Protein Alignment PEK and eif2ak3

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_005156642.2
• Gene: eif2ak3 / 559564
• ZFINID: ZDB-GENE-050414-2
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1217
• Identity: 373/1217 - (30%)
• Similarity: 545/1217 - (44%)
• Gaps: 317/1217 - (26%)

  Fly    50 TAGSPRPPGLEHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRL 114
            |..|..|.|   ..|....:..|.|:.|||||||::|||....|:.:|.:..|.|.|:|||:.:.
Zfish    80 TGDSDEPSG---DTDANFHKHRRALVIISTLDGRIAALDPLNQGRKQWDLDVGSGCLVSSSLSKP 141

  Fly   115 ELTNNGQFVRMIPSLSGGIYKF--DGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSV 177
            |:..|..|   ||||.|.::::  |.:|::.:..:.|.||.||.:..:|.|:.|||...:||:..
Zfish   142 EIFGNKMF---IPSLDGALFQWNRDRESMEAVSFSVESLLDSSYRIGEDTVLVGGKSLTTYGLGA 203

  Fly   178 RTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRR 242
            .:|:|.|.||..||             .|..|||.:.|                    ||::::|
Zfish   204 YSGKLKYICSAVGC-------------SRWGDEEGEPE--------------------DVLLLQR 235

  Fly   243 QTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQL--------------QPRDELELAV----- 288
            ..:|||||..|.|.|:||||||..||..|...:.:|              :.|.|.:..:
Zfish   236 TQKTVRAVRPRNGFEKWNFSVGNFELKFVPEVQSKLNFLEGEAPSGETWREVRREAQRVIQEETD 300

  Fly   289 --------------------LDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADD 333
                                ||:.|||.||:..:.|||......::|:::|..||.|||.... .
Zfish   301 AQTKNHAKMHPNSAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQFCTPIASAWLVGG-G 364

  Fly   334 ELQPIDLFSSAQWLWDQDENDT--------ELPNAPQSPPSIYLGMYDKQLYIQESIRLRQEIMD 390
            ::.||.||....:. .|.|.:|        |...|.:|  |:||||:..|||:|.|:|:.::...
Zfish   365 KVTPISLFDDTSYN-SQTETETQEDDDIMEEARGATES--SVYLGMFQGQLYLQSSVRISEKFPS 426

  Fly   391 QTKVYQQLTGDTSLM--PRIPWKP-ISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENF 452
            ::|......|||.:|  |.:.||| |.:.|::.|:...::.|..:..:          .:..|.:
Zfish   427 KSKALNGWGGDTDMMPPPTVKWKPLIHSPSRTPVLVGSEEFDKCLNND----------KFSHEEY 481

  Fly   453 AVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNH 517
            :..|.|:|   ::...||:||                          |.||.........|....
Zfish   482 SNGALSIL---QYPYDNGYYF--------------------------PYSPRYRNRRDETAVSVL 517

  Fly   518 SVNDDLGFSLDDIDAPVKVVILSLWFWWKEIV-----VIAFTSAVILNIFMGQRNQRVEREYLVI 577
            ...|..|..:...|   .|::|.   |||||:     .||.|:.::...|
Zfish   518 LKKDGEGSQVRRKD---PVLLLP---WWKEILGTIFFCIAATTYIVRKFF--------------- 561

  Fly   578 ERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDF 642
              |.|...:.:..|:.||.         :...:|.....:..:..:::....   .|.||:.:||
Zfish   562 --HPPTTYSRQRKESETQC---------QTDTKFEADVTEPKEVVVTDMRPC---EYVSRYLTDF 612

  Fly   643 ELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSW 707
            |.:||||||||||||||:||:|:..||||||.|||:|.:|::|:||.:.||..||..|:|||::|
Zfish   613 EPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIIRYFNAW 677

  Fly   708 TETPPTGWQEEEDRKLL---------------AHELSTSIQIETP---DDSTMPSLTEQLKEKRQ 754
            .|:||.||||:.|::.|               ....|..:.:.||   |.|.|
Zfish   678 QESPPQGWQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDSSCM------------ 730

  Fly   755 QQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTD 819
                  .:...:::.|..|..........::..|.|...:.|:::|......|..|...
Zfish   731 ------CAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSDSPHSFELCPP------ 783

  Fly   820 DDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLK-NINYSQHQ----LVSNSFQIESVRPKSSGSD 879
                             |:....|..|:|||:. ..:..:||    .:|.|..:..|....|||
Zfish   784 -----------------RTVAHGDCTSSSFDIVFEDSGCEHQDNDSDLSGSTPVPPVCLSQSGS- 830

  Fly   880 DANDDNKARR------------KPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQ 932
                  |.:|            :|.||:||.        |.|.|:...:|.      .|||||||
Zfish   831 ------KPQRSTSTGPPISLPSRPTTLSLAP--------STPCPAVRPLLT------PKVYLYIQ 875

  Fly   933 MQLCRKESLRDW-----LRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDG 992
            |||||||:|:||     |.:.|..|:..   |||.||.:|||::|.|||:|||||||||||:.|.
Zfish   876 MQLCRKENLKDWMAQRCLPELREHTQCL---DIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDD 937

  Fly   993 QIKIGDFGLVTDMADIPNLVAKCGDQ----------SGLPSCARHTQQVGTHLYMSPEQLLGQHY 1047
            .:|:|||||||.|           ||          :.:|..||||.||||.||||||||.|..|
Zfish   938 VVKVGDFGLVTAM-----------DQEEDDEELSTLTPMPIYARHTGQVGTKLYMSPEQLSGNSY 991

  Fly  1048 DYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRP 1112
            .:||||||||||.|||...|.|:|||::||..:|..|:|..|......:..:::.|||..|.:||
Zfish   992 SHKVDIYSLGLILFELLCPFRTQMERVRTLTEVRALQFPAAFCKANILEAQMVRCMLSRVPAERP 1056

  Fly  1113 QTKQL-KSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSS 1158
            :..:: ::.|...|::|                .|...|:||:|:||
Zfish  1057 EASEITEAPLFQELEVP----------------CRIRQRTRTYSASS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	115/376 (31%)
		PKc_like	635..1113	CDD:304357	196/527 (37%)
		S_TKc	<925..1118	CDD:214567	104/208 (50%)
eif2ak3	XP_005156642.2	Luminal_EIF2AK3	100..437	CDD:188874	115/376 (31%)
		STKc_EIF2AK3_PERK	606..1063	CDD:270950	197/532 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3243
eggNOG	1	0.900	-	-		E1_KOG1033
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	457	1.000	Inparanoid score	I1557
OMA	1	1.010	-	-		QHG49379
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	1	1.000	-	-		FOG0005413
OrthoInspector	1	1.000	-	-		otm25315
orthoMCL	1	0.900	-	-		OOG6_106778
Panther	1	1.100	-	-	O	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4549
SonicParanoid	1	1.000	-	-		X3837
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870