DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PEK and Myt1

DIOPT Version :9

Sequence 1:	NP_649538.1	Gene:	PEK / 40653	FlyBaseID:	FBgn0037327	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	92/395 - (23%)
Similarity:	151/395 - (38%)	Gaps:	95/395 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 DDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQH--QLVSNSFQI-ESVRPKSSGSDDA 881
            ||....::..|::..|.|..........:.|..|:|.||.  ...:||.|| .::..:.:|..|:
  Fly    14 DDKHRHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDS 78

  Fly   882 N--DDNKARRKPLTLALA---------------------QNHNNNQNGSQPTPSSATILNGTVAK 923
            :  ..:..:.:..||:|:                     |..:.:.........|..:..|...:
  Fly    79 STLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYR 143

  Fly   924 PSKV--------------------------YLYIQMQLCRKESLRDWLRDNRSETRAAHIGD--I 960
            ..::                          .||:||:||| |||..:|      .|...|.:  |
  Fly   144 AERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCR-ESLEQYL------LRCQRIPEERI 201

  Fly   961 FHQIVD---AVDYVHLKGLIHRDLKPSNIFFSQDGQ-IKIGDFGLVTDMADIPNLVAKCGDQSGL 1021
            :|.::|   .:..:|.:.|||.|:|..|:...:|.: .|:.|||||.|:           |::.
  Fly   202 WHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDV-----------DRAN- 254

  Fly  1022 PSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYP 1086
                .|....|...||:||.|.| |:....||:|||:...||..|....... .....||.|..|
  Fly   255 ----SHHATEGDSRYMAPEILQG-HFSKAADIFSLGIAMLELACYMDLPSNG-PLWHELRHGILP 313

  Fly  1087 KDF--AVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQLPHL--LSEGQSEQAELAERARR 1147
            ::|  .::...| .:::.|:...|.|||..:||.|.       |.|  |.:.:......:..:|.
  Fly   314 EEFINKISLELQ-SVIKSMMKPDPAQRPTAEQLLSH-------PKLQYLQKKRKSLMNFSMLSRS 370

  Fly  1148 LSRSR 1152
            ..|||
  Fly   371 FRRSR 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	81/352 (23%)
		S_TKc	<925..1118	CDD:214567	61/226 (27%)
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	66/281 (23%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	66/279 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940