DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POLDIP2 and FBXO3

DIOPT Version :9

Sequence 1:	NP_730934.1	Gene:	POLDIP2 / 40655	FlyBaseID:	FBgn0037329	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	XP_011518282.1	Gene:	FBXO3 / 26273	HGNCID:	13582	Length:	479	Species:	Homo sapiens

Alignment Length:	226	Identity:	63/226 - (27%)
Similarity:	98/226 - (43%)	Gaps:	38/226 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 GNQDSNRSLYAIPGLDYVAHEDIMPYSSSE------KSPLQHELFDKFLTHAPDADPPFVGQDTL 269
            |.|......|.:| |.:..|..:..|.:.|      |:.:.::..|: :...|.|...|:...|.
Human   183 GFQQRQGLKYCLP-LTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQ-MARNPAAIDMFIIGATF 245

  Fly   270 KAW---QEKN-----HPWLD---MSDVHK----ETTENVRITVIPFYMGCRETPASSV----YWW 315
            ..|   ..||     .|.:.   ...||.    .||.::.::|...::    ...|||    |::
Human   246 TDWFTSYVKNVVSGGFPIIRDQIFRYVHDPECVATTGDITVSVSTSFL----PELSSVHPPHYFF 306

  Fly   316 RYCIRLE----NLGELSVQLRERHWRIFSLSGTLETVRGRGVVGQEPILSPRLPAFQYSSHVSLQ 376
            .|.||:|    .|.|.:.||..|:|||.:..|.:|.|:|.||||:.||:||. ..::|:|..:..
Human   307 TYRIRIEMSKDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPG-RVYEYTSCTTFS 370

  Fly   377 APSGHMWG--TFRLEREDGYSFDCKIPPFSL 405
            ..||:|.|  ||.........|:..||.|.:
Human   371 TTSGYMEGYYTFHFLYFKDKIFNVAIPRFHM 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POLDIP2	NP_730934.1	YccV-like	72..258	CDD:294919	10/52 (19%)
POLDIP2	NP_730934.1	DUF525	308..390	CDD:282262	36/91 (40%)
FBXO3	XP_011518282.1	F-box-like	13..57	CDD:289689
		SMI1_KNR4	121..249	CDD:286436	14/67 (21%)
		DUF525	294..383	CDD:282262	35/89 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2967
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810