Protein Alignment Hcs and Hlcs

DIOPT Version :10

• Sequence 1: NP_001287175.1
• Gene: Hcs / 40659
• FlyBaseID: FBgn0037332
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001346974.1
• Gene: Hlcs / 110948
• MGIID: 894646
• Length: 869
• Species: Mus musculus
• Alignment Length: 1100
• Identity: 280/1100 - (25%)
• Similarity: 443/1100 - (40%)
• Gaps: 285/1100 - (25%)

  Fly     1 MLTLYYVSATVLQSWRIQKACSKIAEHLAQPSSIAFYTLQSGSDDGFDPALASSELCCNRNAAKV 65
            ::||.|     |..|         |....:|:::...|::.     ...:..|...|  |.||:.
Mouse     2 LITLCY-----LYLW---------ARWGRRPAALVLSTVRR-----LRASRCSFTFC--RAAAQP 45

  Fly    66 TDI-LWLHANQRGCCLRPLQTL-HITPWISFPPAPSLLPFSYAADTLTPASTPTEADVPRQQRVS 128
            .|. :.|....|..|:...|:: .:..|..|..:|.:|...:.|..       ||         |
Mouse    46 RDARVCLSQGGRVFCVGESQSVDDLNKWALFLVSPFILEAEHIAFV-------TE---------S 94

  Fly   129 LSAQGEERMQLLLEADIEPLQRPSSEDTSAVRLEDYGKLIAWKIDSHLAVLIETDVEHFTKLLIT 193
            :..||..            ||.|||.:|          ::.|
Mouse    95 IWIQGTS------------LQEPSSSET----------VVKW----------------------- 114

  Fly   194 TFLRNNLCINDQLPLLRIESVQREGDPQPFELLAK-HLKRQSRISVGLDKDGWKKHMEDLRAVGV 257
                ::.|    |||     ..|.||  |::|:|| .:...|::.|...:|  :..|::    |:
Mouse   115 ----SDCC----LPL-----ACRPGD--PYQLIAKASVDNFSKLGVAFMED--RLQMDN----GL 158

  Fly   258 LAHQATEFEYQRNRSEGRTKSDPTTHDQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKA--- 319
            :|.:..                 :.|.:.|..:.|.||      ::|....|....|||.:|
Mouse   159 IAQKIV-----------------SVHLKDPALKELGKA------SDKQVQGPPPGPEASPEAQPA 200

  Fly   320 ----------EAKGTSTKPFPTKSDAKPATLAKSEGTPATSKEDSKLTPTKGALKTS------EL 368
                      :.|.....|.|.:....|.:...::|.|..|      :|....|..|      ||
Mouse   201 QGVMEHAGQGDCKAAGEGPSPRRRGCAPESEPAADGDPGLS------SPELCQLHLSICHECLEL 259

  Fly   369 EKLAAVQAAQQQKKEAVQVSPVKAAFLAKPPMLSKHDEPDKASDQPTKPRKSFEAVKPLNSPPSS 433
            |. :.:.:.:....|.:            |.:...|...:.|:.:....||.    |.:|   .|
Mouse   260 EN-STIDSVRSASAENI------------PDLPCDHSGVEGAAGELCPERKG----KRVN---IS 304

  Fly   434 RAAPSRPVLQRNKDSLQDAKPLNVLVYSDSASARESTLATLQQL-------LERNVYTIYPLMPQ 491
            ..||                  |:|:|..|.|  |..|..|||:       ::.:.||:|.|:..
Mouse   305 GKAP------------------NILLYVGSGS--EEALGRLQQVRSVLTDCVDTDSYTLYHLLED 349

  Fly   492 QAAQKYWTEQTALLVVCG--SVAHGIGQILVDYFLQGGKVLSLCSDILHFVLPNYRTA--EVREH 552
            .|.:..|::...|||:..  .:...|....:.|..||||||.|.|.   |.|..:|..  :|..:
Mouse   350 SALRDPWSDNCLLLVIASRDPIPKDIQHKFMAYLSQGGKVLGLSSP---FTLGGFRVTRRDVLRN 411

