Protein Alignment PEK and Eif2ak2

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_006523926.1
• Gene: Eif2ak2 / 19106
• MGIID: 1353449
• Length: 529
• Species: Mus musculus
• Alignment Length: 550
• Identity: 140/550 - (25%)
• Similarity: 197/550 - (35%)
• Gaps: 243/550 - (44%)

  Fly   592 ASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSG----------EHYT--SRFQSDFEL 644
            :|:.::....|....||   ||.........:.|:...||          ..||  :||.||||.
Mouse   197 SSSSSMTSNGVSQSAPG---SFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFED 258

  Fly   645 MQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTE 709
            ::.:|.||||.||:||:::|..||||||:     :.:.::...|.:.||...|.|||:|...|
Mouse   259 IEEIGLGGFGQVFKAKHRIDGKRYAIKRV-----KYNTEKAEHEVQALAELNHVNIVQYHSCW-- 316

  Fly   710 TPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDF 774
                                                                             
Mouse   317 ----------------------------------------------------------------- 316

  Fly   775 HLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSS 839
                        |..|||.|
Mouse   317 ------------EGVDYDPE--------------------------------------------- 324

  Fly   840 VSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQ 904
                 ||.|                                  |.::.:.:
Mouse   325 -----HSMS----------------------------------DTSRYKTR-------------- 336

  Fly   905 NGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLRD-NRSETRAAHIGDIFHQIVDAV 968
                                   .|:|||:.|.|.:|..|:|: |:|:...|.|.|::.|||..|
Mouse   337 -----------------------CLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGV 378

  Fly   969 DYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGT 1033
            :|:|.||||||||||.|||...:..||||||||.|.:           :..|    ...|::.||
Mouse   379 EYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATAL-----------ENDG----KSRTRRTGT 428

  Fly  1034 HLYMSPEQLLGQHYDYKVDIYSLGLIFFE-LHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQY 1097
            ..|||||||..:||..:|||::||||..| ||..| ||.|:||...|||.|.:..|...|  ::.
Mouse   429 LQYMSPEQLFLKHYGKEVDIFALGLILAELLHTCF-TESEKIKFFESLRKGDFSNDIFDN--KEK 490

  Fly  1098 DLLQQMLSAQPEQRPQTKQLKSQL---RNI 1124
            .||:::||.:|:.||:|.::...|   |||
Mouse   491 SLLKKLLSEKPKDRPETSEILKTLAEWRNI 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	124/481 (26%)
		S_TKc	<925..1118	CDD:214567	85/194 (44%)
Eif2ak2	XP_006523926.1	DSRM_EIF2AK2_rpt1	21..88	CDD:380732
		DSRM_EIF2AK2_rpt2	108..175	CDD:380733
		PKc_like	249..514	CDD:389743	125/487 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4549
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950