Protein Alignment PEK and eif2ak4

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_012823581.1
• Gene: eif2ak4 / 100216307
• XenbaseID: XB-GENE-967321
• Length: 1674
• Species: Xenopus tropicalis
• Alignment Length: 858
• Identity: 201/858 - (23%)
• Similarity: 335/858 - (39%)
• Gaps: 288/858 - (33%)

  Fly   425 KDQEDPEMIAEGAVAQ---GGELVPYDDENFAV--------AAQSVLNASEFVNGNGFYFYTTGD 478
            |::||  .|:.|.:|:   |.:|..|.::...|        .|| :|:|.::::.|.......
 Frog   384 KEKED--SISVGIIAEHVNGTKLSSYLEQGVPVPLDQLRHYTAQ-LLSALDYLHSNSVVHKVM-- 443

  Fly   479 LNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDDLG--------------FSLD- 528
                  |:               |....|::|.....::|::..|.              ||.|
 Frog   444 ------CA---------------SSVLVTADGKVKLTDYSLSKRLADICKEDVFEQTKVRFSEDA 487

  Fly   529 ---------DIDAPVKVVILSLWFWWKEIVVIAFTSAVILNIFMGQRNQRVEREYLV-IERHVPV 583
                     ||              ||       ...::|::..|    .:.:||.| :...:|.
 Frog   488 LPSKSGKKGDI--------------WK-------LGLLLLSLSQG----NIAKEYPVKVPSDLPA 527

  Fly   584 Q--------TAIEATEA-STQALLGPVVPMQRPGNRFSFPPGQAN-------------------- 619
            .        ..:|..|. :||.||         .:.|..||.:.:
 Frog   528 DFQDFLQKCVCLEDKERWTTQQLL---------SHSFLNPPPEKSPVTEECSDDYPGDCTETVIP 583

  Fly   620 QRTISESTTH-SGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQ 683
            :.::|.||.| ..:...||:.::||.:|.||:|.||.|.:.:||||...||:||:.:.......:
 Frog   584 RSSVSNSTFHIESQRQFSRYFNEFEELQMLGKGAFGAVIKVQNKLDGCYYAVKRVQINPASKQFR 648

  Fly   684 RVLREARTLASCEHHNIVRYFHSWTE-------TPPTGWQEE-----EDRKLLAHELSTSIQIET 736
            |:..|...|:...|.|||||:::|.|       :|.....||     :..:::.::|.....||
 Frog   649 RIKGEVTLLSRLNHENIVRYYNAWIEKHEHPTISPKCEAHEEKKVTVKPEQIVKNDLGLLDDIE- 712

  Fly   737 PDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEF 801
             :::..|.||..::         |      ||:|
 Frog   713 -ENAPAPILTSSVE---------W------STSC------------------------------- 730

  Fly   802 RSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSF 866
             ..|.||.....::|.:|||.::|||               .:.|.|| |...:.....:..|
 Frog   731 -ERSSSAHCTNGDQDSSDDDDDDDEE---------------GVFSPSF-LPGTDSDSEIIFEN-- 776

  Fly   867 QIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYI 931
                       .||.:.|             |:...::|..:...:.|    ..:...:..||||
 Frog   777 -----------EDDISPD-------------QDEEYDKNNVEDRKAGA----NEIVTQAVHYLYI 813

  Fly   932 QMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKI 996
            ||:.|.|.:|||.: |.........:..:|.:|:|.:.|:|.:|:|||||||.|||...:..:||
 Frog   814 QMEYCEKSTLRDTI-DQGLYMDVGRLWRLFREILDGLTYIHEQGMIHRDLKPVNIFLDSEDHVKI 877

  Fly   997 GDFGLVTD----------------MADIPNLVAKCGDQSGLPSCARHTQ-----QVGTHLYMSPE 1040
            |||||.||                .:|:..:..:  |::..|  .|:||     .|||.||:|||
 Frog   878 GDFGLATDHPASYTESAQGEEDQAHSDLVKVDPE--DRASTP--GRNTQGKLTGMVGTALYVSPE 938

  Fly  1041 QLLGQ---HYDYKVDIYSLGLIFFEL-HVYFSTEMERIKTLRSLRDG--QYPKDFAVNYPQ---Q 1096
             :.|.   .|:.|||:||||:|.||: :....|..|||..|..||..  .:|.||  ..|:   |
 Frog   939 -VQGNTKASYNQKVDLYSLGIILFEMSYRPMDTSSERISVLSRLRQALIVFPSDF--ENPENEKQ 1000

  Fly  1097 YDLLQQMLSAQPEQRPQTKQL------------KSQLRNILQLPHLLS--EGQSEQAELAE-RAR 1146
            ..::..:|:..|..||...:|            :|:|..:|.  |.|:  :|::.:..::: .|:
 Frog  1001 KKVITWLLNHDPASRPTAMELLKCDLLPPPQLEESELHEVLH--HTLANIDGKAYRTMMSQIFAQ 1063

  Fly  1147 RLSRSRTFSSSSE 1159
            |:|.:..::..|:
 Frog  1064 RISPAMDYTYDSD 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874
		Protein Kinases, catalytic domain	635..1113	CDD:473864	142/519 (27%)
eif2ak4	XP_012823581.1	RWD_GCN2	34..149	CDD:467659
		PK_eIF2AK_GCN2_rpt1	316..555	CDD:270914	40/230 (17%)
		STKc_EIF2AK4_GCN2_rpt2	600..1025	CDD:270948	144/527 (27%)
		PLN02972	<1100..1518	CDD:215525