DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PEK and EIF2AK2

DIOPT Version :9

Sequence 1:	NP_649538.1	Gene:	PEK / 40653	FlyBaseID:	FBgn0037327	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001129123.1	Gene:	EIF2AK2 / 5610	HGNCID:	9437	Length:	551	Species:	Homo sapiens

Alignment Length:	692	Identity:	152/692 - (21%)
Similarity:	225/692 - (32%)	Gaps:	311/692 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 QEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNP 491
            ||..::.|:.|..|             :.::.....|::::...  |.||        |.:|:|
Human   151 QEAKQLAAKLAYLQ-------------ILSEETSVKSDYLSSGS--FATT--------CESQSN- 191

  Fly   492 TDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTSA 556
                ::...|..:.::|||..:.....:|.    :.|.::                      :|:
Human   192 ----SLVTSTLASESSSEGDFSADTSEINS----NSDSLN----------------------SSS 226

  Fly   557 VILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQR 621
            :::|   |.||                      .:...:..|.|         ||..|..:..:.
Human   227 LLMN---GLRN----------------------NQRKAKRSLAP---------RFDLPDMKETKY 257

  Fly   622 TISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVL 686
            |:.:           ||..||:.::.:|.||||.||:||:::|...|.|||:...|:::.
Human   258 TVDK-----------RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE----- 306

  Fly   687 REARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKE 751
            ||.:.||..:|.|||.|...|
Human   307 REVKALAKLDHVNIVHYNGCW-------------------------------------------- 327

  Fly   752 KRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEED 816
                                               :.:|||.|
Human   328 -----------------------------------DGFDYDPE---------------------- 335

  Fly   817 DTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDA 881
             |.||..|                                                  ||..|..
Human   336 -TSDDSLE--------------------------------------------------SSDYDPE 349

  Fly   882 NDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLR 946
            |..|.:|.|...                                   |:|||:.|.|.:|..|:.
Human   350 NSKNSSRSKTKC-----------------------------------LFIQMEFCDKGTLEQWIE 379

  Fly   947 DNRSETRAAHIG-DIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPN 1010
            ..|.|.....:. ::|.||...|||:|.|.||||||||||||.....|:|||||||||
Human   380 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT------- 437

  Fly  1011 LVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIK 1075
                     .|.:..:.|:..||..||||||:..|.|..:||:|:||||..||.....|..|..|
Human   438 ---------SLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSK 493

  Fly  1076 TLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQL 1117
            ....||||.....|.   .::..|||::||.:||.||.|.::
Human   494 FFTDLRDGIISDIFD---KKEKTLLQKLLSKKPEDRPNTSEI 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	121/478 (25%)
		S_TKc	<925..1118	CDD:214567	79/194 (41%)
EIF2AK2	NP_001129123.1	(Microbial infection) Interaction with HCV NS5A. /evidence=ECO:0000269\|PubMed:17267064	2..180		6/41 (15%)
		DSRM	14..>59	CDD:214634
		DSRM	101..166	CDD:214634	5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		5/23 (22%)
		STKc_EIF2AK2_PKR	260..536	CDD:270949	123/495 (25%)
		Interaction with TRAF5. /evidence=ECO:0000269\|PubMed:15121867	266..551		121/478 (25%)
		2 X 13 AA approximate repeats	331..357		13/98 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4549
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950