Protein Alignment PEK and EIF2AK1

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_055228.2
• Gene: EIF2AK1 / 27102
• HGNCID: 24921
• Length: 630
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 171/552 - (30%)
• Similarity: 254/552 - (46%)
• Gaps: 121/552 - (21%)

  Fly   632 EHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR---QRVLREARTLA 693
            |..|||:.::||.:..||:||:|.|::.:||||...||||:|.:  |.:::   .:||||.:.||
Human   157 EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILI--KGATKTVCMKVLREVKVLA 219

  Fly   694 SCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLL 758
            ..:|.|||.|..:|.|.... .|...||          ..||.|   ::..|::| :|.|:|
Human   220 GLQHPNIVGYHTAWIEHVHV-IQPRADR----------AAIELP---SLEVLSDQ-EEDREQ--- 266

  Fly   759 SWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDY- 822
                       |          .:||       ||...|.|.|          ||...:.:..:
Human   267 -----------C----------GVKN-------DESSSSSIIF----------AEPTPEKEKRFG 293

  Fly   823 EEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIES-VRPKSSGSDDANDDNK 886
            |.|.|.|.:                    |::.|:.:.::..|.::|| :..:.:|....:..:.
Human   294 ESDTENQNN--------------------KSVKYTTNLVIRESGELESTLELQENGLAGLSASSI 338

  Fly   887 ARRKPLTLALAQNHNNNQNGSQPTPSSATILN--GTVAKPSKVYLYIQMQLCRKESLRDWL---- 945
            ..::   |.|.:|.:..::.:....||...:|  |.......:.|:|||||| :.||.||:
Human   339 VEQQ---LPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLC-ELSLWDWIVERN 399

  Fly   946 ---RDNRSETRAAHI-----GDIFHQIVDAVDYVHLKGLIHRDLKPSNIFF-SQDGQIKIGDFGL 1001
               |:...|:...::     ..||.::|:.|.|:|..|::||||||.|||. ..|.|:|||||||
Human   400 KRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGL 464

  Fly  1002 V-TDM----ADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFF 1061
            . ||:    .|..|...|        ....||.:|||.||.|||||.|..||.|.|:||||::..
Human   465 ACTDILQKNTDWTNRNGK--------RTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLL 521

  Fly  1062 ELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQL---- 1121
            ||...|.|||||.:.|..||.||.|:......|.|...:|.:......|||...| |:|:|
Human   522 ELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNS 586

  Fly  1122 RNI-LQLPHLLSEGQSEQAELAERARRLSRSR 1152
            .|: |.|...:.|.:.|.|||.::...||:.:
Human   587 GNVNLTLQMKIIEQEKEIAELKKQLNLLSQDK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	155/502 (31%)
		S_TKc	<925..1118	CDD:214567	85/211 (40%)
EIF2AK1	NP_055228.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_EIF2AK1_HRI	160..581	CDD:270951	158/510 (31%)
		S_TKc	167..583	CDD:214567	156/505 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..301		17/83 (20%)
		HRM 1	410..415		0/4 (0%)
		HRM 2	552..557		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920