|:.||.||:||||||.|:|.:   ||  |..|:.:.|||.....:|:|:...|:...|.
  Rat   741 LIGCGFNVTNSNPTICINDLIEEHNKQ---NKAGLKPLQADCLIARAVTVLEKLIDRFQDQGPDG 802

  Fly   978 FYALYYSLWLHSGQSVKICLQKDQEKEAEIVGIDDFGFLEVKLPTGTIEIVQPDGNSFDMLKGLI 1042
            ...|||..|.||||.|:  |...:.....|||:||.|||:|....|.:..|.|||||||||:.||
  Rat   803 VLPLYYKYWAHSGQQVR--LGSSEGPAVSIVGLDDSGFLQVHQEGGGVVSVHPDGNSFDMLRNLI 865

  Fly  1043 IPK 1045
            :||
  Rat   866 VPK 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	293..437	CDD:284736	26/156 (17%)
		GAT_1	456..>509	CDD:294025	19/59 (32%)
		BPL_LplA_LipB	793..921	CDD:301309	55/133 (41%)
		BirA2	812..1037	CDD:223417	99/226 (44%)
		BPL_C	988..1037	CDD:280411	23/48 (48%)
Hlcs	XP_038944721.1	GAT_1	310..604	CDD:412116	83/352 (24%)
		BPL	611..795	CDD:319741	78/188 (41%)
		BPL_C	813..860	CDD:396696	23/48 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348767
Domainoid	1	1.000	106	1.000	Domainoid score	I6480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392751at2759
OrthoFinder	1	1.000	-	-		FOG0003219
OrthoInspector	1	1.000	-	-		oto98385
orthoMCL	1	0.900	-	-		OOG6_100546
Panther	1	1.100	-	-	LDO	PTHR12835
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2178
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900