Protein Alignment Hcs and Hcs

DIOPT Version :10

• Sequence 1: NP_001287175.1
• Gene: Hcs / 40659
• FlyBaseID: FBgn0037332
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_321640.5
• Gene: Hcs / 1281690
• VectorBaseID: AGAMI1_009497
• Length: 1056
• Species: Anopheles gambiae
• Alignment Length: 1121
• Identity: 419/1121 - (37%)
• Similarity: 605/1121 - (53%)
• Gaps: 142/1121 - (12%)

  Fly     1 MLTLYYVSATVLQSWRIQKACSKIAEHLAQPSSIAFYTLQSGSDDG---FDPALASSELCCNRNA 62
            :.||.|::.|:..|.|.:...:.|.:.|....:::|||..:| |||   .|...||:       .
Mosquito     2 LFTLVYIAITLRTSLRFRAIRNSIKKILTDRYAVSFYTASNG-DDGVTELDSPDASA-------G 58

  Fly    63 AKVTDILWLHANQRGCCLRPLQTLHITPWISFPPAPSLLPFSYAADTLTPASTPTEADVPRQQRV 127
            |.|:..:|...:||||.:.|::.:.:..|.:.|        ..||..|.|...|. :|...|..|
Mosquito    59 ANVSSCVWYLPDQRGCLVYPVRRITLADWYTIP--------EIAAPVLVPGPQPI-SDELVQLIV 114

  Fly   128 SLSAQGEERMQLLLEADIEPLQRPSSEDTSAVRLEDYGKLIAW--KIDSHLAVLIETDVEHFTKL 190
            :|.||  ||     .:|..|:......:..:|.|..:|:::||  :....|.:|:|||.....:|
Mosquito   115 TLEAQ--ER-----SSDQNPIGVKEQGEEDSVMLSRFGRVLAWRNRRSRSLDLLLETDATRTFQL 172

  Fly   191 LITTFLRNNLCIN-DQLPLLRIESVQREGDPQPFELLAKH------LKRQSRISVGLDKDGWKKH 248
            ::.||......:: .:|.|:::|||:..|:..|.     |      ||.|.|   .|..|.|
Mosquito   173 IVATFGSGRFGLDGGRLKLVQLESVETLGESMPL-----HEPDDALLKAQER---NLGTDAW--- 226

  Fly   249 MEDLRAV------------------------------------GVLAHQATEFEYQRNRSEGRTK 277
            :.||..|                                    |.:....:..:...:.|..|.:
Mosquito   227 LTDLLTVAERIENERCSTNYSGVGIQPDIIASNDIKISLELLDGTVVSSQSRADLLSSGSNSRNR 291

  Fly   278 SDPTTHDQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKAEAKGTSTKPFPT----------K 332
            |.....|...::.....:....||.....:|.:.|.|...:.|.|.:|  |.||          |
Mosquito   292 SQLDLTDGLMSTNGPNHSCPFEEPEPDGTVSRSTTDELIGETEQKASS--PCPTAVAKGDEEEKK 354

  Fly   333 SDA---KPATLAKSEGTPATSKEDSKLTPTKGALKTSELEKLAAVQAAQQQKKEAVQ--VSPVKA 392
            .||   .|.|:.  |...|.:||....||.  .::.||.|...||.:....|...|:  :.|.|
Mosquito   355 HDAVAEPPMTVV--EDVVANAKELKPTTPP--IVEPSEPEAKDAVISNGTVKHHPVREPLQPAK- 414

  Fly   393 AFLAKPPM-------LSKHDEPDKASDQPTKPRKSFEAVKPLNSPPSSRAAPSRPVLQRNKD-SL 449
               :.||:       .:|.:||.....:| ||.:|...    :|.||||       |:...| |.
Mosquito   415 ---SNPPLPVPASPSTAKPNEPIAVPAKP-KPTRSLRK----SSFPSSR-------LRLGTDQSG 464

  Fly   450 QDAKPLNVLVYSDSASARESTLATLQQLLERNVYTIYPLMPQQAAQKYWTEQTALLVVCGSVAHG 514
            ...||.|:||:|||:|..|..:|||..|||.|.|||||:...||....|.:.|.|::|.||:...
Mosquito   465 VVTKPPNILVHSDSSSTMEYVIATLNNLLEPNTYTIYPITAGQAIAASWLQSTVLIIVAGSLDME 529

