Protein Alignment Hcs and Hlcs

DIOPT Version :10

• Sequence 1: NP_001287175.1
• Gene: Hcs / 40659
• FlyBaseID: FBgn0037332
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_038944719.2
• Gene: Hlcs / 288240
• RGDID: 1565360
• Length: 879
• Species: Rattus norvegicus
• Alignment Length: 1007
• Identity: 266/1007 - (26%)
• Similarity: 414/1007 - (41%)
• Gaps: 257/1007 - (25%)

  Fly    88 ITPWISFPPAPSLLPFSYAADTLTPASTPTEADVPRQQRVSLSAQGEERMQLLLEADIEPLQRPS 152
            :..|..|..:|.:|...:.|..       ||         |:..||..            .|.||
  Rat    79 LNKWALFLVSPFILEAEHIAFV-------TE---------SIWVQGTS------------FQEPS 115

  Fly   153 SEDTSAVRLEDYGKLIAWKIDSHLAVLIETDVEHFTKLLITTFLRNNLCINDQLPLLRIESVQRE 217
            |.:|          ::.|                           ::.|    |||     ..|.
  Rat   116 SSET----------VVKW---------------------------SDCC----LPL-----ACRP 134

  Fly   218 GDPQPFELLAK-HLKRQSRISVGLDKDGWKKHMEDLRAVGVLAHQATEFEYQRNRSEGRTKSDPT 281
            ||  |::|:|| .:...|::.|...:|  :..|::    |::|.:..                 :
  Rat   135 GD--PYQLIAKASVDNFSKLGVAFMED--RLQMDN----GLIAQKIV-----------------S 174

  Fly   282 THDQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKAEA-------------KGTSTKPFPTKS 333
            .|.:.|..:.|:||      :||...:|..:.||||:|:.             |.....|.|.:.
  Rat   175 VHLKDPALKELSKA------SNKQVQAPLPSPEASLEAQPAQGVMEQAGQGDWKAAGEGPSPQRR 233

  Fly   334 DAKPATLAKSEGTPATSKEDSKLTPTKGALKTSELEKLAAVQAAQQQKKEAVQVSPVKAAFLAKP 398
            ...|.:.:.::|.|...              ::||.:|......:..:.|...:..|:.|
  Rat   234 GCAPVSESAADGDPGQG--------------STELCQLHLSSCHECLELENSTIESVRCA----- 279

  Fly   399 PMLSKHDEPDKASDQPTKPRKSFEAVKPLNSPPSSRAAPSRPVLQRNKDSLQDAKPLNVLVYSDS 463
                      .|.:.|..|.....:|:    ..:....|.|    :.|......|..|:|:|..|
  Rat   280 ----------SAENIPDLPHDCSSSVE----GTAGELCPER----KGKRVNISGKAPNILLYVGS 326

  Fly   464 ASARESTLATLQQL-------LERNVYTIYPLMPQQAAQKYWTEQTALLVVCG--SVAHGIGQIL 519
            .|  |..|..|||:       ::.:.||:|.|:...|.:..|.:...|||:..  .:..||....
  Rat   327 GS--EEALGQLQQVRSVLTDCVDTDSYTLYHLLEDSALRDPWPDNCLLLVIASRDPIPKGIHHRF 389

  Fly   520 VDYFLQGGKVLSLCSDILHFVLPNYRTA--EVREHELVQFSYDKWQ----RVKMMHHIFCYQPSP 578
            :.|..||||||.|.|.   |...:.|.|  :|..:......:.|..    |:.::...:.|:..|
  Rat   390 MAYLSQGGKVLGLSSS---FTFGDLRVARRDVLRNTAQNLVFSKADGSEVRLSVLSSGYVYEEGP 451

  Fly   579 VKKHFSTDSEESTKSHSRKPALVCPRSMELKDLAGHSHNLD-----VHV-LGTEETWNTPSLMLA 637
                                        .|..|.||..|.|     ||| .||.
  Rat   452 ----------------------------SLGRLQGHLENEDKDKMIVHVPFGTH----------- 477

  Fly   638 KSLQSGGKAVFSQVHLEMNPS-EFESDETKYSILKQNERTRLEIFADLLGKYLDVQVRGGDGVDQ 701
                 ||:|:..|||||:.|| ........:::||.:...|||:..::|...       |...|.
  Rat   478 -----GGEAILCQVHLELPPSAPLVQTTDDFNVLKSSNTRRLEVLKEILTAL-------GLSCDA 530

  Fly   702 PQPGVVYKHAYFLGRHEAKFELLEKLRLRCSGSDNVIATPNLTMKFCGKDDKPPVANNNVLPILI 766
            ||...:......|...|.:...::.| .|....:.||.:..|::||............:.:|::
  Rat   531 PQAPALTPLYLLLAAEEIQGPFMQWL-ARHVDPEGVIKSSKLSLKFVSSYTSEAEITPSSIPVV- 593

  Fly   767 HSCPDDFST-----VDYFDNLKTEHIGRLVIYAPVVSSSMHLINNL------ELIHGLAVLPVQQ 820
             :.|:.||:     ..|..||::..:||::::|.|.|::|.|::.|      |:  ||..:.|:|
  Rat   594 -TDPEGFSSEHFNLETYRQNLQSTRLGRVILFAEVTSTTMSLLDGLMFEMPQEM--GLIAIAVRQ 655

  Fly   821 TSGVGRRNNQWLSPPGCAMFSLQLHLTMDSALSSRLPLLQHLVGTAIVNSLRSHEEYGVLDISIK 885
            |.|.||..|.||||.|||:.:|.:.:.:.|.|..|:|.:|||:..|:|.::||..||..:::.:|
  Rat   656 TQGKGRGPNAWLSPVGCALSTLLVSIPLRSQLGQRIPFVQHLMSLAVVEAVRSIPEYEDINLRVK 720

  Fly   886 WPNDIYANGNQKIGGLVINTTLQGSQAIVNIGSGINLNNSRPTVCINDLIREYNTRVPNNK--LP 948
            ||||||.:...||||:::|:||.|....:.||.|.|:.||.||:||||||.|:|.:   ||  |.
  Rat   721 WPNDIYYSDLMKIGGVLVNSTLVGETFYILIGCGFNVTNSNPTICINDLIEEHNKQ---NKAGLK 782

  Fly   949 ILKYELLIAMIFNEIERLLGEVQNGDFDSFYALYYSLWLHSGQSVKICLQKDQEKEAEIVGIDDF 1013
            .|:.:.|||.....:|:|:...|:...|....|||..|.||||.|:  |...:.....|||:||.
  Rat   783 PLQADCLIARAVTVLEKLIDRFQDQGPDGVLPLYYKYWAHSGQQVR--LGSSEGPAVSIVGLDDS 845

  Fly  1014 GFLEVKLPTGTIEIVQPDGNSFDMLKGLIIPK 1045
            |||:|....|.:..|.|||||||||:.||:||
  Rat   846 GFLQVHQEGGGVVSVHPDGNSFDMLRNLIVPK 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	268..437	CDD:369339	29/181 (16%)
		BPL_N	455..>533	CDD:462915	28/86 (33%)
		BirA2	791..1028	CDD:440109	99/244 (41%)
Hlcs	XP_038944719.2	None