DRSC/TRiP Functional Genomics Resources

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Protein Alignment PEK and Eif2ak3

DIOPT Version :9

Sequence 1:NP_649538.1 Gene:PEK / 40653 FlyBaseID:FBgn0037327 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_113787.1 Gene:Eif2ak3 / 29702 RGDID:70884 Length:1108 Species:Rattus norvegicus


Alignment Length:1269 Identity:409/1269 - (32%)
Similarity:597/1269 - (47%) Gaps:301/1269 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RRRSLSFLQIVTLTMAGLVAFDPAQVLAGHPTTDSE--LQTAGSP----RPPGL----------- 59
            |.|:|..|.::....||:.|...|:.|.. ||:|:.  |..|.:|    |.|.:           
  Rat     8 RPRALLLLFLLLGCAAGISAVARARSLLA-PTSDTAFGLGAAAAPTSAARVPAVATAEVTVEDAE 71

  Fly    60 --------------EHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSS 110
                          |...|.|.|...|.|:.|||||||::|||....||.:|.:..|.|.|:|||
  Rat    72 ALPAASGEQESRATESDDDVELRPRGRSLVIISTLDGRIAALDAENHGKKQWDLDVGSGSLVSSS 136

  Fly   111 IHRLELTNNGQFVRMIPSLSGGIYKFDGD--SIDPIPITAEHLLSSSAKFSDDLVISGGKETRSY 173
            :.:.|:..|..   :||||.|.::::|.|  |::.:|.|.|.||.||.||.||:|:.|||...:|
  Rat   137 LSKPEVFGNKM---IIPSLDGDLFQWDRDRESMEAVPFTVESLLESSYKFGDDVVLVGGKSLTTY 198

  Fly   174 GVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVI 238
            |:|..:|:|.|.||..||              |..| .|::|:.|                 |::
  Rat   199 GLSAYSGKLRYICSALGC--------------RRWD-SDEMEEEE-----------------DIL 231

  Fly   239 IVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSEC---------QLQPRDELELAVLDVD-- 292
            :::|..:|||||..|:|.|:||||||..||..:...|.         :|....|....:.||:  
  Rat   232 LLQRTQKTVRAVGPRSGSEKWNFSVGHFELRYIPDMETRAGFIESTFKLGGNKEDSKIISDVEEQ 296

  Fly   293 -----IKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSSAQWLWDQD- 351
                 |||.|.:..:.||||...: :.|:|:|..||.|||... |.::.||.||....:..::: 
  Rat   297 DVDTVIKVSVADWKVMAFSKKGGR-LEWEYQFCTPIASAWLVR-DGKVIPISLFDDTSYTANEEV 359

  Fly   352 -ENDTELPNAPQ--SPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQLTGDTSL--MPRIPWK 411
             |::.::..|.:  :..|:|||||..|||:|.|:|:.::...:.|..:.:.|::::  :|.|.||
  Rat   360 LEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRVSEKFPTRPKALESVNGESAIIPLPTIKWK 424

  Fly   412 P-ISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYT 475
            | |.:.|::.|:...|:.|..:..:          .|..|.::..|.|:|   ::...||:|.  
  Rat   425 PLIHSPSRTPVLVGSDEFDKCLSND----------KYSHEEYSNGALSIL---QYPYDNGYYL-- 474

  Fly   476 TGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAP------- 533
                                    |..........|:.|            :..:|:|       
  Rat   475 ------------------------PYYKRERNKRSTQIT------------VRFLDSPHYSKNIR 503

  Fly   534 VKVVILSLWFWWKEI-----VVIAFTSAVILNIFMGQ-RNQRVEREYLVIERHVPVQTAIEATEA 592
            .|..|| |..|||||     :.|..|:.::..:|..| ..||.|.|                |:.
  Rat   504 KKDPIL-LLHWWKEIFGTILLCIVATTFIVRRLFHPQPHRQRKESE----------------TQC 551