  Fly   553 ELVQFSYDKWQ----RVKMMHHIFCYQPSPVKKHFSTDSEESTKSHSRKPALVCPRSMELKDLAG 613
            .:....:.|..    |:.::...:.|:..|                            .|..|.|
Mouse   412 TVQNLVFSKADGTEVRLSVLSSGYVYEEGP----------------------------SLGRLQG 448

  Fly   614 HSHNLD-----VHV-LGTEETWNTPSLMLAKSLQSGGKAVFSQVHLEMNP-SEFESDETKYSILK 671
            |..|.|     ||| .||                .||:||..|||||:.| :........:::||
Mouse   449 HLENEDKDKMIVHVPFGT----------------LGGEAVLCQVHLELPPGASLVQTADDFNVLK 497

  Fly   672 QNERTRLEIFADLLGKYLDVQVRGGDGVDQPQPGVVYKHAYFLGRHEAKFELLEKLRLRCSGSDN 736
            .:...|.|:..::|...       |...|.||...:......|...|.:...::.|. |.:..:.
Mouse   498 SSNVRRHEVLKEILTAL-------GLSCDAPQVPALTPLYLLLAAEETQDPFMQWLG-RHTDPEG 554

  Fly   737 VIATPNLTMKFCGKDDKPPVANNNVLPILIHS---CPDDFSTVDYFDNLKTEHIGRLVIYAPVVS 798
            :|.:..|:::|............:.:|::...   ..:.||...|..||:|..:|:::::|.|.|
Mouse   555 IIKSSKLSLQFVSSYTSEAEITPSSMPVVTDPEAFSSEHFSLETYRQNLQTTRLGKVILFAEVTS 619

  Fly   799 SSMHLINNL------ELIHGLAVLPVQQTSGVGRRNNQWLSPPGCAMFSLQLHLTMDSALSSRLP 857
            ::|.|::.|      |:  ||..:.|:||.|.||..|.||||.|||:.:|.:.:.:.|.|..|:|
Mouse   620 TTMSLLDGLMFEMPQEM--GLIAIAVRQTQGKGRGPNAWLSPVGCALSTLLVFIPLRSQLGQRIP 682

  Fly   858 LLQHLVGTAIVNSLRSHEEYGVLDISIKWPNDIYANGNQKIGGLVINTTLQGSQAIVNIGSGINL 922
            .:|||:..|:|.::||...|..:::.:|||||||.:...||||:::|:||.|....:.||.|.|:
Mouse   683 FVQHLMSLAVVEAVRSIPGYEDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNV 747

  Fly   923 NNSRPTVCINDLIREYNTRVPNNKLPILKYELLIAMIFNEIERLLGEVQNGDFDSFYALYYSLWL 987
            .||.||:||||||.|:|.:......| |:.:.|||.....:|:|:...|:...|....|||..|:
Mouse   748 TNSNPTICINDLIEEHNKQHGAGLKP-LRADCLIARAVTVLEKLIDRFQDQGPDGVLPLYYKYWV 811

  Fly   988 HSGQSVKICLQKDQEKEAEIVGIDDFGFLEVKLPTGTIEIVQPDGNSFDMLKGLIIPKYQ 1047
            |.||.|:  |...:..:|.|||:||.|||:|....|.:..|.|||||||||:.||:||.|
Mouse   812 HGGQQVR--LGSTEGPQASIVGLDDSGFLQVHQEDGGVVTVHPDGNSFDMLRNLIVPKRQ 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	268..437	CDD:369339	33/187 (18%)
		BPL_N	455..>533	CDD:462915	27/86 (31%)
		BirA2	791..1028	CDD:440109	96/242 (40%)
Hlcs	NP_001346974.1	BPL_N	309..531	CDD:462915	67/277 (24%)
		BPL	610..790	CDD:319741	73/182 (40%)
		BPL_C	812..859	CDD:426672	23/48 (48%)