Protein Alignment PEK and Eif2ak1

DIOPT Version :9

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_038585.2
• Gene: Eif2ak1 / 15467
• MGIID: 1353448
• Length: 619
• Species: Mus musculus
• Alignment Length: 557
• Identity: 166/557 - (29%)
• Similarity: 249/557 - (44%)
• Gaps: 134/557 - (24%)

  Fly   632 EHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPN-KESSRQRVLREARTLASC 695
            |..|||:.::||.:..||:||:|.|::.:||||...||||:|.:.: .::...:||||.:.||..
Mouse   157 EAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGL 221

  Fly   696 EHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDST---MPSLTEQLKEKRQQQL 757
            :|.|||.|..:|.|                     .:.:..|.|..   :||| |.|.|:...:.
Mouse   222 QHPNIVGYHTAWIE---------------------HVHVVQPQDRVPIQLPSL-EVLSEQEGDRD 264

  Fly   758 LSWVSDAANSTACSHDFHLP------GESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEED 816
            ...|.|..:|::.......|      |||.:||         |.::|:.:   :.:..:|...|.
Mouse   265 QGGVKDNESSSSIVFAELTPEKEKPFGESEVKN---------ENNNLVSY---TANLVVRNSSES 317

  Fly   817 DTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQL-VSNSFQIESVRPKSSGSDD 880
            ::..:.:||                     ...||......:||| :.:|.::|.   ..:.:|:
Mouse   318 ESSIELQED---------------------GLTDLSVRPVVRHQLPLGHSSELEG---NFTSTDE 358

  Fly   881 ANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILN--GTVAKPSKVYLYIQMQLCRKESLRD 943
            :::.|                               ||  |.......:.|:|||||| :.||.|
Mouse   359 SSEGN-------------------------------LNLLGQTEVRYHLMLHIQMQLC-ELSLWD 391

  Fly   944 WLRDNRSETR------------AAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFF-SQDGQIK 995
            |:.:....:|            |:....||.::|:.|.|:|..|::||||||.|||. ..|.|:|
Mouse   392 WITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVK 456

  Fly   996 IGDFGL----VTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSL 1056
            ||||||    :...||..|...| |.::       ||.:|||.||.|||||.|..||.|.|:|||
Mouse   457 IGDFGLACADIIQNADWTNRNGK-GTRT-------HTSRVGTCLYASPEQLEGSQYDAKSDMYSL 513

  Fly  1057 GLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ-LKSQ 1120
            |:|..||...|.|||||...|..:|.|:.|:..:...|.|...:|.:......|||...| |:|:
Mouse   514 GVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQSE 578

  Fly  1121 L----RNI-LQLPHLLSEGQSEQAELAERARRLSRSR 1152
            |    .|: |.|...:.|.:.|..||.::...||:.|
Mouse   579 LFQTTGNVNLTLQMKIIEQEKEIEELKKQLSLLSQDR 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		PKc_like	635..1113	CDD:304357	150/507 (30%)
		S_TKc	<925..1118	CDD:214567	84/210 (40%)
Eif2ak1	NP_038585.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_EIF2AK1_HRI	160..578	CDD:270951	153/515 (30%)
		Pkinase	167..580	CDD:278497	151/510 (30%)
		HRM 1	408..413		0/4 (0%)
		HRM 2	549..554		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920