Protein Alignment PEK and gcn-2

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001367229.1
• Gene: gcn-2 / 174953
• WormBaseID: WBGene00013591
• Length: 1699
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 151/555 - (27%)
• Similarity: 240/555 - (43%)
• Gaps: 121/555 - (21%)

  Fly   637 RFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSR--QRVLREARTLASCEHHN 699
            |..:|..:::.|||||||.|...:||:|...||||||.| |.:|.:  :::.:||:..|...|.|
 Worm   486 RMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPL-NAKSDKLNRKIAKEAKFFAKLNHPN 549

  Fly   700 IVRYFHSWTE--TPPTGWQEEEDRKLLA------------HELSTSIQIETPD--------DSTM 742
            :|||:::|.|  .|......::|..|.|            .:|.|...:|..:        ||.|
 Worm   550 MVRYYYAWAEDLIPIVEETSDDDSSLGAVPIPGKEKIGKKGKLKTGKSLEDKENKANLGGGDSLM 614

  Fly   743 P----------SLTEQLKE-------KRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYD 790
            |          |:....||       ....:..|.:..:..||.         ...||::.|...
 Worm   615 PMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTP---------SGGLKHLSECSS 670

  Fly   791 YDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNIN 855
            .||::|...|...:::|..:..||.||:|::.|:|.|:                      |..:|
 Worm   671 DDEDDDDSSEIDWDAESEEVEDEESDDSDEEDEDDGER----------------------LVQLN 713

  Fly   856 YSQHQLVSNSFQIESVRPKSSGSDD------ANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSA 914
                  ...|...:||..:|:..:|      :.|.|..||:.:.|.       ..|.:..:.|..
 Worm   714 ------TETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELM-------EINTTTTSKSKL 765

  Fly   915 TILNGTVAKPSKVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHR 979
            .|....|.||.  .|.|||:.|.:.:||.::.:|........:..||.:::..:.|:|...:|||
 Worm   766 AIDVVPVRKPR--ILCIQMEYCDRATLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHR 828

  Fly   980 DLKPSNIFFSQDGQIKIGDFGLVT--DMADIPNLVAKCGDQS----------GLP---SCARHTQ 1029
            |:||.|||.:....:|||||||.|  .|:....:|....::|          |:.   |....|:
 Worm   829 DIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTR 893

  Fly  1030 QVGTHLYMSPEQLLGQ--H---YDYKVDIYSLGLIFFEL-HVYFSTEMERIKTLRSLRDG-QYPK 1087
            .:||.|||:||..:.:  |   |..|:||||.|::.||: :......|:|:.||.:|||. :.|.
 Worm   894 DIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLRDDIKIPS 958

  Fly  1088 DFAVNYPQQY-----DLLQQMLSAQPEQRPQTKQL 1117
            ||........     ..:::||...|::||....|
 Worm   959 DFGAGLAAPMAGLARRTVEKMLQRNPDERPTADDL 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	149/549 (27%)
		S_TKc	<925..1118	CDD:214567	68/220 (31%)
gcn-2	NP_001367229.1	RWD	23..138	CDD:214735
		PKc_like	217..>373	CDD:419665
		PKc_like	486..>560	CDD:419665	31/74 (42%)
		PKc_like	<776..997	CDD:419665	68/220 (31%)
		class_II_aaRS-like_core	1106..>1227	CDD:412273
		HisZ	<1141..1397	CDD:226228

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920