  Fly   593 STQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVF 657
            .|::....|              ...|.........|||  |.||:.:|||.:||:|||||||||
  Rat   552 QTESKYDSV--------------SADNSDNSWNDIKHSG--YVSRYLTDFEPIQCMGRGGFGVVF 600

  Fly   658 EAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRK 722
            |||||:|:..||||||.|||:|.:|::|:||.:.||..||..|||||::|.||||..||||.|..
  Rat   601 EAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEI 665

  Fly   723 LLAHELSTSIQIETPDDSTMPSL----TEQLKEKRQQQLLSWVSDAANSTACSHDFHLP---GES 780
            .|..| ||...:.:|.....||:    .:....|.|.:::      |.|...|..|.:.   |.:
  Rat   666 WLKDE-STDWPLSSPSPMDAPSVKIRQMDPFSTKEQIEVI------APSPERSRSFSVGISCGRT 723

  Fly   781 SLKNIREEYDYDEEEDSLIEF-------RSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRS 838
            |         ..|.:.|.:||       .|:|:.||...::...||.|. ||....||.|     
  Rat   724 S---------SSESQFSPLEFSGTDCGDNSDSEDAAHNLQDSCLTDCDM-EDGTVDGDDE----- 773

  Fly   839 SVSIDIHSASFDL---KNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPL------TL 894
                   ..||:|   :...|::.:..::|    |:..:.||.|:|:.....|...|      ..
  Rat   774 -------GHSFELCPSEASPYTRSREGTSS----SIVFEDSGCDNASSKEDPRMNRLHNGHHYVN 827

  Fly   895 ALAQ-NHNNNQNGSQ---------PTPSSATILNGTV--AKPS--KVYLYIQMQLCRKESLRDWL 945
            .|.: .|:::::.|:         ||..|......||  .:||  ||||||||||||||:|:||:
  Rat   828 KLTEFKHSSSRSSSEATLSTSPTRPTTLSLDFTRNTVDRLQPSSPKVYLYIQMQLCRKENLKDWM 892

  Fly   946 R-----DNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDM 1005
            .     ::|......|   ||.||.:||.::|.|||:|||||||||||:.|..:|:|||||||.|
  Rat   893 NRRCSMEDREHRVCLH---IFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAM 954

  Fly  1006 ADIPNLVAKCGDQ--------SGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFE 1062
                       ||        :.:|:.|.||.||||.|||||||:.|.:|.:||||:|||||.||
  Rat   955 -----------DQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFE 1008

  Fly  1063 LHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQL 1127
            |...|||:|||::||..:|:.::|..|...|||::.::|.|||..|.:||:...           
  Rat  1009 LLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPQEHMMVQDMLSPSPMERPEATD----------- 1062

  Fly  1128 PHLLSEGQSEQAELAERARRLSRSRTFSSSSEPH 1161
              ::.....|..|...:.....|||:.|||...|
  Rat  1063 --IIENAVFENLEFPGKTVLRQRSRSLSSSGTKH 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PEKNP_649538.1 Luminal_EIF2AK3 73..401 CDD:188874 119/349 (34%)
PKc_like 635..1113 CDD:304357 209/527 (40%)
S_TKc <925..1118 CDD:214567 103/207 (50%)
Eif2ak3NP_113787.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1080..1108 7/15 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..92 2/20 (10%)
Luminal_EIF2AK3 99..412 CDD:188874 119/349 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..563 7/50 (14%)
PKc_like 579..>667 CDD:304357 55/87 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 772..818 12/61 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 832..856 4/23 (17%)
STKc_EIF2AK3_PERK <868..1067 CDD:270950 104/225 (46%)
S_TKc <873..1065 CDD:214567 102/218 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 196 1.000 Domainoid score I3042
eggNOG 1 0.900 - - E1_KOG1033
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 484 1.000 Inparanoid score I1393
OMA 1 1.010 - - QHG49379
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 1 1.000 - - FOG0005413
OrthoInspector 1 1.000 - - oto98860
orthoMCL 1 0.900 - - OOG6_106778
Panther 1 1.100 - - O PTHR11042
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3837
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.840

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