DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcs and hlcs

DIOPT Version :9

Sequence 1:	NP_001287175.1	Gene:	Hcs / 40659	FlyBaseID:	FBgn0037332	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_004912172.1	Gene:	hlcs / 100492512	XenbaseID:	XB-GENE-1009304	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	981	Identity:	256/981 - (26%)
Similarity:	411/981 - (41%)	Gaps:	238/981 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 PRQQRVSLSA-------QGEE------RMQLLLE----ADI----------------EPLQRPSS 153
            |::.:.||..       :|.:      :..||||    :|:                |.|...|:
Frog    53 PKEDKFSLKVGRKLFLIEGSQLFEDLNKWNLLLESPRDSDLGKGQITFITESVSLPSETLSASSN 117

  Fly   154 EDTSAVRLEDYGKLIAWKIDSHLAVLIETDVEHFTKLLITTFLRNNLCINDQLPLLRIESVQREG 218
            ......:|.:|..|:|...:....:|.|..||.|::|.| .|:.:.|.:::..||.:|.||
Frog   118 SSKKVQKLSEYCLLLARYHEDPCKLLAEASVEDFSELGI-AFMEDRLLMDNGSPLHKITSV---- 177

  Fly   219 DPQPFELLAKHLKRQSRISVGLDKDGWKKHMEDLRAVGVLAHQATEFEYQRNRSEGRTKSDPTTH 283
                      :||..:                       |..|.||   :.|....:::::|
Frog   178 ----------YLKESA-----------------------LKAQETE---ETNLRTSKSRTEP--- 203

  Fly   284 DQRPTSELLAKAVAVVEPTNKAYLSPARTTEASLKAEAKGTSTKPFPTKSDAKPATLAKSEGTPA 348
                                  :|:|      |:..|..||                  :|.:.|
Frog   204 ----------------------HLAP------SVGQENMGT------------------AESSAA 222

  Fly   349 TSKEDSKLTPTKGALKTSELE-----KLAAVQAAQQQKKEAVQVSPVKAAFLAKPPMLSKHDEPD 408
            |.|.:             |||     .|::.....:.:...::  .|:.|        |:.:.||
Frog   223 TDKGE-------------ELEAHRHLHLSSCHECLELENRTIE--SVRCA--------SEENIPD 264

  Fly   409 KASDQPTKPRKSFEAVKPLNSPPSSRAAPSRPVLQRNKDSLQ-DAKPLNVLVY--SDSASAREST 470
            ...|              .:|...|..        :|..||. ..||.|||:|  .::....:..
Frog   265 LPED--------------FSSLEGSEL--------QNHGSLNVSGKPPNVLIYCGPETGGQFQEI 307

  Fly   471 LATLQQLLERNVYTIYPLMPQQAAQKYWTEQTALLVVCGS--VAHGIGQILVDYFLQGGKVLSLC 533
            .:.|.|..:.:.|.||||...|..:..||:...||||...  |::.|.:..:.|..:|||:|.|.
Frog   308 KSVLLQCFDSSRYVIYPLPDDQVLKAPWTDNCLLLVVASDHPVSNHIEEQFLSYLSKGGKILGLS 372

  Fly   534 SDILHFVLPNYRTAEVREHELVQFSYDKWQRVKMMHHIFCYQPS--PVKKHFSTDSEESTKSHSR 596
            |. ..|.   :.:..|.....:|.|         :..:...:|:  ||    |.|...|.|..:.
Frog   373 SS-SSFA---FGSVSVTSKSQLQGS---------VQALVFGRPNCDPV----SLDLVASGKVFAE 420

  Fly   597 KPALVCPRSMELKDLAGHSHNLDVHVLGTEETWNTPSLMLAKSLQSGGKAVFSQVHLEMNPSEFE 661
            ..:...|:....    |:.:|.|..::...:|:.          .:||:||..||.||.:|....
Frog   421 LSSEASPQVSGW----GYLNNDDKDLILVHQTYG----------DNGGEAVLCQVKLEASPESVS 471

  Fly   662 SDET-KYSILKQNERTRLEIFADLLGKYLDVQVRGGDGVDQPQPGVVYKHAYFLGRHEAKF-ELL 724
            .|:| .:..||::...|..:...:|       :..|...|...|..: ...|.|...:..: ::|
Frog   472 EDDTGTFESLKKSNPLRYAVLTQIL-------ISLGLDCDLASPPAL-TPVYLLTAEQTCYDDVL 528

  Fly   725 EKLRLRCSGSDNVIATPNLTMKFCGKDDKPPVANNNVLPILI-----HSCPDDFSTVDYFDNLKT 784
            ..|:.| :.|..:|.:..:::|.| ...:|.:..:..|..|:     .:| ::||...|.::|.|
Frog   529 HWLKTR-TDSGGLIKSGKMSLKVC-PSPQPDIDVSPTLSPLVTQPESFTC-EEFSVERYSESLCT 590

  Fly   785 EHIGRLVIYAPVVSSSMHLINNLELIH-----GLAVLPVQQTSGVGRRNNQWLSPPGCAMFSLQL 844
            :.:|::|::|.|.:::.:|:..| :.|     ||..:...||.|.||..|.||||.|||:.:|.:
Frog   591 DKLGKIVLFAEVTTTTFNLLEGL-MFHEPKEMGLIAIAAHQTQGKGRGGNAWLSPKGCALMTLHI 654

  Fly   845 HLTMDSALSSRLPLLQHLVGTAIVNSLRSHEEYGVLDISIKWPNDIYANGNQKIGGLVINTTLQG 909
            .:.:.|.|..|:..:|||:..|:|.|:||...|..:|:.:|||||||.....||||:::|:||.|
Frog   655 SIPLLSELGQRIAFVQHLMSLAVVESVRSLPGYEDIDLRVKWPNDIYYGDLMKIGGVLVNSTLMG 719

  Fly   910 SQAIVNIGSGINLNNSRPTVCINDLIREYNTRVPNNKLPILKYELLIAMIFNEIERLLGEVQNGD 974
            :...:.||.|.|::||.|||||||||.::|.....|..| |:.:.|||.....:|.|:...|:..
Frog   720 NTFHILIGCGFNVSNSNPTVCINDLIAQHNKTYKTNIEP-LRVDTLIARAVTALEGLIKAFQSKG 783

  Fly   975 FDSFYALYYSLWLHSGQSVKICLQKDQEKEAEIVGIDDFGFLEVKLPTGTIEIVQPDGNSFDMLK 1039
            .|.....||..|||||  .|:.|..|....|.|:|:||.|||:|......|..|.|||||||||:
Frog   784 PDGVLPAYYKYWLHSG--AKVRLGGDDGPLAWIIGVDDSGFLQVLQEGKEIVSVHPDGNSFDMLR 846

  Fly  1040 GLIIPK 1045
            .|||||
Frog   847 NLIIPK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcs	NP_001287175.1	HC2	293..437	CDD:284736	22/148 (15%)
		GAT_1	456..>509	CDD:294025	18/54 (33%)
		BPL_LplA_LipB	793..921	CDD:301309	52/132 (39%)
		BirA2	812..1037	CDD:223417	97/224 (43%)
		BPL_C	988..1037	CDD:280411	23/48 (48%)
hlcs	XP_004912172.1	BPL	595..773	CDD:319741	72/179 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3121
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392751at2759
OrthoFinder	1	1.000	-	-		FOG0003219
OrthoInspector	1	1.000	-	-		oto105079
Panther	1	1.100	-	-	LDO	PTHR12835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R144
SonicParanoid	1	1.000	-	-		X2178
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100