DRSC/TRiP Functional Genomics Resources

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Protein Alignment PEK and EIF2AK3

DIOPT Version :9

Sequence 1:NP_649538.1 Gene:PEK / 40653 FlyBaseID:FBgn0037327 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_004827.4 Gene:EIF2AK3 / 9451 HGNCID:3255 Length:1116 Species:Homo sapiens


Alignment Length:1217 Identity:399/1217 - (32%)
Similarity:582/1217 - (47%) Gaps:258/1217 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 AGLVAFDPAQVLAGHPTTDSEL--QTAGSPRPPGLEHCVDQEERRVARRLLYISTLDGRLSALDI 89
            ||.||  .|:|    ...|:|.  ..||...|.|.|...:.|.|...|.|:.|||||||::|||.
Human    62 AGAVA--AAEV----TVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP 120

  Fly    90 AKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIYKFDGD--SIDPIPITAEHLL 152
            ...||.:|.:..|.|.|:|||:.:.|:..|..   :||||.|.::::|.|  |::.:|.|.|.||
Human   121 ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKM---IIPSLDGALFQWDQDRESMETVPFTVESLL 182

  Fly   153 SSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDG 217
            .||.||.||:|:.|||...:||:|..:|::.|.||..||              |:.| .|::|..
Human   183 ESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGC--------------RQWD-SDEMEQE 232

  Fly   218 EQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLV----------- 271
            |                 |:::::|..:|||||..|:|.|:||||||..||..:           
Human   233 E-----------------DILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIE 280

  Fly   272 ---RPSECQLQPR-----DELELAVLDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWN 328
               :|:|...:.:     :|.|.|::|:.|||.|.:..:.||||.... :.|:|:|..||.|||.
Human   281 STFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGH-LEWEYQFCTPIASAWL 344

  Fly   329 TNADDELQPIDLFSSAQWLWDQD--ENDTELPNAPQ--SPPSIYLGMYDKQLYIQESIRLRQEIM 389
            .. |.::.||.||....:..:.|  |::.::..|.:  :..|:|||||..|||:|.|:|:.::..
Human   345 LK-DGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFP 408

  Fly   390 DQTKVYQQLTGDTSL--MPRIPWKP-ISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDEN 451
            ...|..:.:|.:.::  :|.|.||| |.:.|::.|:...|:.|..:..:          .:..|.
Human   409 SSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSND----------KFSHEE 463

  Fly   452 FAVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGN 516
            ::..|.|:|   ::...||:|.                          |..........|:.|..
Human   464 YSNGALSIL---QYPYDNGYYL--------------------------PYYKRERNKRSTQITVR 499

  Fly   517 HSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVV-----IAFTSAVILNIFMGQ-RNQRVEREYL 575
            ...|.....::...| ||     .|..||||||.     |..|:.::..:|... ..||.|.|  
Human   500 FLDNPHYNKNIRKKD-PV-----LLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESE-- 556

  Fly   576 VIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQS 640
                          |:..|:             |::....|:||..:.:: ..:||  |.||:.:
Human   557 --------------TQCQTE-------------NKYDSVSGEANDSSWND-IKNSG--YISRYLT 591

  Fly   641 DFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFH 705
            |||.:|||||||||||||||||:|:..||||||.|||:|.:|::|:||.:.||..||..|||||:
Human   592 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFN 656

  Fly   706 SWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLLS--WVSDAANST 768
            :|.|.||..|||:.|...|..| ||...:.:|.....||    :|.:|.....:  .:...|.|.
Human   657 AWLEAPPEKWQEKMDEIWLKDE-STDWPLSSPSPMDAPS----VKIRRMDPFATKEHIEIIAPSP 716

  Fly   769 ACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFR-------SESQSAALRAEEEDDTDDDYEEDE 826
            ..|..|.: |.|.     ::....|.:.|.:||.       |||..||...::...||.|. ||.
Human   717 QRSRSFSV-GISC-----DQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDV-EDG 774

  Fly   827 EQQGDHE----------------KRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQI------- 868
            ...|:.|                .|.|:|.||....:..|..:   |:.:..:|...|       
Human   775 TMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNAS---SKEEPKTNRLHIGNHCANK 836

  Fly   869 -ESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQ 932
             .:.:|.||.|......:.:..:|.||:|....|..:.....:|              |||||||
Human   837 LTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSP--------------KVYLYIQ 887

  Fly   933 MQLCRKESLRDWLR-----DNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDG 992
            |||||||:|:||:.     :.|..:...|   ||.||.:||:::|.|||:|||||||||||:.|.
Human   888 MQLCRKENLKDWMNGRCTIEERERSVCLH---IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD 949

  Fly   993 QIKIGDFGLVTDMADIPNLVAKCGDQ--------SGLPSCARHTQQVGTHLYMSPEQLLGQHYDY 1049
            .:|:|||||||.|           ||        :.:|:.||||.||||.|||||||:.|..|.:
Human   950 VVKVGDFGLVTAM-----------DQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003

  Fly  1050 KVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQT 1114
            ||||:|||||.|||...|||:|||::||..:|:.::|..|...||.:|.::|.|||..|.:||:.
Human  1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEA 1068

  Fly  1115 KQLKSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSSEPH 1161
                         .:::.....|..:...:.....|||:.|||...|
Human  1069 -------------INIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKH 1102

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PEKNP_649538.1 Luminal_EIF2AK3 73..401 CDD:188874 121/352 (34%)
PKc_like 635..1113 CDD:304357 206/523 (39%)
S_TKc <925..1118 CDD:214567 103/205 (50%)
EIF2AK3NP_004827.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..101 7/23 (30%)
Luminal_EIF2AK3 104..420 CDD:188874 121/352 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..571 7/49 (14%)
PKc_like 587..>663 CDD:304357 48/75 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..863 5/21 (24%)
STKc_EIF2AK3_PERK <873..1075 CDD:270950 104/242 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1090..1116 7/13 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 203 1.000 Domainoid score I2973
eggNOG 1 0.900 - - E1_KOG1033
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 497 1.000 Inparanoid score I1394
Isobase 1 0.950 - 0 Normalized mean entropy S5352
OMA 1 1.010 - - QHG49379
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 1 1.000 - - FOG0005413
OrthoInspector 1 1.000 - - oto91797
orthoMCL 1 0.900 - - OOG6_106778
Panther 1 1.100 - - O PTHR11042
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4549
SonicParanoid 1 1.000 - - X3837
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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