  Fly   515 IGQILVDYFLQGGKVLSLCSDILHFVLPNYRTAEVREHELVQFSYDKWQRVKMMHHIFCYQPSPV 579
            :.:||:||||.||.|.|||||:|..:||:.:|||:||.|||.|||.||:::||:|||||||.||.
Mosquito   530 VRKILLDYFLHGGTVFSLCSDLLDIILPDSKTAEIRERELVSFSYRKWKQIKMLHHIFCYQLSPA 594

  Fly   580 KKHFSTDSEESTKSHSRKPALVCPRSMELKDLAGHSHNLDVHVLGTEETWNTPSLMLAKSLQSGG 644
            ||.||.:|||::       .|:....:::.|..|..|:|.|.:|..||||||||::.|.:.::||
Mosquito   595 KKQFSLESEETS-------TLLPVSYVDVSDRQGKPHSLAVEILAQEETWNTPSILEAHNRKTGG 652

  Fly   645 KAVFSQVHLEMNPSEFES--DETKYSILKQNERTRLEIFADLLGKYLDVQVRGGDGVDQPQPGVV 707
            :|:|||:|||::||:|:|  |....|:...|: .|.||.:||||..:.::::..||....:..:|
Mosquito   653 RAIFSQIHLELDPSQFQSNIDGADNSLHSSNQ-LRYEILSDLLGSRIGLKLKEKDGGSADEQSIV 716

  Fly   708 YKHAYFLGRHEAKFELLEKLRLRCSGSDNVIATPNLTMKFCGKDDKPP-VANNNVLPILIHSCPD 771
            ||:|||||:||||.::||.|:...| ..|||....|.::||||.|..| .|.::.||::|..||:
Mosquito   717 YKNAYFLGKHEAKVQMLESLKSTMS-RPNVIQMSELALQFCGKSDAAPHPATDSHLPVMIFHCPE 780

  Fly   772 DFSTVDYFDNLKTEHIGRLVIYAPVVSSSMHLINNLELIHGLAVLPVQQTSGVGRRNNQWLSPPG 836
            |||||:||:||.|..|||:.||||:::|||.:::||.|.||..|:...||.|.||.|||||||||
Mosquito   781 DFSTVEYFENLTTSKIGRIGIYAPIMTSSMQIVSNLTLTHGFMVIARYQTKGKGRNNNQWLSPPG 845

  Fly   837 CAMFSLQLHLTMDSALSSRLPLLQHLVGTAIVNSLRSHEEYGVLDISIKWPNDIYANGNQKIGGL 901
            |||||||||:.|.|.|..|||::||||..|:|:::.|...|..||:.:||||||||.|..|:||.
Mosquito   846 CAMFSLQLHIPMSSMLGQRLPIVQHLVAIAVVSAILSLPGYEKLDLGLKWPNDIYAYGASKLGGS 910

  Fly   902 VINTTLQGSQAIVNIGSGINLNNSRPTVCINDLIREYNTRVPNNKLPILKYELLIAMIFNEIERL 966
            :.||.:...:||||:|.|.||:||:||:|:||:|.:||.: .:..||.|.||...|:|||::|:|
Mosquito   911 IFNTQVDSIEAIVNLGVGFNLSNSKPTLCLNDVIAQYNAK-HSTTLPALSYEKTFALIFNKLEQL 974

  Fly   967 LGEVQNGDFDSFYALYYSLWLHSGQSVKICLQKDQEKEAEIVGIDDFGFLEV-KLPTGTIEIVQP 1030
            ...||....:.....||..|||....:.:...:.:..:..|||||::|||.| |.|:|....|.|
Mosquito   975 YDRVQRDGIEVLQHEYYRYWLHQDAEISMVGTEGESLQGTIVGIDEYGFLLVKKQPSGETVSVHP 1039

  Fly  1031 DGNSFDMLKGLIIPKY 1046
            |||||||::|||:||:
Mosquito  1040 DGNSFDMMQGLIVPKF 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	268..437	CDD:369339	49/190 (26%)
		BPL_N	455..>533	CDD:462915	38/77 (49%)
		BirA2	791..1028	CDD:440109	114/237 (48%)
Hcs	XP_321640.5	None