DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PEK and eif2ak1

DIOPT Version :9

Sequence 1:	NP_649538.1	Gene:	PEK / 40653	FlyBaseID:	FBgn0037327	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001039038.1	Gene:	eif2ak1 / 733794	XenbaseID:	XB-GENE-962479	Length:	631	Species:	Xenopus tropicalis

Alignment Length:	594	Identity:	174/594 - (29%)
Similarity:	255/594 - (42%)	Gaps:	170/594 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 ISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR---QR 684
            ||.:.....|..|||:.::|:.:..||:||:|.|::.:||||...||||:|.:  |:.||   ::
Frog   147 ISRAKKMLSETQTSRYLNEFDEIAQLGKGGYGKVYKVRNKLDGQFYAIKKILI--KKVSRRDCRK 209

  Fly   685 VLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQL 749
            ||||.:.||..:|.|||.|..:|.|                       .::.|:.
Frog   210 VLREVKVLAGLQHPNIVGYHTAWME-----------------------HVQPPNS---------- 241

  Fly   750 KEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEE 814
                |.:||..|..:.|:.|         |..:|.:|..    |...|.|.|
Frog   242 ----QCKLLKAVKGSPNNKA---------EQDMKEVRSV----ESSGSFIMF------------- 276

  Fly   815 EDDTDDDYEEDEEQQGDHEKRHRSSVSID-----IHSASFDLK---NINYSQH-QLVSNSFQIES 870
                :|...:|...|...|..:.|..|.|     |.:|..:.|   |.|.::. :..|.|:|.:.
Frog   277 ----EDSAHQDPSAQSVSESVNMSVSSPDKPDHCIENAGNNYKKDSNANVAKKTKACSKSYQSQG 337

  Fly   871 V------RPKSSGSD----DANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPS 925
            :      .|.||..|    |::.|.:..:|.|.|   ..|...|                    .
Frog   338 LVCQRDKCPFSSEDDVDKSDSSCDEECPQKDLCL---HRHFEIQ--------------------Y 379

  Fly   926 KVYLYIQMQLCRKESLRDWL--RDN----------------RSETRAAHIGDIFHQIVDAVDYVH 972
            .:.|:|||:||.| ||.||:  |:|                |..||      |.:||::.|.|:|
Frog   380 HLMLHIQMKLCEK-SLWDWIVERNNHFQESGNSNPYDFVDVRITTR------ILYQILEGVRYIH 437

  Fly   973 LKGLIHRDLKPSNIFF-SQDGQIKIGDFGLVTDMADIPNLVAKCGD----------QSGLPSCAR 1026
            ...::||||||.|:|. ..|..::||||||.            |.|          |....:...
Frog   438 SMEVLHRDLKPRNVFLHGADLHVRIGDFGLA------------CRDIFQQSRDSWLQKDRSNGLT 490

  Fly  1027 HTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAV 1091
            ||..|||.||.:||||.|.|||:|.|:||:|:|..||...|.|||||.:.|.:||:|..|..:..
Frog   491 HTTGVGTCLYAAPEQLKGSHYDFKSDMYSIGIILLELFQPFGTEMERTQVLTALRNGTVPCSYER 555

  Fly  1092 NYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQLRNILQLPHLLSEGQSEQAELAERARRLSRS---- 1151
            .:|.|.:.::.:.|::..:||...| |:|||.:  |..:|:.:.|.:...|.|...||.||
Frog   556 QWPVQSNFVKLLTSSECSERPSASQMLESQLFH--QKENLVQDLQKKVLYLEEENERLKRSLQKL 618

  Fly  1152 -RTFSSSSE 1159
             ..||.:.|
Frog   619 QEQFSGTEE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	153/528 (29%)
		S_TKc	<925..1118	CDD:214567	80/222 (36%)
eif2ak1	NP_001039038.1	STKc_EIF2AK1_HRI	159..585	CDD:270951	156/536 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010