Protein Alignment PEK and Gcn2

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_061511700.1
• Gene: Gcn2 / 1280343
• VectorBaseID: AGAMI1_005912
• Length: 1661
• Species: Anopheles gambiae
• Alignment Length: 1215
• Identity: 272/1215 - (22%)
• Similarity: 443/1215 - (36%)
• Gaps: 456/1215 - (37%)

  Fly   199 LAIDDTIREPDEEDQLEDGEQLRDEAGYIVR---HDPLLDDVIIVRRQTQTVRAVESRTGVERWN 260
            :|..:|||| .:|::||           :::   ||.:.|              :..|||  :|
Mosquito     1 MAKKETIRE-RQENELE-----------VIKSIFHDEVED--------------LRPRTG--KW- 36

  Fly   261 FSVGQHELDLVRPSECQLQ---PRDELELAVLDVDIKVVVPEGIICA--FSKSEPQTMLWKYKFD 320
                       :|.|.:|.   .|...:.|.:..|:.|.      |:  :.|..|     |.:..
Mosquito    37 -----------KPLELRLHLTPQRGSAKEAYVKADLYVT------CSPKYPKCPP-----KLELK 79

  Fly   321 HPIVSAWNTNADDELQPIDLFSSAQWLWDQDENDT---ELPNAPQS-------PP--SIY---LG 370
            |.:      ...|.|.. :|....:.|.|:.:.:.   ||.|..|:       ||  |.|   |.
Mosquito    80 HAV------GLSDSLVR-ELTEKLEQLADELKGEVMIFELANTVQAFLHQHNVPPKGSFYDEMLA 137

  Fly   371 MYDKQLY----------------IQESIRLRQEIMDQT-KVYQQLTGDTSLMPRIPWKPISASS- 417
            ...||..                ||:.::.|::.:::| :..:..|.::|.|.|:.    |:||
Mosquito   138 NQQKQALARQNTLQAEETLKRQAIQDELQRRKKELERTRRESRHSTNESSPMHRLH----SSSST 198

  Fly   418 ------------KSLVIF----RK--------------------DQEDPEMI------------- 433
                        :|.|::    ||                    ||:..|::
Mosquito   199 ENSDGAYCVEHRRSEVLYFRDGRKVLRGSCLGHSQRGCIAYAGIDQQTGELVYLTEWTLYYDGEC 263

  Fly   434 -AEGAVAQG-------GE---------------LVPYDD-------------------------- 449
             ||....:|       ||               |:.|:.
Mosquito   264 SAESRTIRGRPVETVVGEMERLADGLIPLKHKHLIAYEGVLCRMGKEALTLFVVQEFILGTSLFS 328

  Fly   450 ---------ENFAVAAQSVLNASEFVNGNGFYFYTTGD------------------------LNG 481
                     |..::.|:..|.|..:::.||.......|                        |:.
Mosquito   329 ISGSLGWSVEGASMVAKGTLEALIYLHNNGVSHDNLSDSTVFMDNAGMVRVADFRLIPYIQELSD 393

  Fly   482 PQECSTQN-NPTDLP-------AITAPTS---------PTNATSEGTEATGNHSVNDDLGFSLDD 529
            .|....|: ...|||       |:.||.|         .:..|...||...:..:...|....|.
Mosquito   394 SQHLLHQSLRSPDLPSLGGLIEALLAPHSEMKDFVERCKSERTISATELLDHPFLRSTLLLHTDH 458

  Fly   530 IDAPVKVVILSLWFWWKEIVVIAFTSAVILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEAST 594
            :.           ...:::...|...|:.....:|||::..:::.|
Mosquito   459 VA-----------MGQQQLTAAALQKALPAPTTVGQRSENGQQQQL------------------- 493

  Fly   595 QALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEA 659
            |..|.|.:|:...|:      |...::              ||.|::|||:..||:|.:|.|.:.
Mosquito   494 QQQLVPYMPLVMNGS------GTGQEK--------------SRIQTEFELLSYLGKGAYGDVLKV 538

  Fly   660 KNKLDENRYAIKRITLPNKESSRQ---RVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDR 721
            :||||...||||||.||.:  |:|   ::.||...|:...|.|:|||::||.|...|.
Mosquito   539 RNKLDNREYAIKRIRLPAR--SKQFYKKMTREVELLSRLNHENVVRYYNSWVEATSTA------- 594

  Fly   722 KLLAHELSTSIQIETPDDSTMPSLTEQL--KEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKN 784
            ::||   :|..:.|.....|:.|....:  :.||:...:.    ...:||.:.|....|... ||
Mosquito   595 EMLA---ATDTEGEMAGGGTVSSCDWSVASRPKRRASRVR----RTTATAAAADLVKKGIED-KN 651

  Fly   785 IREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASF 849
            |          |..::|.....|:   .|:||:.|||...|.::              |..|:|.
Mosquito   652 I----------DCFVDFLPNDTSS---EEDEDEEDDDETNDLDE--------------DSSSSSS 689

  Fly   850 DLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSS- 913
            |..:.:.|.|:.::.    ||....|.|.:..                     ..||..|:.:|
Mosquito   690 DESSGSISNHRKLNE----ESFNDSSGGIEFV---------------------GSNGEAPSYNSY 729

  Fly   914 ----ATILNG-------TVAKPSKVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDA 967
                :.:.||       |.|.|..:|:||||:.|.|.:||..: |.........:..:|.:||:.
Mosquito   730 GEAGSAVENGGGKKAATTPAPPEVLYMYIQMEFCEKSTLRTAI-DAGLYQDIDRVWRLFREIVEG 793

  Fly   968 VDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVA--KCGDQSGLPSCARH--- 1027
            :.::|.:|:|||||||.|||.....|:|||||||.|     .:::|  ..|.|:..|....|
Mosquito   794 LSHIHQQGMIHRDLKPVNIFLDSRDQVKIGDFGLAT-----TSILALQNQGHQNATPGQMGHLAV 853

  Fly  1028 ---------------TQQVGTHLYMSPEQLLG----QHYDYKVDIYSLGLIFFELHVY-FSTEME 1072
                           |.:|||.||::|| |.|    ..|:.|||:||||:|.||:... .:|.||
Mosquito   854 ASIQQGKSSDIGYSLTGKVGTALYVAPE-LTGNASRSTYNQKVDLYSLGIILFEMSSQPLNTGME 917

  Fly  1073 RIKTLRSLRDGQYPKDFAVNYPQ------QYDLLQQ----MLSAQPEQR------------PQTK 1115
            |:|||..||..      |:..|:      :|..|.|    :|:..|::|            |:|:
Mosquito   918 RVKTLMDLRSD------AIRLPEALLTDARYSRLVQVIRWLLNHDPQKRPTAEEVLCSELVPRTR 976

  Fly  1116 QLKSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSSEP 1160
            ....:::::::  |:||..||       |..:...:|.|:.:|:|
Mosquito   977 LEAEEIQDVVR--HILSNPQS-------RHYKHLIARCFAQASDP 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	48/241 (20%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	158/541 (29%)
Gcn2	XP_061511700.1	None