Protein Alignment PEK and Gcn2

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 254/1173 - (21%)
• Similarity: 415/1173 - (35%)
• Gaps: 412/1173 - (35%)

  Fly   113 RLELTNNGQFVRMIPSLSGGIYKFDGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSV 177
            :|.:|...::.::.|.:|                     |..|...||.|:.:...:.::....:
  Fly    67 KLHVTCPSKYPKLPPKIS---------------------LEESKGMSDQLLEALRNQLQAQSQEL 110

  Fly   178 RTGQLLYECSLNGCV-----NSTEEGLAIDDTIREPDEEDQ-LEDGEQLRDEAGYIVRHDPLLDD 236
            |...::||.:.....     |...:|...|..:::..:.|| |:|.::.|:.    ::...|:|:
  Fly   111 RGEVMIYELAQTVQAFLLEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRES----LQRQTLIDE 171

  Fly   237 VIIVRRQTQTVRAVESRTGVERWNFSVG--QHELDL-------------VRPSECQLQPRDELEL 286
               |.|:.:..:....|.|..|.:.|..  :|....             :.||:| |..|:...|
  Fly   172 ---VERRKEMFKTEAKRRGEPRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKC-LDHRNTETL 232

  Fly   287 AVLDVDIKVVVPEGIICAFSKSEPQ--------------TMLWKYKFDHPIVSAWNTNADDELQP 337
            ....:..:  :..|  |...:...|              .:|:        ::.||.......||
  Fly   233 YFHKMGRQ--IQRG--CCVGEGHSQRGCIAYTGIDMHCGQLLY--------ITEWNIKYSQLEQP 285

  Fly   338 IDLFSSAQWLWDQDEN-------DTELPNAPQSPPSI------YLGMYDKQLYIQES----IRLR 385
              .....:..|..:..       |..:.:..:...|:      .|..|:..|.|:..    :.|.
  Fly   286 --CIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLV 348

  Fly   386 QEIMDQTKVYQQLTGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDE 450
            |:.:..|.|:       |:...:.|                      ..:||
  Fly   349 QDFLLGTSVF-------SISSSLGW----------------------CMDGA------------- 371

  Fly   451 NFAVAAQSVLNASEFVNGNG----------FYFYTTGD---------------LNGPQECSTQNN 490
              .:.|:.||:|..|::..|          .:...||:               |:|..:.|:..
  Fly   372 --RMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPNLLELLSGAGQSSSCG- 433

  Fly   491 PTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTS 555
              ||||:       .|..|....|.::.:.|.:.....|                :.:.......
  Fly   434 --DLPAL-------GALVESLMPTNSYEMRDFVDKCNSD----------------RTLSASELLE 473

  Fly   556 AVILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQ 620
            ...|..::....|:|          :|:.   :....:|....|..:|.|.|
  Fly   474 HPFLRFYVDNGQQQV----------MPLP---QQQHPNTVQRTGSAMPYQIP------------- 512

  Fly   621 RTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQ-- 683
             |::.|        .||.:::||::..||:|.||.|.:.:|.||...||||||.||.:  |||
  Fly   513 -TLALS--------QSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPAR--SRQLY 566

  Fly   684 -RVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTE 747
             ::.||...|:...|.|:||||:||.|:.......|.| |||..|.|.|.|    |.|..|:.:.
  Fly   567 KKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMD-KLLGGEWSQSQQ----DLSVKPAKSP 626

  Fly   748 QLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRA 812
            ||....::.     .|..:|::...:.::|...           |.:.|. |||...:...|:
  Fly   627 QLGPTLEED-----EDEEDSSSSMWNGYIPNME-----------DSDSDG-IEFVDSNGKVAV-- 672

  Fly   813 EEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSG 877
                      .:||||:                                       :|.|.|::.
  Fly   673 ----------YDDEEQE---------------------------------------DSTRGKTNS 688

  Fly   878 SDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLR 942
                                                        .||....:||||:.|.|.:||
  Fly   689 --------------------------------------------PKPLMQVMYIQMEFCEKCTLR 709

  Fly   943 DWLRDNR-SETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVT--- 1003
            ..:.||. ::|  ..:..:|.:|.:.:.::|.:|:|||||||.|||.....|||||||||.|
  Fly   710 TAIDDNLFNDT--DRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSF 772

  Fly  1004 ------DMADIP-NLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQH----YDYKVDIYSLG 1057
                  |.|..| |.:....|.:|       |.:|||.||::|| |.|..    |:.|||:|:||
  Fly   773 LALQAHDAAPAPVNQITSAEDGTG-------TGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLG 829

  Fly  1058 LIFFEL-HVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ------QYD----LLQQMLSAQPEQR 1111
            :|.||: ...|.|.|||.:|:.:||      :.::|.|.      :|:    :||.:|:..|.||
  Fly   830 IILFEMCQPPFDTSMERAQTIMALR------NVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQR 888

  Fly  1112 PQTKQL-------KSQLR-NILQ--LPHLLSEGQS-------------EQAELAERARRLSRSRT 1153
            |..::|       .:||. |.||  |.|.|:..||             |..|:.|....|..||.
  Fly   889 PTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRA 953

  Fly  1154 FSS 1156
            ..|
  Fly   954 MKS 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	54/339 (16%)
		PKc_like	635..1113	CDD:304357	146/506 (29%)
		S_TKc	<925..1118	CDD:214567	80/225 (36%)
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735	12/83 (14%)
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	40/294 (14%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	148/514 (29%)
		S_TKc	525..895	CDD:214567	145/504 (29%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26425at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950